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Article

Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease

  • Authors:
    • Mohamed S. Daoud
    • Farid S. Ataya
    • Dalia Fouad
    • Amal Alhazzani
    • Afaf I. Shehata
    • Abdulaziz A. Al‑Jafari
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, College of Science, King Saud University, Riyadh, Riyadh 11459, Saudi Arabia, Department of Zoology, College of Science, King Saud University, Riyadh, Riyadh 11451, Saudi Arabia, Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Riyadh 11451, Saudi Arabia
  • Pages: 573-582
    |
    Published online on: May 30, 2013
       https://doi.org/10.3892/br.2013.126
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Abstract

Lipoprotein lipase (LPL) plays a central role in lipoprotein metabolism by hydrolyzing the core triglycerides (TGs) of circulating chylomicrons and very‑low‑density lipoprotein (VLDL). The effects of LPL polymorphisms on lipid levels and coronary artery disease (CAD) have been inconsistent among studies and populations. To assess the lipid profiles and distributions of three LPL gene polymorphisms in Saudi patients with CAD, the HindIII, PvuII and Ser447Ter polymorphisms in the LPL gene were analyzed in 226 patients with CAD and 110 controls. Polymerase chain reaction‑restriction fragment length polymorphism was used to detect LPL gene polymorphisms. The plasma lipid profiles of the patients were determined using standard enzymatic methods. Patients in the CAD group had significantly higher triglyceride (TG), total cholesterol (TC) and low‑density lipoprotein cholesterol (LDL‑C) levels than controls irrespective of the HindIII, PvuII or Ser447Ter genotype. Compared to the findings in controls, the HindIII TT, PvuII TC and Ser447Ter CC genotypes were associated with significantly reduced high‑density lipoprotein cholesterol (HDL‑C) levels in patients with CAD (P<0.0001). In summary, there are associations between LPL gene variants and high plasma TG, TC and LDL‑C levels as well as low HDL‑C levels.
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1 

Al-Jafari AA and Cryer A: The lipoprotein lipase of white adipose tissue. Studies on the intracellular distribution of the adipocyte-associated enzyme. Biochem J. 236:749–756. 1986.PubMed/NCBI

2 

Auwerz J, Leroy P and Schoonjans K: Lipoprotein lipase: recent contributions from molecular biology. Crit Rev Clin Lab Sci. 29:243–268. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Saxena U, Klein MG, Vanni TM and Goldberg IJ: Lipoprotein lipase increases low density lipoprotein retention by subendothelial cell matrix. J Clin Invest. 89:373–380. 1992. View Article : Google Scholar : PubMed/NCBI

4 

Goldbourt U, Yaari S and Medalie JH: Isolated low HDL cholesterol as a risk factor for coronary heart disease mortality. A 21-year follow-up of 8000 men. Arterioscler Thromb Vasc Biol. 17:107–113. 1997.PubMed/NCBI

5 

Stephens JW and Humphries SE: The molecular genetics of cardiovascular disease: clinical implications. J Intern Med. 253:120–127. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Su Z, Zhang S, Hou Y, Zhang Li, Liao L and Xiao C: Relationship between a novel polymorphism of lipoprotein lipase gene and coronary heart disease. Chin Med J (Engl). 115:677–680. 2002.PubMed/NCBI

7 

Anderson JL, King GJ, Bair TL, Elmer SP, Muhlestein JB, Habashi J, Mixson L and Carlquist JF: Association of lipoprotein lipase gene polymorphism with coronary artery disease. J Am Coll Cardiol. 33:1013–1020. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Sagoo GS, Tatt I, Salanti G, Butterworth AS, Sarwar N, van Maarle M, Jukema JW, Wiman B, Kastelein JJ, Bennet AM, et al: Seven lipoprotein gene polymorphisms, lipid fractions, and coronary disease: A HuGE association review and meta-analysis. Am J Epidemiol. 168:1233–1246. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Emi M, Wilson DE, Iverius PH, Wu L, Hata A, Hegele R, Williams RR and Lalouel JM: Missense mutations (Gly - Glu 188) of human lipoprotein lipase imparting functional deficiency. J Biol Chem. 10:5910–5916. 1990.PubMed/NCBI

