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Article

Low hemoglobin levels are associated with upper gastrointestinal bleeding

  • Authors:
    • Minoru Tomizawa
    • Fuminobu Shinozaki
    • Rumiko Hasegawa
    • Yoshinori Shirai
    • Yasufumi Motoyoshi
    • Takao Sugiyama
    • Shigenori Yamamoto
    • Naoki Ishige
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Radiology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Surgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Neurology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Neurosurgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan
  • Pages: 349-352
    |
    Published online on: July 27, 2016
       https://doi.org/10.3892/br.2016.727
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Abstract

Upper gastrointestinal (GI) bleeding can be fatal. Blood test variables were reviewed in search of threshold values to detect the presence of occult upper GI bleeding. The records of 1,023 patients who underwent endoscopy at the National Hospital Organization Shimoshizu Hospital from October 2014, to September 2015, were retrospectively reviewed. Of those, 95 had upper GI bleeding. One‑way analysis of variance was applied to blood test variables comparing patients with and without upper GI bleeding. Logistic regression analysis was applied to detect the association of blood test parameters with upper GI bleeding, and receiver‑operator characteristics were applied to establish threshold values. White blood cell count (WBC), platelet (Plt) count, and blood urea nitrogen (BUN) levels were higher, and hemoglobin (Hb) and albumin (Alb) levels were lower in patients with upper GI bleeding. Logistic regression analysis showed that low Hb was significantly associated with upper GI bleeding and a Hb value of 10.8 g/dl was established as the threshold for the diagnosis. In patients with upper GI bleeding, WBC, Plt count, and BUN levels were higher and Hb and Alb levels were reduced. Hb at 10.8 g/dl was established as a threshold value to detect upper GI bleeding.
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1 

Theocharis GJ, Thomopoulos KC, Sakellaropoulos G, Katsakoulis E and Nikolopoulou V: Changing trends in the epidemiology and clinical outcome of acute upper gastrointestinal bleeding in a defined geographical area in Greece. J Clin Gastroenterol. 42:128–133. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Hearnshaw SA, Logan RF, Lowe D, Travis SP, Murphy MF and Palmer KR: Acute upper gastrointestinal bleeding in the UK: Patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut. 60:1327–1335. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Leontiadis GI, Molloy-Bland M, Moayyedi P and Howden CW: Effect of comorbidity on mortality in patients with peptic ulcer bleeding: Systematic review and meta-analysis. Am J Gastroenterol. 108:331–345; quiz 346. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Kim SY, Hyun JJ, Jung SW and Lee SW: Management of non-variceal upper gastrointestinal bleeding. Clin Endosc. 45:220–223. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Wilkins T, Khan N, Nabh A and Schade RR: Diagnosis and management of upper gastrointestinal bleeding. Am Fam Physician. 85:469–476. 2012.PubMed/NCBI

6 

Katano T, Mizoshita T, Senoo K, Sobue S, Takada H, Sakamoto T, Mochiduki H, Ozeki T, Kato A, Matsunami K, et al: The efficacy of transcatheter arterial embolization as the first-choice treatment after failure of endoscopic hemostasis and endoscopic treatment resistance factors. Dig Endosc. 24:364–369. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Walsh RM, Anain P, Geisinger M, Vogt D, Mayes J, Grundfest-Broniatowski S and Henderson JM: Role of angiography and embolization for massive gastroduodenal hemorrhage. J Gastrointest Surg. 3:61–65; discussion 66. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Bozkurt S, Köse A, Arslan ED, Erdoğan S, Üçbilek E, Çevik İ, Ayrık C and Sezgin O: Validity of modified early warning, Glasgow Blatchford, and pre-endoscopic Rockall scores in predicting prognosis of patients presenting to emergency department with upper gastrointestinal bleeding. Scand J Trauma Resusc Emerg Med. 23:1092015. View Article : Google Scholar : PubMed/NCBI

9 

Forrest JA, Finlayson ND and Shearman DJ: Endoscopy in gastrointestinal bleeding. Lancet. 2:394–397. 1974. View Article : Google Scholar : PubMed/NCBI

10 

Hoffmann V, Neubauer H, Heinzler J, Smarczyk A, Hellmich M, Bowe A, Kuetting F, Demir M, Pelc A, Schulte S, et al: A novel easy-to-use prediction scheme for upper gastrointestinal bleeding: Cologne-WATCH (C-WATCH) risk score. Medicine (Baltimore). 94:e16142015. View Article : Google Scholar : PubMed/NCBI

