Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-August 2014 Volume 2 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2014 Volume 2 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Pharmacokinetics of liver?targeted docetaxel liposomes modified with 6?O?acyl?D?galactose esters in rabbits

  • Authors:
    • Wei Wu
    • Yi Cheng
    • Bo‑Hong Guo
    • Qiong Wu
  • View Affiliations / Copyright

    Affiliations: School of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China
  • Pages: 545-548
    |
    Published online on: May 20, 2014
       https://doi.org/10.3892/br.2014.285
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of the present study was to investigate the pharmacokinetics of docetaxel liposomes modified with 6?O?acyl?D?galactose esters (Gal?DOC?L) in rabbits. A simple, rapid and sensitive high?performance liquid chromatography (HPLC) method was developed for the determination of docetaxel. Gal?DOC?L was intravenously administered to rabbits with norethisterone as the internal standard and the blood samples were collected from ear marginal veins at 0.083, 0.25, 0.5, l, 2, 4, 6, 8, 12, 16 and 24 h after treatment. The plasma concentration of docetaxel was determined by HPLC and the pharmacokinetic parameters were calculated. Docetaxel injection (DOC?I) was studied simultaneously. The results showed that the area under the curve(0??), t1/2? and t1/2? of Gal?DOC?L was significantly higher, while the total body clearance was lower than that of DOC?I. The results indicated that Gal?DOC?L was able to maintain a relatively high blood concentration in vivo and prolong the treatment time.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Samad A, Sultana Y and Aqil M: Liposomal drug delivery systems: an update review. Curr Drug Deliv. 4:297–305. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Gabizon A, Shmeeda H and Barenholz Y: Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies. Clin Pharmacokinet. 42:419–436. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Woodle MC and Lasic DD: Sterically stabilized liposomes. Biochim Biophys Acta. 1113:171–199. 1992. View Article : Google Scholar : PubMed/NCBI

4 

Allen TM, Hansen CB and de Menezes DEL: Pharmacokinetics of long-circulating liposomes. Adv Drug Deliv Rev. 16:267–284. 1995. View Article : Google Scholar

5 

Cai L, Wang X, Wang W, et al: Peptide ligand and PEG-mediated long-circulating liposome targeted to FGFR overexpressing tumor in vivo. Int J Nanomedicine. 7:4499–4510. 2012.PubMed/NCBI

6 

Mamidyala SK, Dutta S, Chrunyk BA, et al: Glycomimetic ligands for the human asialoglycoprotein receptor. J Am Chem Soc. 134:1978–1981. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Ye Z, Houssein HS and Mahato RI: Bioconjugation of oligonucleotides for treating liver fibrosis. Oligonucleotides. 17:349–404. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Li Y, Huang G, Diakur J and Wiebe LI: Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv. 5:299–302. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Zhou X, Zhang M, Yung B, Li H, Zhou C, Lee LJ and Lee RJ: Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma. Int J Nanomedicine. 7:5465–5474. 2012.PubMed/NCBI

10 

Cheng Y, Wu W, Zhang D and Mai YZ: Enzyme-catalyzed synthesis of ASGPR ligand-targeted modifier in non-aqueous medium. Acta Pharmaceutica Sinica. 45:1134–1138. 2010.(In Chinese).

11 

Guo BH, Cheng Y, Lin LP, Lin DH and Wu W: Preparation and characterization of galactose-modified liposomes by a nonaqueous enzymatic reaction. J Liposome Res. 21:255–260. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Kuyukina MS, Ivshina IB, Philp JC, Christofi N, Dunbar SA and Ritchkova MI: Recovery of Rhodococcus biosurfactants using methyl tertiary-butyl ether extraction. J Microbiol Methods. 46:149–156. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Matyash V, Liebisch G, Kurzchalia TV, Shevchenko A and Schwudke D: Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J Lipid Res. 49:1137–1146. 2008. View Article : Google Scholar : PubMed/NCBI

14 

FDA C: Guidance for industry: bioanalytical method validation. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CV); 2001

15 

Immordino ML, Dosio F and Cattel L: Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomedicine. 1:297–315. 2006.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu W, Cheng Y, Guo BH and Wu Q: Pharmacokinetics of liver?targeted docetaxel liposomes modified with 6?O?acyl?D?galactose esters in rabbits. Biomed Rep 2: 545-548, 2014.
APA
Wu, W., Cheng, Y., Guo, B., & Wu, Q. (2014). Pharmacokinetics of liver?targeted docetaxel liposomes modified with 6?O?acyl?D?galactose esters in rabbits. Biomedical Reports, 2, 545-548. https://doi.org/10.3892/br.2014.285
MLA
Wu, W., Cheng, Y., Guo, B., Wu, Q."Pharmacokinetics of liver?targeted docetaxel liposomes modified with 6?O?acyl?D?galactose esters in rabbits". Biomedical Reports 2.4 (2014): 545-548.
Chicago
Wu, W., Cheng, Y., Guo, B., Wu, Q."Pharmacokinetics of liver?targeted docetaxel liposomes modified with 6?O?acyl?D?galactose esters in rabbits". Biomedical Reports 2, no. 4 (2014): 545-548. https://doi.org/10.3892/br.2014.285
Copy and paste a formatted citation
x
Spandidos Publications style
Wu W, Cheng Y, Guo BH and Wu Q: Pharmacokinetics of liver?targeted docetaxel liposomes modified with 6?O?acyl?D?galactose esters in rabbits. Biomed Rep 2: 545-548, 2014.
APA
Wu, W., Cheng, Y., Guo, B., & Wu, Q. (2014). Pharmacokinetics of liver?targeted docetaxel liposomes modified with 6?O?acyl?D?galactose esters in rabbits. Biomedical Reports, 2, 545-548. https://doi.org/10.3892/br.2014.285
MLA
Wu, W., Cheng, Y., Guo, B., Wu, Q."Pharmacokinetics of liver?targeted docetaxel liposomes modified with 6?O?acyl?D?galactose esters in rabbits". Biomedical Reports 2.4 (2014): 545-548.
Chicago
Wu, W., Cheng, Y., Guo, B., Wu, Q."Pharmacokinetics of liver?targeted docetaxel liposomes modified with 6?O?acyl?D?galactose esters in rabbits". Biomedical Reports 2, no. 4 (2014): 545-548. https://doi.org/10.3892/br.2014.285
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team