10 

Hallman DM, Groenemeijer BE, Jukema JW, Boerwinkle E and Kastelein JJ: Analysis of lipoprotein lipase haplotypes reveals associations not apparent from analysis of the constituent loci. Ann Hum Genet. 63:499–510. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Hu Y, Liu W, Huang R and Zhang X: A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases. J Lipid Res. 47:1908–1914. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Wittrup HH, Tybjaerg-Hansen A and Nordestgaard BG: Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis. Circulation. 99:2901–2907. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Socquard E, Durlach A, Clavel C, Nazeyrollas P and Durlach V: Association of HindIII and PvuII genetic polymorphisms of lipo-protein lipase with lipid metabolism and macrovascular events in type 2 diabetic patients. Diabetes Metab. 32:262–269. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Gigek Cde O, Chen ES, Cendoroglo MS, Ramos LR, Araujo LM, Payao SL and Smith Mde A: Association of lipoprotein lipase polymorphisms with myocardial infarction and lipid levels. Clin Chem Lab Med. 45:599–604. 2007.PubMed/NCBI

15 

McGladdery SH, Pimstone SN, Clee SM, Bowden JF, Hayden MR and Frohlich JJ: Common mutations in the lipoprotein lipase gene (LPL): effects on HDL-cholesterol levels in a Chinese Canadian population. Atherosclerosis. 156:401–407. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Brousseau ME, Goldkamp AL, Collins D, Demissie S, Connolly AC, Cupples LA, Ordovas JM, Bloomfield HE, Robins SJ and Schaefer EJ: Polymorphisms in the gene encoding lipoprotein lipase in men with low HDL-C and coronary heart disease: the Veterans Affairs. HDL Intervention. Trial J Lipid Res. 45:1885–1891. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Ferencak G, Pasalic D, Grskovic B, Cheng S, Fijal B, Sesto M, Skodlar J and Rukavina AS: Lipoprotein lipase gene polymorphisms in Croatian patients with coronary artery disease. Clin Chem Lab Med. 41:541–546. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Sawano M, Watanabe Y, Ohmura H, Shimada K, Diada H, Mokuno H and Yamaguchi H: Potentailly protective effects of the Ser447-Ter mutation of the lipoprotein lipase gene against the development of coronary artery disease in Japanese subjects via a beneficial lipid profile. Jpn Circ J. 65:310–314. 2001. View Article : Google Scholar

19 

Shimo-Nakanishi Y, Urabe T, Hattori N, Watanabe Y, Nagao T, Yokochi M, Hamamoto M and Mizuno Y: Polymorphism of the lipoprotein lipase gene and risk of atherothrombotic cerebral infarction in the Japanese. Stroke. 32:1481–1486. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Fisher RM, Humphries SE and Talmud PJ: Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis. Atherosclerosis. 135:145–159. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Murthy V, Julien P and Gagne C: Molecular pathobiology of the human lipoprotein lipase gene. Pharmacol Ther. 70:101–135. 1996. View Article : Google Scholar : PubMed/NCBI

22 

Gensini GF, Comeglio M and Colella A: Classical risk factors and emerging elements in the risk profile for coronary artery disease. Eur Heart J. 19:A53–A61. 1998.PubMed/NCBI

23 

Hirashiki A, Yamada Y, Murase Y, Suzuki Y, Kataoka H, Morimoto Y, Tajika T, Murohara T and Yokota M: Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. J Am Coll Cardiol. 42:1429–1437. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Duman BS, Turkoglu C, Akpınar B, Guden M, Vertii A, Dak E, Cagatay P, Gunay D and Buyukdevrim AS: Lipoprotein lipase gene polymorphism and lipid profile in coronary artery disease. Arch Pathol Lab Med. 128:869–974. 2004.PubMed/NCBI

25 

Ahn YI, Kamboh MI, Hamman RF, Cole SA and Ferrell RE: Two DNA polymorphisms in the lipoprotein lipase gene and their associations with factors related to cardiovascular disease. J Lipid Res. 34:421–428. 1993.PubMed/NCBI

26 

Shagisultanova EI, Mustafina OE, Tuktarova IA and Khusnutdinova EK: HindIII polymorphism of lipoprotein lipase gene and risk of myocardial infarction. Mol Gen Mikrobiol Virusol. 3:18–22. 2001.(In Russian).

