Inverse association of non-steroidal anti-inflammatory drugs and malignant melanoma among women

  • Authors:
    • Randall E. Harris
    • Joanne Beebe-Donk
    • Kadambari K. Namboodiri
  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/or.8.3.655
  • Pages:655-657
0

Abstract

Recent human epidemiologic studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) have preventive effects against cancers of the colon, breast, and prostate. Laboratory and animal studies also provide evidence of antineoplastic effects of NSAIDs against a variety of solid tumors, including skin cancer. We studied the effects of NSAIDs on malignant melanoma in women utilizing a case control experimental design involving 110 women with histologically proven malignant melanoma, and 609 female controls frequency matched to the cases on age, and place of residence. We observed a significant decrease in the relative risk (RR) of malignant melanoma with regular intake of common over the counter NSAIDs such as aspirin and ibuprofen (RR=0.45, 95% CI=0.22-0.92, p<0.05). Adjustment for sun exposure did not change the magnitude of the estimate. Our results are the first to show that NSAIDs may have value in the chemoprevention of malignant melanoma.

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May 2001
Volume 8 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
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APA
Harris, R.E., Beebe-Donk, J., & Namboodiri, K.K. (2001). Inverse association of non-steroidal anti-inflammatory drugs and malignant melanoma among women. Oncology Reports, 8, 655-657. https://doi.org/10.3892/or.8.3.655
MLA
Harris, R. E., Beebe-Donk, J., Namboodiri, K. K."Inverse association of non-steroidal anti-inflammatory drugs and malignant melanoma among women". Oncology Reports 8.3 (2001): 655-657.
Chicago
Harris, R. E., Beebe-Donk, J., Namboodiri, K. K."Inverse association of non-steroidal anti-inflammatory drugs and malignant melanoma among women". Oncology Reports 8, no. 3 (2001): 655-657. https://doi.org/10.3892/or.8.3.655