Effects of recombinant human endostatin on the expression of vascular endothelial growth factor in human gastric cancer cell line MGC-803

Wang,Yu-Bin; Liu,Jun-Hong; Song,Zong-Min

doi:10.3892/br.2012.3

January-February 2013 Volume 1 Issue 1

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January-February 2013 Volume 1 Issue 1

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Article

Effects of recombinant human endostatin on the expression of vascular endothelial growth factor in human gastric cancer cell line MGC-803

Authors:
- Yu-Bin Wang
- Jun-Hong Liu
- Zong-Min Song
View Affiliations / Copyright

Affiliations: Department of General Surgery, The First Affiliated Hospital, Liaoning Medical University, Jinzhou 121001, P.R. China
Pages: 77-79
|
Published online on: August 13, 2012

https://doi.org/10.3892/br.2012.3
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Abstract

The present study aimed to explore the effects of recombinant human endostatin, endostar (ES), on the expression of vascular endothelial growth factor (VEGF) in the human gastric cancer cell line MGC-803. The expression of VEGF protein in MGC-803 cells was examined using immunohistochemistry. Subsequent to treatment with various concentrations of ES, the mRNA and VEGF protein expressions were determined in MGC-803 cells. A high level of VEGF protein expression was detected in MGC-803 cells. Subsequent to ES treatment, the mRNA and VEGF protein expressions were significantly decreased in MGC-803 cells (all P<0.05). In conclusion, ES is likely to inhibit the VEGF expression in MGC-803 cells.

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1.	He XW, Yu X, Liu T, Yu SY and Chen DJ: Vector-based RNA interference against vascular endothelial growth factor C inhibits tumor lymph angiogenesis and growth of colorectal cancer in vivo in mice. Chin Med J (Engl). 121:439–444. 2008.
2.	Satchi-Fainoaro R, Puder M, Davies JW, Tran HT, Sampson DA, Greene AK, Corfas G and Folkman J: Targeting angiogenesis with a conjugate of H PMA copolymer and TNP-470. Nat Med. 10:255–261. 2004. View Article : Google Scholar : PubMed/NCBI
3.	Tian XJ, Wu J and Meng L: Preparation of monoclonal antibodies to human vascular endothelial growth factor (VEGF 121) and identification of its expression on gastric carcinoma cell line MGC803. Zhonghua Zhong Liu Za Zhi. 21:93–95. 1999.(In Chinese).
4.	Luo XD, Xin Y and Xiao YP: Expression of VEGF and its receptors Flt-1 and KDR in gastric carcinoma and its significance. J Chin Med Univ. 37:760–763. 2008.(In Chinese).
5.	Xu HR, Tian W, Niu XH, Yuan RY, Zhang Q, Chen DF and Liu WF: In vitro study of recombinant human endostatin in combination with adriamycin on human osteosarcoma cell OS-732. Chin J Bone Tumor Bone Dis. 7:129–132. 2008.(In Chinese).
6.	Neskey DM, Ambesi A, Pumiglia KM and McKeown-Longo PJ: Endostatin and anastellin inhibit distinct aspects of the angiogenic process. J Exp Clin Cancer Res. 27:612008. View Article : Google Scholar : PubMed/NCBI
7.	Wu XZ: New strategy of antiangiogenic therapy for hepatocellular carcinoma. Neoplasma. 55:472–481. 2008.PubMed/NCBI
8.	Franco TH, Khan A, Joshi V and Thomas B: Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer. Ther Clin Risk Manag. 4:1367–1370. 2008.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of recombinant human endostatin on the expression of vascular endothelial growth factor in human gastric cancer cell line MGC-803

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