27 

Rebhi L, Kchok K, Omezzine A, Kacem S, Rejeb J, Ben HadjMbarek I, Belkahla R, Boumaiza I, Moussa A, Ben Rejeb N, et al: Six lipoprotein lipase gene polymorphisms, lipid profile and coronary stenosis in a Tunisian population. Mol Biol Rep. 39:9893–9901. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Peacock RE, Hamsten A, Nilsson-Ehle P and Humphries SE: Associations between lipoprotein lipase gene polymorphisms and plasma correlations of lipids, lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden. Atherosclerosis. 97:171–185. 1992. View Article : Google Scholar

29 

Thorn JA, Chamberlain JC, Alcolado JC, Oka K, Chan L, Stocks J and Galton DJ: Lipoprotein and hepatic lipase gene variants in coronary atherosclerosis. Atherosclerosis. 85:55–60. 1990. View Article : Google Scholar : PubMed/NCBI

30 

Chamberlain JC, Thorn JA, Oka K, Galton DJ and Stocks J: DNA polymorphisms at the lipoprotein lipase gene: associations in normal and hypertriglyceridaemic subjects. Atherosclerosis. 79:85–91. 1989. View Article : Google Scholar : PubMed/NCBI

31 

Heinzmann C, Kirchgessner T, Kwiterovich PO, Ladias JA, Derby C, Antonarakis SE and Lusis AJ: DNA polymorphism haplotypes of the human lipoprotein lipase gene: possible association with high-density lipoprotein levels. Hum Genet. 86:578–584. 1991.PubMed/NCBI

32 

Mattu RK, Needham EW, Morgan R, Rees A, Hackshaw AK, Stocks J, Elwood PC and Galton DJ: DNA variants at the LPL gene locus associate with angiographically defined severity of atherosclerosis and serum lipoprotein levels in a Welsh population. Arterioscler Thromb. 14:1090–1097. 1994. View Article : Google Scholar : PubMed/NCBI

33 

Chamberlain JC, Thorn JA, Morgan R, Bishop A, Stocks J, Rees A, Oka K and Galton DJ: Genetic variation at the lipoprotein lipase gene associates with coronary arteriosclerosis. Adv Exp Med Biol. 285:275–279. 1991. View Article : Google Scholar : PubMed/NCBI

34 

Corella D, Guillen M, Saiz C, Portoles O, Sabater A, Folch J and Ordovas JM: Associations of LPL and APOC3 gene polymorphisms on plasma lipids in a Mediterranean population: interaction with tobacco smoking and the APOE locus. J Lipid Res. 43:416–427. 2002.PubMed/NCBI

35 

Razzaghi H, Aston CE, Hamman RF and Kamboh MI: Genetic screening of the lipoprotein lipase gene for mutations associated with high triglyceride/low HDL-cholesterol levels. Hum Genet. 107:257–267. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Komurcu-Bayrak E, Onat A, Poda M, Humphries SE, Acharya J, Hergenc G, Coban N, Can G and Erginel-Unaltuna N: The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks. Clin Chim Acta. 383:110–115. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Abu-Amero KK, Wyngaard CA, Al-Boudari OM, Kambouris M and Dzimiri N: Lack of association of lipoprotein lipase gene polymorphisms with coronary artery disease in the Saudi Arab population. Arch Pathol Lab Med. 127:597–600. 2003.PubMed/NCBI

38 

Clee SM, Bissada N, Miao F, Miao L, Marais AD, Henderson HE, Steures P, McManus J, McManus B, LeBoeuf RC, et al: Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. J Lipid Res. 41:521–531. 2000.PubMed/NCBI

39 

Lee J, Tan CS, Chia KS, Tan CE, Chew SK, Ordovas JM and Tai ES: The lipoprotein lipase S447X polymorphism and plasma lipids: interactions with APOE polymorphisms, smoking, and alcohol consumption. J Lipid Res. 45:1132–1139. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Wung SF, Kulkarni MV, Pullinger CR, Malloy MJ, Kane JP and Aouizerat BE: The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion. Lipids Health Dis. 5:192006. View Article : Google Scholar : PubMed/NCBI

41 

Chen Q, Razzaghi H, Demirci FY and Kamboh MI: Functional significance of lipoprotein lipase HindIII polymorphism associated with the risk of coronary artery disease. Atherosclerosis. 200:102–108. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Wang XL, McCredie RM and Wilcken DE: Common DNA polymorphisms at the lipoprotein lipase gene. Association with severity of coronary artery disease and diabetes. Circulation. 93:1339–1345. 1996. View Article : Google Scholar : PubMed/NCBI

43 

Georges JL, Regis-Bailly A, Salah D, Rakotovao R, Siest G, Visvikis S and Tiret L: Family study of lipoprotein lipase gene polymorphisms and plasma triglyceride levels. Genet Epidemiol. 13:179–192. 1996. View Article : Google Scholar : PubMed/NCBI

