Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies

  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-August 2014 Volume 2 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2014 Volume 2 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise

  • Authors:
    • Alyson Pin‑Tsz Tseng
    • Hannah Wei
    • Nicole Hsiung
    • Ssu‑Hua Chen
    • Hsuan‑Ying Chen
    • Fu‑Chou Cheng

  • View Affiliations / Copyright

    Affiliations: Stem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan, R.O.C.
  • Pages: 599-601
    |
    Published online on: May 21, 2014
       https://doi.org/10.3892/br.2014.289
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Serum magnesium (Mg) levels are closely controlled through a variety of Mg transporters and ionic channels during physiological conditions. These levels have been shown to increase during exercise. However, the effect of Mg transporter expression during exercise remains to be determined. The purpose of this study was to examine the gene expression of SLC41A1, a Na+/Mg2+ exchanger, during exercise. In the present study, male C57BL/6JNarl mice (n=16, 8 weeks old) were subjected to 3 h forced exercise on a treadmill. The mice in the control and Mg groups were injected with saline and Mg (MgSO4, 90 mg/kg, intraperitoneal), respectively. Blood samples were obtained at three time points: prior to, following and 24 h after exercise. The gene expression levels of SLC41A1 were significantly downregulated to 23.6±4.6 and 12.6±10.2% following exercise in the control and Mg groups, respectively. The expression levels returned to the basal levels 24 h after exercise in the two groups and there was no significant difference found between the two groups. The downregulated role of SLC41A1 expression and its interaction with the Mg status in exercise requires further investigation.
View Figures

Figure 1

View References

1 

Finstad EW, Newhouse IJ, Lukaski HC, et al: The effects of magnesium supplementation on exercise performance. Med Sci Sports Exerc. 33:493–498. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Romani AM: Cellular magnesium homeostasis. Arch Biochem Biophys. 512:1–23. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Cinar V, Polat Y, Mogulkoc R, et al: The effect of magnesium supplementation on glucose and insulin levels of tae-kwan-do sportsmen and sedentary subjects. Pak J Pharm Sci. 21:237–240. 2008.PubMed/NCBI

4 

Bohl CH and Volpe SL: Magnesium and exercise. Crit Rev Food Sci Nutr. 42:533–563. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Chen YJ, Chen HY, Wang MF, et al: Effects of magnesium on exercise performance and plasma glucose and lactate concentrations in rats using a novel blood-sampling technique. Appl Physiol Nutr Metab. 34:1040–1047. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Cheng SM, Yang LL, Chen SH, et al: Magnesium sulfate enhances exercise performance and manipulates dynamic changes in peripheral glucose utilization. Eur J Appl Physiol. 108:363–369. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Wabakken T, Rian E, Kveine M and Aasheim HC: The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+transporters. Biochem Biophys Res Commun. 306:718–724. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Goytain A and Quamme GA: Functional characterization of human SLC41A1, a Mg2+transporter with similarity to prokaryotic MgtE Mg2+transporters. Physiol Genomics. 21:337–342. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Kolisek M, Launay P, Beck A, et al: SLC41A1 is a novel mammalian Mg2+carrier. J Biol Chem. 283:16235–16247. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Mandt T, Song Y, Scharenberg AM and Sahni J: SLC41A1 Mg(2+) transport is regulated via Mg(2+)-dependent endosomal recycling through its N-terminal cytoplasmic domain. Biochem J. 439:129–139. 2011.

11 

Kolisek M, Nestler A, Vormann J and Schweigel-Röntgen M: Human gene SLC41A1 encodes for the Na+/Mg(2)+ exchanger. Am J Physiol Cell Physiol. 302:C318–C326. 2012.PubMed/NCBI

12 

Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e452001. View Article : Google Scholar : PubMed/NCBI

13 

Nestler A, Rylander R, Kolisek M, et al: Blood pressure in pregnancy and magnesium sensitive genes. Preg Hyper: An Int J Women’s Card Health. 4:41–45. 2014.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tseng AP, Wei H, Hsiung N, Chen SH, Chen HY and Cheng FC: SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise. Biomed Rep 2: 599-601, 2014.
APA
Tseng, A.P., Wei, H., Hsiung, N., Chen, S., Chen, H., & Cheng, F. (2014). SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise. Biomedical Reports, 2, 599-601. https://doi.org/10.3892/br.2014.289
MLA
Tseng, A. P., Wei, H., Hsiung, N., Chen, S., Chen, H., Cheng, F."SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise". Biomedical Reports 2.4 (2014): 599-601.
Chicago
Tseng, A. P., Wei, H., Hsiung, N., Chen, S., Chen, H., Cheng, F."SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise". Biomedical Reports 2, no. 4 (2014): 599-601. https://doi.org/10.3892/br.2014.289
Copy and paste a formatted citation
x
Spandidos Publications style
Tseng AP, Wei H, Hsiung N, Chen SH, Chen HY and Cheng FC: SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise. Biomed Rep 2: 599-601, 2014.
APA
Tseng, A.P., Wei, H., Hsiung, N., Chen, S., Chen, H., & Cheng, F. (2014). SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise. Biomedical Reports, 2, 599-601. https://doi.org/10.3892/br.2014.289
MLA
Tseng, A. P., Wei, H., Hsiung, N., Chen, S., Chen, H., Cheng, F."SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise". Biomedical Reports 2.4 (2014): 599-601.
Chicago
Tseng, A. P., Wei, H., Hsiung, N., Chen, S., Chen, H., Cheng, F."SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise". Biomedical Reports 2, no. 4 (2014): 599-601. https://doi.org/10.3892/br.2014.289
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team