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Article

Expression of DNMTs and MBD2 in GIST

  • Authors:
    • Miao He
    • Jing Fan
    • Rong Jiang
    • Wei-Xue Tang
    • Zi-Wei Wang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Laboratory of Stem Cell and Tissue Engineering, Institute of Basic Medicine of Chongqing Medical University, Chongqing 400016, P.R. China, Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 223-227
    |
    Published online on: October 29, 2012
       https://doi.org/10.3892/br.2012.34
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Abstract

The aim of this study was to investigate the protein expression of DNA methyltransferases (DNMTs, including DNMT1, DNMT2, DNMT3A, DNMT3B and DNMT3L) and methyl-CpG-binding domain protein 2 (MBD2) in gastrointestinal stromal tumor (GIST). Immunohistochemistry and western blot analysis were used to detect expression of DNMT and MBD2 in 15 pairs of adult GIST and matched non‑tumor tissues. The protein expression of DNMT1, DNMT2, DNMT3B, DNMT3L and MBD2 was significantly higher in adult GISTs compared to the matched non-tumor tissues (P<0.05). However, no significant difference was detected in the protein expression of DNMT3A between tumor and non‑tumor tissues (P>0.05). Associations between DNMT1 expression and mitotic index, DNMT3B expression and tumor size, as well as DNMT3L expression and Helicobacter pylori infection were detected in GISTs (P<0.05). In conclusion, GISTs exhibit a high protein expression of DNMT (with the exception of DNMT3A) and MBD2.
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Copy and paste a formatted citation
Spandidos Publications style
He M, Fan J, Jiang R, Tang W and Wang Z: Expression of DNMTs and MBD2 in GIST. Biomed Rep 1: 223-227, 2013.
APA
He, M., Fan, J., Jiang, R., Tang, W., & Wang, Z. (2013). Expression of DNMTs and MBD2 in GIST. Biomedical Reports, 1, 223-227. https://doi.org/10.3892/br.2012.34
MLA
He, M., Fan, J., Jiang, R., Tang, W., Wang, Z."Expression of DNMTs and MBD2 in GIST". Biomedical Reports 1.2 (2013): 223-227.
Chicago
He, M., Fan, J., Jiang, R., Tang, W., Wang, Z."Expression of DNMTs and MBD2 in GIST". Biomedical Reports 1, no. 2 (2013): 223-227. https://doi.org/10.3892/br.2012.34
Copy and paste a formatted citation
x
Spandidos Publications style
He M, Fan J, Jiang R, Tang W and Wang Z: Expression of DNMTs and MBD2 in GIST. Biomed Rep 1: 223-227, 2013.
APA
He, M., Fan, J., Jiang, R., Tang, W., & Wang, Z. (2013). Expression of DNMTs and MBD2 in GIST. Biomedical Reports, 1, 223-227. https://doi.org/10.3892/br.2012.34
MLA
He, M., Fan, J., Jiang, R., Tang, W., Wang, Z."Expression of DNMTs and MBD2 in GIST". Biomedical Reports 1.2 (2013): 223-227.
Chicago
He, M., Fan, J., Jiang, R., Tang, W., Wang, Z."Expression of DNMTs and MBD2 in GIST". Biomedical Reports 1, no. 2 (2013): 223-227. https://doi.org/10.3892/br.2012.34
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