Second trimester maternal serum triple screening marker levels in normal twin and singleton pregnancies

Ren,Feng; Hu,Yu; Zhou,Huan; Zhu,Wen-Ying; Jia,Li; Xu,Jing-Jing; Xue,Jing

doi:10.3892/br.2016.611

April-2016 Volume 4 Issue 4

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April-2016 Volume 4 Issue 4

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Article

Second trimester maternal serum triple screening marker levels in normal twin and singleton pregnancies

Authors:
- Feng Ren
- Yu Hu
- Huan Zhou
- Wen-Ying Zhu
- Li Jia
- Jing-Jing Xu
- Jing Xue
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory, The Affiliated Hospital of Jiangnan University, The Fourth People's Hospital of Wuxi, Wuxi, Jiangsu 214062, P.R. China
Pages: 475-478
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Published online on: February 24, 2016

https://doi.org/10.3892/br.2016.611
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Abstract

The aim of the present study was to evaluate the serum levels of α-fetoprotein (AFP), free-β-human chorionic gonadotropin (free-β-hCG) and unconjugated estriol (uE3) in second trimester maternal serum and comparative analysis of serum markers levels in normal twin and singleton pregnancies, and to evaluate the feasible methods for the screening performances of triple markers in twin pregnancy. The levels of maternal serum markers were measured by magnetic microparticle chemiluminescence immunoassay in the second trimester. TCSoft was used for calculating the risk of Down's syndrome (DS). The marker levels were compared between the twin and singleton pregnancies, along with gestational age, and the weight or age of the pregnant women. The concentrations of the maternal serum markers were higher on average in twin compared to in singleton pregnancies in the second trimester of the gestation. The levels of AFP were 2‑fold higher in twin compared to those in singleton pregnancies in weeks 16, 17 and total gestational weeks. For free‑β‑hCG, the levels were higher in 15 and 18 gestational weeks. However, significant differences were found in all the gestational weeks for uE3. There was no correlation between the levels of markers and weight or age in the twin pregnancies. The serum marker levels of AFP, free‑β‑hCG and uE3 in normal twins were not all 2-fold higher compared to singleton pregnancies. The current singleton gestational age-specific model for DS screening requires further correction so that it is feasible for screening in twin pregnancies.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Second trimester maternal serum triple screening marker levels in normal twin and singleton pregnancies

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