Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
January-February 2013 Volume 1 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-February 2013 Volume 1 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Oral verrucous carcinoma arising from lichen planus and esophageal squamous cell carcinoma in a patient with hepatitis C virus-related liver cirrhosis-hyperinsulinemia and malignant transformation: A case report

  • Authors:
    • Yumiko Nagao
    • Michio Sata
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan
  • Pages: 53-56
    |
    Published online on: October 3, 2012
       https://doi.org/10.3892/br.2012.14
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oral lichen planus (OLP) is a potentially malignant disorder associated with an increased risk of oral cancer. In Japan, the association of OLP with hepatitis C virus (HCV) infection is well documented. In the present study, a case of oral verrucous carcinoma arising from OLP coexisting vulvo‑vaginal‑gingival syndrome and esophageal squamous cell carcinoma (SCC) in a patient with HCV‑related liver cirrhosis is reported. A 71‑year old, non‑smoking Japanese woman presented with lesions of OLP affecting the bilateral buccal mucosa, tongue, gingival, palate, oral floor and lower lip. Ten years later, an exophytic mass developed in the mandibular alveolar mucosa, the right buccal mucosa and the right lower lip. Pathological diagnosis confirmed the presence of verrucous carcinoma. However, she developed esophageal rather than oral cancer. The oral cancer was resected surgically three times and the patients underwent radiotherapy. The esophageal cancer was removed by endoscopic submucosal dissection. The risk of carcinogenesis increased as hyperinsulinemia continued. The results suggested that it is necessary to monitor for malignant changes in patients with OLP lesions and HCV infection. In addition, treatment requires the cooperation of various medical specialists, as well as an oral surgeon.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1. 

Eisen D: The evaluation of cutaneous, genital, scalp, nail, esophageal, and ocular involvement in patients with oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 88:431–436. 1999. View Article : Google Scholar : PubMed/NCBI

2. 

Le Cleach L and Chosidow O: Clinical practice. Lichen planus. N Engl J Med. 366:723–732. 2012.

3. 

Pelisse M, Leibowitch M, Sedel D and Hewitt J: A new vulvovaginogingival syndrome. Plurimucous erosive lichen planus. Ann Dermatol Venereol. 109:797–798. 1982.(In French).

4. 

Warnakulasuriya S, Johnson NW and van der Waal I: Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 36:575–580. 2007. View Article : Google Scholar : PubMed/NCBI

5. 

Gandolfo S, Richiardi L, Carrozzo M, et al: Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population. Oral Oncol. 40:77–83. 2004. View Article : Google Scholar : PubMed/NCBI

6. 

Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB and Thongprasom K: Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 100:164–178. 2005. View Article : Google Scholar : PubMed/NCBI

7. 

Gonzalez-Moles MA, Scully C and Gil-Montoya JA: Oral lichen planus: controversies surrounding malignant transformation. Oral Dis. 14:229–243. 2008. View Article : Google Scholar

8. 

Bermejo-Fenoll A, Sánchez-Siles M, López-Jornet P, Camacho-Alonso F and Salazar-Sánchez N: A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. J Oral Pathol Med. 39:491–496. 2010. View Article : Google Scholar : PubMed/NCBI

9. 

Warnakulasuriya S, Kovacevic T, Madden P, Coupland VH, Sperandio M, Odell E and Møller H: Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10-year period in South East England. J Oral Pathol Med. 40:677–683. 2011.

10. 

Bombeccari GP, Guzzi G, Tettamanti M, Giannì AB, Baj A, Pallotti F and Spadari F: Oral lichen planus and malignant transformation: a longitudinal cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 112:328–334. 2011. View Article : Google Scholar : PubMed/NCBI

11. 

Nagao Y, Sata M, Tanikawa K, Itoh K and Kameyama T: Lichen planus and hepatitis C virus in the northern Kyushu region of Japan. Eur J Clin Invest. 25:910–914. 1995. View Article : Google Scholar : PubMed/NCBI

12. 

Lodi G, Giuliani M, Majorana A, Sardella A, Bez C, Demarosi F and Carrassi A: Lichen planus and hepatitis C virus: a multicentre study of patients with oral lesions and a systematic review. Br J Dermatol. 151:1172–1181. 2004. View Article : Google Scholar : PubMed/NCBI

13. 

Shengyuan L, Songpo Y, Wen W, Wenjing T, Haitao Z and Binyou W: Hepatitis C virus and lichen planus: a reciprocal association determined by a meta-analysis. Arch Dermatol. 145:1040–1047. 2009.PubMed/NCBI

14. 

Lodi G, Pellicano R and Carrozzo M: Hepatitis C virus infection and lichen planus: a systematic review with meta-analysis. Oral Dis. 16:601–612. 2010. View Article : Google Scholar : PubMed/NCBI

15. 

Petti S, Rabiei M, De Luca M and Scully C: The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study. Odontology. 99:168–178. 2011. View Article : Google Scholar : PubMed/NCBI

16. 

Nagao Y, Sata M, Tanikawa K, Itoh K and Kameyama T: High prevalence of hepatitis C virus antibody and RNA in patients with oral cancer. J Oral Pathol Med. 24:354–360. 1995. View Article : Google Scholar : PubMed/NCBI

17. 

Nagao Y, Sata M, Itoh K, et al: High prevalence of hepatitis C virus antibody and RNA in patients with head and neck squamous cell carcinoma. Hepatol Res. 7:206–212. 1997.

18. 

Nobles J, Wold C, Fazekas-May M, Gilbert J and Friedlander PL: Prevalence and epidemiology of hepatitis C virus in patients with squamous cell carcinoma of the head and neck. Laryngoscope. 114:2119–2122. 2004. View Article : Google Scholar : PubMed/NCBI

19. 

