Tofuyo (fermented soybean food) extract prolongs the survival of mice infected with influenza virus

Sakudo,Akikazu; Sesoko,Masayasu

doi:10.3892/br.2012.29

January-February 2013 Volume 1 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January-February 2013 Volume 1 Issue 1

Full Size Image

Article

Tofuyo (fermented soybean food) extract prolongs the survival of mice infected with influenza virus

Authors:
- Akikazu Sakudo
- Masayasu Sesoko
View Affiliations / Copyright

Affiliations: Laboratory of Biometabolic Chemistry, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0215, Japan, RyuKyu-Cement Co., Ltd., Urasoe, Okinawa 901-2123, Japan
Pages: 80-84
|
Published online on: October 25, 2012

https://doi.org/10.3892/br.2012.29
Expand metrics +

Abstract

Fermented soybean, known as tofuyo, is a traditional food in Okinawa (Japan). Tofuyo extract is obtained from the supernatant of fermented soybean after homogenization, filtration and centrifugation. In this study, we analyzed the in vitro effect of tofuyo extract on influenza virus using immunochromatography of the influenza virus nucleoprotein (NP). The results showed that tofuyo extract does not have a strong inhibitory effect on NP. This finding was confirmed by an assay for virus activity using embryonated eggs. To investigate the potential anti-influenza virus activity of tofuyo in vivo, 5 nude mice (BALB/cSlc-nu/nu) were administered drinking water supplemented with tofuyo extract the day prior to intranasal inoculation with influenza virus, while the control group (5 mice) was administered tofuyo extract‑free water. Control group mice (40%) were dead within 14 days, while the mice that were administered water containing tofuyo extract survived. Nutrient component analysis showed that tofuyo extract contains proteins, carbohydrates, vitamins and minerals that provide nutritional value, which may help to maintain good health.

View Figures

View References

1.	Kuba M, Tanaka K, Tawata S, Takeda Y and Yasuda M: Angiotensin I-converting enzyme inhibitory peptides isolated from tofuyo fermented soybean food. Biosci Biotechnol Biochem. 67:1278–1283. 2003. View Article : Google Scholar : PubMed/NCBI
2.	Yasuda M, Matsumoto T, Sakaguchi M and Kinjo S: Production of tofuyo using combination of red and yellow kojis. Nippon Shokuhin Kagaku Kogaku Kaishi. 42:38–43. 1995.(In Japanese).
3.	Sakudo A, Baba K, Tsukamoto M, Sugimoto A, Okada T, Kobayashi T, Kawashita N, Takagi T and Ikuta K: Anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads-based capture of human influenza A and B virus. Bioorg Med Chem. 17:752–757. 2009. View Article : Google Scholar : PubMed/NCBI
4.	Dobashi N, Yasui A and Wataanbe T: Basics of food analysis. Nutrition and Food Science Dictionary (The Japanese Society of Nutrition and Food Science). Yasumoto K, Takeuchi M, Yasui A and Watanabe T: Kenpakusha; Tokyo: pp. 1–58. 2006
5.	Kagawa Y: Explanation for standard tables of food composition. Standard Tables of Food Composition in Japan (Fifth Revised and Enlarged Edition). Kagawa Education Institute of Nutrition; Tokyo: pp. 2–3. 2010
6.	Sakudo A and Sesoko M: Effects of tofuyo (fermented soybean food) extract on influenza virus. Soy Protein Res (Japan). 14:146–149. 2011.
7.	Claft IL, Geddes D, Hyde CW, Wise IJ and Matthews DM: Absorption and malabsorption of glycine and glycine peptides in man. Gut. 9:425–437. 1968. View Article : Google Scholar : PubMed/NCBI
8.	Chun H, Sasaki M, Fujiyama Y and Bamba T: Effect of peptide chain length on absorption and intact transport of hydrolyzed soybean peptide in rat intestinal everted sac. J Clin Biochem Nutr. 21:131–140. 1996. View Article : Google Scholar
9.	Yasuda M and Morita M: Food-chemical research on tofu curd. Decomposition and antioxidative property of protein in maturation process. J Jpn Soc Nutr Food Sci. 52:3032010.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Tofuyo (fermented soybean food) extract prolongs the survival of mice infected with influenza virus

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Related Articles