Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas

  • Authors:
    • Vorasuk Shotelersuk
    • Chupong Ittiwut
    • K. Shotelersuk
    • S. Triratanachat
    • Yong Poovorawan
    • Apiwat Mutirangura
  • View Affiliations

  • Published online on: November 1, 2001     https://doi.org/10.3892/or.8.6.1301
  • Pages: 1301-1304
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

An S249C mutation in fibroblast growth factor receptor 3 (FGFR3) gene was recently identified in patients with cervical carcinomas (CC). However, its importance in cervical tumorigenesis is still inconclusive. Apart from CC, nasopharyngeal carcinoma (NPC) is the other major virus associated squamous cell carcinoma. We sought to clarify the frequency of the FGFR3 S249C mutation in 75 primary CC in the Thai population and to determine its prevalence in 69 primary NPC by PCR and restriction enzyme digestion. None of the patients but one NPC showed the enzyme digestion pattern consistent with the mutation. This is the first report demonstrating the role of FGFR3 in the development of human NPC. This study confirms the low frequency of the FGFR3 S249C mutation in CC. Nevertheless, the discovery of the mutation, not only in CC as reported by previous studies, but in NPC based on this report, suggests that FGFR3 may play a significant role in human CC and NPC development.

Related Articles

Journal Cover

October 2001
Volume 8 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Shotelersuk, V., Ittiwut, C., Shotelersuk, K., Triratanachat, S., Poovorawan, Y., & Mutirangura, A. (2001). Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas. Oncology Reports, 8, 1301-1304. https://doi.org/10.3892/or.8.6.1301
MLA
Shotelersuk, V., Ittiwut, C., Shotelersuk, K., Triratanachat, S., Poovorawan, Y., Mutirangura, A."Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas". Oncology Reports 8.6 (2001): 1301-1304.
Chicago
Shotelersuk, V., Ittiwut, C., Shotelersuk, K., Triratanachat, S., Poovorawan, Y., Mutirangura, A."Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas". Oncology Reports 8, no. 6 (2001): 1301-1304. https://doi.org/10.3892/or.8.6.1301