Open Access

Nicotinic acetylcholine receptors and cancer (Review)

  • Authors:
    • Ningning Dang
    • Xianguang Meng
    • Haiyan Song
  • View Affiliations

  • Published online on: March 7, 2016     https://doi.org/10.3892/br.2016.625
  • Pages: 515-518
  • Copyright: © Dang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nicotine, the primary addictive constituent of cigarettes, is believed to contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nAChRs), which are membrane ligand‑gated cation channels. nAChRs activation can be triggered by the neurotransmitter Ach, or certain other biological compounds, such as nicotine. In recent years, genome‑wide association studies have indicated that allelic variation in the α5‑α3‑β4 nAChR cluster on chromosome 15q24‑15q25.1 is associated with lung cancer risk. The role of nAChRs in other types of cancer has also been reported. The present review highlights the role of nAChRs in types of human cancer.
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May-2016
Volume 4 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Dang N, Meng X and Song H: Nicotinic acetylcholine receptors and cancer (Review). Biomed Rep 4: 515-518, 2016
APA
Dang, N., Meng, X., & Song, H. (2016). Nicotinic acetylcholine receptors and cancer (Review). Biomedical Reports, 4, 515-518. https://doi.org/10.3892/br.2016.625
MLA
Dang, N., Meng, X., Song, H."Nicotinic acetylcholine receptors and cancer (Review)". Biomedical Reports 4.5 (2016): 515-518.
Chicago
Dang, N., Meng, X., Song, H."Nicotinic acetylcholine receptors and cancer (Review)". Biomedical Reports 4, no. 5 (2016): 515-518. https://doi.org/10.3892/br.2016.625