Salvianolic acid A positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells

Bi,Lei; Chen,Jianping; Yuan,Xiaojing; Jiang,Zequn; Chen,Weiping

doi:10.3892/br.2012.33

March-April 2013 Volume 1 Issue 2

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March-April 2013 Volume 1 Issue 2

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Article

Salvianolic acid A positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells

Authors:
- Lei Bi
- Jianping Chen
- Xiaojing Yuan
- Zequn Jiang
- Weiping Chen
View Affiliations / Copyright

Affiliations: The Associated Hospital of Nanjing University of Chinese Medicine, Nanjing 210046, P.R. China, College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, P.R. China
Pages: 213-217
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Published online on: October 29, 2012

https://doi.org/10.3892/br.2012.33
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Abstract

Salvianolic acid A (Sal A) is an effective compound extracted from Salvia miltiorrhiza which has been used in the treatment of various diseases. Preliminary data indicate that Sal A treatment has a specific anti‑lung cancer effect. However, the manner in which Sal A regulates cancer growth remains unknown. In this study, the A549 lung cancer cell line and its response to Sal A treatment was examined. Results showed that Sal A treatment significantly decreased A549 cell growth, promoted partial apoptosis and increased mitochondrial membrane permeability. Western blot analysis showed that Sal A upregulated the phosphatase and tensin homolog (PTEN) protein level, while consistently downregulating Akt phosphorylation. These results indicate that Sal A negatively mediates A549 lung cancer cell line growth or apoptosis, most likely by positively regulating PTEN protein level.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Salvianolic acid A positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells

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