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Article

Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease

  • Authors:
    • Seema Zargar
    • Salma Wakil
    • Abduelah F. Mobeirek
    • Abdulaziz A. Al‑Jafari
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia, King Faisal Specialist Hospital and Research Centre, Riyadh 11451, Saudi Arabia, Cardiac Sciences Department, Faculty of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
  • Pages: 883-888
    |
    Published online on: September 2, 2013
       https://doi.org/10.3892/br.2013.163
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Abstract

Coronary artery disease (CAD) is one of the leading causes of mortality in developed countries. Adenosine triphosphate (ATP)‑binding cassette A1 (ABCA1) belongs to the superfamily of membrane proteins that function as a key factor in the regulation of plasma high‑density lipoprotein cholesterol (HDL‑C) and the metabolism of apolipoprotein A‑I (Apo AI). The role of this gene in CAD remains controversial. The aim of this study was to investigate the frequency of single‑nucleotide polymorphism (SNP) rs2230806 in the ABCA1 gene of 120 CAD patients and 100 age‑matched, healthy controls using restriction fragment length polymorphism and direct sequencing. Total serum cholesterol, HDL‑C and serum triglyceride levels were also assayed. Low‑density lipoprotein cholesterol (LDL‑C) was calculated using the Friedewald formula. When compared, the G allele occurred significantly more frequently in CAD patients compared to the control subjects. The odds ratio (OR) for CAD conferred by carrying the ABCA1 G allele was 2.362 [95% confidence interval (CI) 0.9055‑6.161] (P<0.08). The K variant of SNP rs2230806 in the G allele was associated with a decrease in HDL‑C levels, but an increased frequency of CAD. In conclusion, the results showed that SNP rs2230806 in the ABCA1 gene is significantly associated with the incidence of CAD. Homozygosity for the G allelic variant in CAD patients may be associated with an increased risk of CAD/MI.
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Copy and paste a formatted citation
Spandidos Publications style
Zargar S, Wakil S, Mobeirek AF and Al‑Jafari AA: Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease. Biomed Rep 1: 883-888, 2013.
APA
Zargar, S., Wakil, S., Mobeirek, A.F., & Al‑Jafari, A.A. (2013). Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease. Biomedical Reports, 1, 883-888. https://doi.org/10.3892/br.2013.163
MLA
Zargar, S., Wakil, S., Mobeirek, A. F., Al‑Jafari, A. A."Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease". Biomedical Reports 1.6 (2013): 883-888.
Chicago
Zargar, S., Wakil, S., Mobeirek, A. F., Al‑Jafari, A. A."Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease". Biomedical Reports 1, no. 6 (2013): 883-888. https://doi.org/10.3892/br.2013.163
Copy and paste a formatted citation
x
Spandidos Publications style
Zargar S, Wakil S, Mobeirek AF and Al‑Jafari AA: Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease. Biomed Rep 1: 883-888, 2013.
APA
Zargar, S., Wakil, S., Mobeirek, A.F., & Al‑Jafari, A.A. (2013). Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease. Biomedical Reports, 1, 883-888. https://doi.org/10.3892/br.2013.163
MLA
Zargar, S., Wakil, S., Mobeirek, A. F., Al‑Jafari, A. A."Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease". Biomedical Reports 1.6 (2013): 883-888.
Chicago
Zargar, S., Wakil, S., Mobeirek, A. F., Al‑Jafari, A. A."Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease". Biomedical Reports 1, no. 6 (2013): 883-888. https://doi.org/10.3892/br.2013.163
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