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Article

Association between MMP-2 expression and prostate cancer: A meta-analysis

  • Authors:
    • Tiancheng Xie
    • Binbin Dong
    • Yangye Yan
    • Guanghui Hu
    • Yunfei Xu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
  • Pages: 241-245
    |
    Published online on: December 8, 2015
       https://doi.org/10.3892/br.2015.553
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Abstract

Matrix metalloproteinase‑2 (MMP‑2) is a member of the MMP family, which is associated with numerous types of cancer. Although it has been widely reported, the prognostic value of MMP‑2 expression in prostate cancer (PCa) remains controversial. Thus, the present meta‑analysis was conducted to investigate the association and prognostic value of MMP‑2 expression in PCa. PubMed, Cochrane Library and the China National Knowledge Infrastructure databases were searched for all the published case‑control studies on the association between MMP‑2 expression and PCa until July 2015. The odd ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association of MMP‑2 expression and PCa. ORs and 95% CIs were applied to clarify this association. Several subgroup analyses were also conducted according to different indexes in the case group. In total, 8 studies including 675 patients were included in the final meta‑analysis. The results of the meta‑analysis showed that MMP‑2 expression in the PCa group was significantly higher than that in the benign prostatic hyperplasia (BPH) group (95% CI, 0.06‑0.15; Z=10.48; P<0.00001). Furthermore, MMP‑2 expression was significantly associated with Gleason Score (95% CI, 0.18‑0.68; Z=3.09; P=0.002) and clinical stages (95% CI, 0.12‑0.82; Z=2.36; P=0.02), and not significantly associated with Gleason score serum prostate specific antigen (95% CI, 0.30‑1.66; Z=0.80; P=0.43). In conclusion, MMP‑2 is overexpressed in PCa tissues compared with BPH. The expression of MMP‑2 was significantly associated with the grade of PCa malignancy.
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Copy and paste a formatted citation
Spandidos Publications style
Xie T, Dong B, Yan Y, Hu G and Xu Y: Association between MMP-2 expression and prostate cancer: A meta-analysis. Biomed Rep 4: 241-245, 2016.
APA
Xie, T., Dong, B., Yan, Y., Hu, G., & Xu, Y. (2016). Association between MMP-2 expression and prostate cancer: A meta-analysis. Biomedical Reports, 4, 241-245. https://doi.org/10.3892/br.2015.553
MLA
Xie, T., Dong, B., Yan, Y., Hu, G., Xu, Y."Association between MMP-2 expression and prostate cancer: A meta-analysis". Biomedical Reports 4.2 (2016): 241-245.
Chicago
Xie, T., Dong, B., Yan, Y., Hu, G., Xu, Y."Association between MMP-2 expression and prostate cancer: A meta-analysis". Biomedical Reports 4, no. 2 (2016): 241-245. https://doi.org/10.3892/br.2015.553
Copy and paste a formatted citation
x
Spandidos Publications style
Xie T, Dong B, Yan Y, Hu G and Xu Y: Association between MMP-2 expression and prostate cancer: A meta-analysis. Biomed Rep 4: 241-245, 2016.
APA
Xie, T., Dong, B., Yan, Y., Hu, G., & Xu, Y. (2016). Association between MMP-2 expression and prostate cancer: A meta-analysis. Biomedical Reports, 4, 241-245. https://doi.org/10.3892/br.2015.553
MLA
Xie, T., Dong, B., Yan, Y., Hu, G., Xu, Y."Association between MMP-2 expression and prostate cancer: A meta-analysis". Biomedical Reports 4.2 (2016): 241-245.
Chicago
Xie, T., Dong, B., Yan, Y., Hu, G., Xu, Y."Association between MMP-2 expression and prostate cancer: A meta-analysis". Biomedical Reports 4, no. 2 (2016): 241-245. https://doi.org/10.3892/br.2015.553
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