LKB1/AMPK pathway mediates resistin‑induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes

  • Authors:
    • Peng Liu
    • Guan‑Chang Cheng
    • Qun‑Hui Ye
    • Yong‑Zhi Deng
    • Lin Wu
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  • Published online on: February 5, 2016     https://doi.org/10.3892/br.2016.593
  • Pages: 387-391
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Abstract

Resistin has been previously demonstrated to induce cardiac hypertrophy, however, the underlying molecular mechanisms of resistin‑induced cardiac hypertrophy remain unclear. Using H9c2 cells, the present study investigated the liver kinase B1 (LKB1)/adenosine monophosphate‑activated protein kinase (AMPK) signaling pathway for a potential role in mediating resistin‑induced cardiomyocyte hypertrophy. Treatment of H9c2 cells with resistin increased cell surface area, protein synthesis, and expression of hypertrophic marker brain natriuretic peptide and β‑myosin heavy chain. Treatment with metformine attenuated these effects of resistin. Furthermore, treatment with resistin decreased phosphorylation of LKB1 and AMPK, whereas pretreatment with metformin increased phosphorylation of LKB1 and AMPK that is reduced by resistin. These results suggest that resistin induces cardiac hypertrophy through the inactivation of the LKB1/AMPK cell signaling pathway.
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March-2016
Volume 4 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Liu P, Cheng GC, Ye QH, Deng YZ and Wu L: LKB1/AMPK pathway mediates resistin‑induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes. Biomed Rep 4: 387-391, 2016
APA
Liu, P., Cheng, G., Ye, Q., Deng, Y., & Wu, L. (2016). LKB1/AMPK pathway mediates resistin‑induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes. Biomedical Reports, 4, 387-391. https://doi.org/10.3892/br.2016.593
MLA
Liu, P., Cheng, G., Ye, Q., Deng, Y., Wu, L."LKB1/AMPK pathway mediates resistin‑induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes". Biomedical Reports 4.3 (2016): 387-391.
Chicago
Liu, P., Cheng, G., Ye, Q., Deng, Y., Wu, L."LKB1/AMPK pathway mediates resistin‑induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes". Biomedical Reports 4, no. 3 (2016): 387-391. https://doi.org/10.3892/br.2016.593