Hunt J, Hagan J, Nobles J, Wold C, Fazekas-May M, Gilbert J and Friedlander PL: Outcome analysis of patients with squamous cell carcinoma of the head and neck and hepatitis C virus. Laryngoscope. 115:1882–1886. 2005. View Article : Google Scholar : PubMed/NCBI

20. 

Yoshida M, Nagao Y, Sata M, Kusukawa J and Kameyama T: Multiple primary neoplasms and hepatitis C virus infection in oral cancer patients. Hepatol Res. 9:75–81. 1997. View Article : Google Scholar

21. 

Nagao Y and Sata M: High incidence of multiple primary carcinomas in HCV-infected patients with oral squamous cell carcinoma. Med Sci Monit. 15:CR453–CR459. 2009.PubMed/NCBI

22. 

Carrozzo M, Carbone M, Gandolfo S, Valente G, Colombatto P and Ghisetti V: An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. Oral Oncol. 33:220–225. 1997. View Article : Google Scholar : PubMed/NCBI

23. 

Spiro RH: Verrucous carcinoma, then and now. Am J Surg. 176:393–397. 1998. View Article : Google Scholar : PubMed/NCBI

24. 

Sikuler E, Shnaider A, Zilberman D, Hilzenrat N, Shemer-Avni Y, Neumann L and Buskila D: Hepatitis C virus infection and extrahepatic malignancies. J Clin Gastroenterol. 24:87–89. 1997. View Article : Google Scholar : PubMed/NCBI

25. 

Lee MH, Yang HI, Lu SN, et al: Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study. J Infect Dis. 206:469–477. 2012. View Article : Google Scholar : PubMed/NCBI

26. 

Nagao Y, Kawaguchi T, Tanaka K, Kumashiro R and Sata M: Extrahepatic manifestations and insulin resistance in an HCV hyperendemic area. Int J Mol Med. 16:291–296. 2005.PubMed/NCBI

27. 

Nagao Y, Kawasaki K and Sata M: Insulin resistance and lichen planus in patients with HCV-infectious liver diseases. J Gastroenterol Hepatol. 23:580–585. 2008. View Article : Google Scholar : PubMed/NCBI

28. 

Jee SH, Ohrr H, Sull JW, Yun JE, Ji M and Samet JM: Fasting serum glucose level and cancer risk in Korean men and women. JAMA. 293:194–202. 2005. View Article : Google Scholar

29. 

Kawaguchi T and Sata M: Importance of hepatitis C virus-associated insulin resistance: therapeutic strategies for insulin sensitization. World J Gastroenterol. 28:1943–1952. 2010. View Article : Google Scholar : PubMed/NCBI

30. 

Nagao Y, Tomonari R, Kage M, Komai K, Tsubone K, Kamura T and Sata M: The possible intraspousal transmission of HCV in terms of lichen planus. Int J Mol Med. 10:569–573. 2002.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nagao Y and Sata M: Oral verrucous carcinoma arising from lichen planus and esophageal squamous cell carcinoma in a patient with hepatitis C virus-related liver cirrhosis-hyperinsulinemia and malignant transformation: A case report. Biomed Rep 1: 53-56, 2013.
APA
Nagao, Y., & Sata, M. (2013). Oral verrucous carcinoma arising from lichen planus and esophageal squamous cell carcinoma in a patient with hepatitis C virus-related liver cirrhosis-hyperinsulinemia and malignant transformation: A case report. Biomedical Reports, 1, 53-56. https://doi.org/10.3892/br.2012.14
MLA
Nagao, Y., Sata, M."Oral verrucous carcinoma arising from lichen planus and esophageal squamous cell carcinoma in a patient with hepatitis C virus-related liver cirrhosis-hyperinsulinemia and malignant transformation: A case report". Biomedical Reports 1.1 (2013): 53-56.
Chicago
Nagao, Y., Sata, M."Oral verrucous carcinoma arising from lichen planus and esophageal squamous cell carcinoma in a patient with hepatitis C virus-related liver cirrhosis-hyperinsulinemia and malignant transformation: A case report". Biomedical Reports 1, no. 1 (2013): 53-56. https://doi.org/10.3892/br.2012.14
Copy and paste a formatted citation
x
Spandidos Publications style
Nagao Y and Sata M: Oral verrucous carcinoma arising from lichen planus and esophageal squamous cell carcinoma in a patient with hepatitis C virus-related liver cirrhosis-hyperinsulinemia and malignant transformation: A case report. Biomed Rep 1: 53-56, 2013.
APA
Nagao, Y., & Sata, M. (2013). Oral verrucous carcinoma arising from lichen planus and esophageal squamous cell carcinoma in a patient with hepatitis C virus-related liver cirrhosis-hyperinsulinemia and malignant transformation: A case report. Biomedical Reports, 1, 53-56. https://doi.org/10.3892/br.2012.14
MLA
Nagao, Y., Sata, M."Oral verrucous carcinoma arising from lichen planus and esophageal squamous cell carcinoma in a patient with hepatitis C virus-related liver cirrhosis-hyperinsulinemia and malignant transformation: A case report". Biomedical Reports 1.1 (2013): 53-56.
Chicago
Nagao, Y., Sata, M."Oral verrucous carcinoma arising from lichen planus and esophageal squamous cell carcinoma in a patient with hepatitis C virus-related liver cirrhosis-hyperinsulinemia and malignant transformation: A case report". Biomedical Reports 1, no. 1 (2013): 53-56. https://doi.org/10.3892/br.2012.14
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team