44 

Yamana K, Yanagi H, Hirano C, Kobayashi K, Tanaka M, Tomura S, Tsuchiya S and Hamaguchi H: Genetic polymorphisms and mutations of lipoprotein lipase gene in Japanese schoolchildren with hypoalphaalipoproteinemia. J Atheroscler Thromb. 4:97–101. 1998. View Article : Google Scholar : PubMed/NCBI

45 

Ye P, Pei L and Wang S: Polymorphisms of the human lipoprotein lipase gene: possible association with lipid levels in patients with coronary heart disease in Beijing area. Chin Med Sci J. 11:157–161. 1996.PubMed/NCBI

46 

Jemaa R, Tuzet S, Portos C, Betoulle D, Apfelbaum M and Fumeron F: Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people. Int J Obes Relat Metab Disord. 19:270–274. 1995.PubMed/NCBI

47 

Humphries SE, Nicaud V, Margalef J, Tiret L and Talmud PJ: Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS). Arterioscler Thromb Vasc Biol. 18:526–534. 1998. View Article : Google Scholar

48 

Henderson HE, Kastelein JJ, Zwinderman AH, Gagne E, Jukema JW, Reymer PW, Groenemeyer BE, Lie KI, Bruschke AV, Hayden MR and Jansen H: Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins. J Lipid Res. 40:735–743. 1999.PubMed/NCBI

49 

Gagne SE, Larson MG, Pimstone SN, Schaefer EJ, Kastelein JJ, Wilson PW, Ordovas JM and Hayden MR: A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study. Clin Genet. 55:450–454. 1999. View Article : Google Scholar

50 

Groenemeijer BE, Hallman MD, Reymer PW, Gagne E, Kuivenhoven JA, Bruin T, Jansen H, Lie KI, Bruschke AV, Boerwinkle E, et al: Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients. The Ser447-stop substitution in the lipoprotein lipase gene. REGRESS Study Group. Circulation. 95:2628–2635. 1997.

51 

Alper AT, Hasdemir H, Sahin S, Onturk E, Akyol A, Nurkalem Z, Cakmak N, Erdinler I and Gurkan K: The relationship between nonalcoholic fatty liver disease and the severity of coronary artery disease in patients with metabolic syndrome. Turk Kardiyol Dern Ars. 36:376–381. 2008.

52 

Goodarzi MO, Guo X, Taylor KD, Quinones MJ, Samayoa C, Yang H, Saad MF, Palotie A, Krauss RM, Hsueh WA and Rotter JI: Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans. Genet Med. 5:322–327. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Daoud MS, Ataya FS, Fouad D, Alhazzani A, Shehata AI and Al‑Jafari AA: Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease. Biomed Rep 1: 573-582, 2013.
APA
Daoud, M.S., Ataya, F.S., Fouad, D., Alhazzani, A., Shehata, A.I., & Al‑Jafari, A.A. (2013). Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease. Biomedical Reports, 1, 573-582. https://doi.org/10.3892/br.2013.126
MLA
Daoud, M. S., Ataya, F. S., Fouad, D., Alhazzani, A., Shehata, A. I., Al‑Jafari, A. A."Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease". Biomedical Reports 1.4 (2013): 573-582.
Chicago
Daoud, M. S., Ataya, F. S., Fouad, D., Alhazzani, A., Shehata, A. I., Al‑Jafari, A. A."Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease". Biomedical Reports 1, no. 4 (2013): 573-582. https://doi.org/10.3892/br.2013.126
Copy and paste a formatted citation
x
Spandidos Publications style
Daoud MS, Ataya FS, Fouad D, Alhazzani A, Shehata AI and Al‑Jafari AA: Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease. Biomed Rep 1: 573-582, 2013.
APA
Daoud, M.S., Ataya, F.S., Fouad, D., Alhazzani, A., Shehata, A.I., & Al‑Jafari, A.A. (2013). Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease. Biomedical Reports, 1, 573-582. https://doi.org/10.3892/br.2013.126
MLA
Daoud, M. S., Ataya, F. S., Fouad, D., Alhazzani, A., Shehata, A. I., Al‑Jafari, A. A."Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease". Biomedical Reports 1.4 (2013): 573-582.
Chicago
Daoud, M. S., Ataya, F. S., Fouad, D., Alhazzani, A., Shehata, A. I., Al‑Jafari, A. A."Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease". Biomedical Reports 1, no. 4 (2013): 573-582. https://doi.org/10.3892/br.2013.126
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