11 

Schutz Y: Protein turnover, ureagenesis and gluconeogenesis. Int J Vitam Nutr Res. 81:101–107. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Adeva MM, Souto G, Blanco N and Donapetry C: Ammonium metabolism in humans. Metabolism. 61:1495–1511. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Mardini H and Record C: Pathogenesis of hepatic encephalopathy: Lessons from nitrogen challenges in man. Metab Brain Dis. 28:201–207. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Häberle J: Clinical and biochemical aspects of primary and secondary hyperammonemic disorders. Arch Biochem Biophys. 536:101–108. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Tomizawa M, Shinozaki F, Hasegawa R, Shirai Y, Motoyoshi Y, Sugiyama T, Yamamoto S and Ishige N: Patient characteristics with high or low blood urea nitrogen in upper gastrointestinal bleeding. World J Gastroenterol. 21:7500–7505. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Tomizawa M, Shinozaki F, Hasegawa R, Shirai Y, Motoyoshi Y, Sugiyama T, Yamamoto S and Ishige N: Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding. World J Gastroenterol. 21:6246–6251. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Lee JL, Oh ES, Lee RW and Finucane TE: Serum albumin and prealbumin in calorically restricted, nondiseased individuals: A systematic review. Am J Med. 128(1023): e1–22. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Tung CF, Chow WK, Chang CS, Peng YC and Hu WH: The prevalence and significance of hypoalbuminemia in non-variceal upper gastrointestinal bleeding. Hepatogastroenterology. 54:1153–1156. 2007.PubMed/NCBI

19 

Gralnek IM, Dumonceau JM, Kuipers EJ, Lanas A, Sanders DS, Kurien M, Rotondano G, Hucl T, Dinis-Ribeiro M, Marmo R, et al: Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 47:a1–a46. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Dahlerup JF, Eivindson M, Jacobsen BA, Jensen NM, Jørgensen SP, Laursen SB, Rasmussen M and Nathan T: Diagnosis and treatment of unexplained anemia with iron deficiency without overt bleeding. Dan Med J. 62:C50722015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tomizawa M, Shinozaki F, Hasegawa R, Shirai Y, Motoyoshi Y, Sugiyama T, Yamamoto S and Ishige N: Low hemoglobin levels are associated with upper gastrointestinal bleeding. Biomed Rep 5: 349-352, 2016.
APA
Tomizawa, M., Shinozaki, F., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T. ... Ishige, N. (2016). Low hemoglobin levels are associated with upper gastrointestinal bleeding. Biomedical Reports, 5, 349-352. https://doi.org/10.3892/br.2016.727
MLA
Tomizawa, M., Shinozaki, F., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Ishige, N."Low hemoglobin levels are associated with upper gastrointestinal bleeding". Biomedical Reports 5.3 (2016): 349-352.
Chicago
Tomizawa, M., Shinozaki, F., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Ishige, N."Low hemoglobin levels are associated with upper gastrointestinal bleeding". Biomedical Reports 5, no. 3 (2016): 349-352. https://doi.org/10.3892/br.2016.727
Copy and paste a formatted citation
x
Spandidos Publications style
Tomizawa M, Shinozaki F, Hasegawa R, Shirai Y, Motoyoshi Y, Sugiyama T, Yamamoto S and Ishige N: Low hemoglobin levels are associated with upper gastrointestinal bleeding. Biomed Rep 5: 349-352, 2016.
APA
Tomizawa, M., Shinozaki, F., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T. ... Ishige, N. (2016). Low hemoglobin levels are associated with upper gastrointestinal bleeding. Biomedical Reports, 5, 349-352. https://doi.org/10.3892/br.2016.727
MLA
Tomizawa, M., Shinozaki, F., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Ishige, N."Low hemoglobin levels are associated with upper gastrointestinal bleeding". Biomedical Reports 5.3 (2016): 349-352.
Chicago
Tomizawa, M., Shinozaki, F., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Ishige, N."Low hemoglobin levels are associated with upper gastrointestinal bleeding". Biomedical Reports 5, no. 3 (2016): 349-352. https://doi.org/10.3892/br.2016.727
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