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Article

Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation

  • Authors:
    • Rong Ju
    • Wen Zeng
    • Rong Wu
    • Zhichun Feng
  • View Affiliations / Copyright

    Affiliations: Department of Neonatology, Chengdu Women's and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, P.R. China, Neonatal Medical Center, Huaian Maternity and Child Healthcare Hospital Affiliated to Yangzhou University Medical Academy, Huaian, Jiangsu 223002, P.R. China, Department of Neonatology, Bayi Children's Hospital Affiliated to General Hospital of Beijing Military Command, Beijing 100700, P.R. China
  • Pages: 242-246
    |
    Published online on: December 17, 2014
       https://doi.org/10.3892/br.2014.405
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Abstract

Due to their capacity to self‑replicate or produce specific differentiated cell types, neural stem cells (NSCs) and bone marrow derived‑mesenchymal stem cells (BMSCs) are potential sources for cell transplantation therapies, particularly for neural injury. However, the interaction between NSCs and BMSCs during differentiation has not yet been defined. The interaction is believed to improve the effectiveness and efficiency of cell therapy. In the present study, human NSCs and BMSCs were cultured and the Transwell co‑culture system was used to observe the interplay between NSCs and BMSCs during differentiation. The results revealed that NSCs promoted BMSCs to differentiate into neurons and NSCs; whereas, BMSCs did not affect the differentiation of NSCs. Simultaneously, co‑culture increased the concentration of brain‑derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are secreted by NSCs and BMSCs. The present findings suggest that co‑culture of NSCs and BMSCs can promote the differentiation and this process may be modulated by BDNF and NGF.
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Copy and paste a formatted citation
Spandidos Publications style
Ju R, Zeng W, Wu R and Feng Z: Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation. Biomed Rep 3: 242-246, 2015.
APA
Ju, R., Zeng, W., Wu, R., & Feng, Z. (2015). Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation. Biomedical Reports, 3, 242-246. https://doi.org/10.3892/br.2014.405
MLA
Ju, R., Zeng, W., Wu, R., Feng, Z."Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation". Biomedical Reports 3.2 (2015): 242-246.
Chicago
Ju, R., Zeng, W., Wu, R., Feng, Z."Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation". Biomedical Reports 3, no. 2 (2015): 242-246. https://doi.org/10.3892/br.2014.405
Copy and paste a formatted citation
x
Spandidos Publications style
Ju R, Zeng W, Wu R and Feng Z: Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation. Biomed Rep 3: 242-246, 2015.
APA
Ju, R., Zeng, W., Wu, R., & Feng, Z. (2015). Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation. Biomedical Reports, 3, 242-246. https://doi.org/10.3892/br.2014.405
MLA
Ju, R., Zeng, W., Wu, R., Feng, Z."Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation". Biomedical Reports 3.2 (2015): 242-246.
Chicago
Ju, R., Zeng, W., Wu, R., Feng, Z."Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation". Biomedical Reports 3, no. 2 (2015): 242-246. https://doi.org/10.3892/br.2014.405
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