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April-2016 Volume 4 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model

  • Authors:
    • Li‑Juan Qin
    • Yong‑Sen Jia
    • Yi‑Bing Zhang
    • Yin‑Huan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China, Department of Chinese Medicine, College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China
  • Pages: 433-436
    |
    Published online on: February 26, 2016
       https://doi.org/10.3892/br.2016.618
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Abstract

The aim of the present study was to investigate the expression of caveolin-1 in rat brain glioma tissue, and to determine whether interleukin-1β (IL-1β) has a role in this process. Using glioma cells, a tumor‑burdened rat model was established, and the expression of caveolin-1 protein in the tumor sites was significantly increased following intracarotid infusion of IL-1β (3.7 ng/kg/min), as indicated by western blot analysis. The maximum value of the caveolin-1 expression was observed in tumor‑burdened rats after 60 min of IL‑1β perfusion, and which was significantly enhanced by vascular endothelial growth factor (VEGF). In addition, VEGF also significantly increased IL-1β-induced blood tumor barrier (BTB) permeability. The results suggest that the IL-1β-induced BTB permeability increase may be associated with the expression of caveolin-1 protein, and VEGF may be involved in this process.
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Copy and paste a formatted citation
Spandidos Publications style
Qin LJ, Jia YS, Zhang YB and Wang YH: Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model. Biomed Rep 4: 433-436, 2016.
APA
Qin, L., Jia, Y., Zhang, Y., & Wang, Y. (2016). Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model. Biomedical Reports, 4, 433-436. https://doi.org/10.3892/br.2016.618
MLA
Qin, L., Jia, Y., Zhang, Y., Wang, Y."Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model". Biomedical Reports 4.4 (2016): 433-436.
Chicago
Qin, L., Jia, Y., Zhang, Y., Wang, Y."Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model". Biomedical Reports 4, no. 4 (2016): 433-436. https://doi.org/10.3892/br.2016.618
Copy and paste a formatted citation
x
Spandidos Publications style
Qin LJ, Jia YS, Zhang YB and Wang YH: Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model. Biomed Rep 4: 433-436, 2016.
APA
Qin, L., Jia, Y., Zhang, Y., & Wang, Y. (2016). Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model. Biomedical Reports, 4, 433-436. https://doi.org/10.3892/br.2016.618
MLA
Qin, L., Jia, Y., Zhang, Y., Wang, Y."Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model". Biomedical Reports 4.4 (2016): 433-436.
Chicago
Qin, L., Jia, Y., Zhang, Y., Wang, Y."Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model". Biomedical Reports 4, no. 4 (2016): 433-436. https://doi.org/10.3892/br.2016.618
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