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Article

Lipopolysaccharide‑binding protein is efficient in biodosimetry during radiotherapy of lung cancer

  • Authors:
    • Justyna Chalubinska‑Fendler
    • Wojciech Fendler
    • Michal Spych
    • Krystyna Wyka
    • Jolanta Luniewska‑Bury
    • Jacek Fijuth
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, Medical University of Łódź, 93‑509 Łódź, Poland, Department of Biostatistics and Translational Medicine, Medical University of Łódź, 91‑738 Łódź, Poland, Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Łódź, 91‑738 Łódź, Poland, Department of Brachytherapy, Regional Oncological Centre, 93‑509 Łódź, Poland
  • Pages: 450-454
    |
    Published online on: August 8, 2016
       https://doi.org/10.3892/br.2016.739
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Abstract

The aim of the present study was to determine if the serum levels of early markers of inflammation, such as interleukin‑6 (IL‑6), tumor necrosis factor‑α (TNF‑α), C‑reactive protein (CRP), and lipopolysaccharide‑binding protein (LBP) were correlated with the radiation dose received by the pulmonary and mediastinal structures of patients with non‑small cell lung cancer (NSCLC). This pilot study included 26 patients with NSCLC who received total radiation doses ranging from 54 to 74 Gy (2.0 Gy/fraction). Cytokines were measured at baseline by enzyme‑linked immunosorbant assay, and following administration of total doses of 20 and 40 Gy. A control group of 26 participants was sampled for comparisons with patient baseline cytokine levels. Only data from the 40‑Gy cytokine blood levels of patients with NSCLC were identified to be correlated with histograms of the parameters of each patient's radiotherapy protocol. The IL‑6, TNF‑α and CRP median baseline levels of the patients with NSCLC were significantly higher than those of the controls (all P≤0.01). No differences were observed between the LBP levels of the patients and controls [median, 36.34 (25‑75%; 31.35‑39.27) vs. 36.92 (30.20‑44.05) µg/ml, respectively; P=0.42]. No significant differences in the levels of the four cytokines between baseline, and at 20 and 40 Gy were observed [IL‑6 (P=0.19); TNF‑α (P=0.68); CRP (P=0.44) and LBP (P=0.29)]. LBP was significantly and positively correlated with the mean radiation dose to the lung (r=0.409; P=0.038), and showed a positive correlation with the percentage of lung volume exposed to at least 20 Gy of the planned radiation dose (r=0.3536; P=0.0764). CRP levels were positively correlated with the mean radiation dose to the esophagus (r=0.404; P=0.041); however, IL‑6, TNF‑α and CRP were not significantly associated with other lung dosimetry parameters. Thus, LBP levels were correlated with radiation exposure of pulmonary tissues, and LBP may be a marker that warrants further investigation on radiotoxicity in NSCLC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Chalubinska‑Fendler J, Fendler W, Spych M, Wyka K, Luniewska‑Bury J and Fijuth J: Lipopolysaccharide‑binding protein is efficient in biodosimetry during radiotherapy of lung cancer. Biomed Rep 5: 450-454, 2016.
APA
Chalubinska‑Fendler, J., Fendler, W., Spych, M., Wyka, K., Luniewska‑Bury, J., & Fijuth, J. (2016). Lipopolysaccharide‑binding protein is efficient in biodosimetry during radiotherapy of lung cancer. Biomedical Reports, 5, 450-454. https://doi.org/10.3892/br.2016.739
MLA
Chalubinska‑Fendler, J., Fendler, W., Spych, M., Wyka, K., Luniewska‑Bury, J., Fijuth, J."Lipopolysaccharide‑binding protein is efficient in biodosimetry during radiotherapy of lung cancer". Biomedical Reports 5.4 (2016): 450-454.
Chicago
Chalubinska‑Fendler, J., Fendler, W., Spych, M., Wyka, K., Luniewska‑Bury, J., Fijuth, J."Lipopolysaccharide‑binding protein is efficient in biodosimetry during radiotherapy of lung cancer". Biomedical Reports 5, no. 4 (2016): 450-454. https://doi.org/10.3892/br.2016.739
Copy and paste a formatted citation
x
Spandidos Publications style
Chalubinska‑Fendler J, Fendler W, Spych M, Wyka K, Luniewska‑Bury J and Fijuth J: Lipopolysaccharide‑binding protein is efficient in biodosimetry during radiotherapy of lung cancer. Biomed Rep 5: 450-454, 2016.
APA
Chalubinska‑Fendler, J., Fendler, W., Spych, M., Wyka, K., Luniewska‑Bury, J., & Fijuth, J. (2016). Lipopolysaccharide‑binding protein is efficient in biodosimetry during radiotherapy of lung cancer. Biomedical Reports, 5, 450-454. https://doi.org/10.3892/br.2016.739
MLA
Chalubinska‑Fendler, J., Fendler, W., Spych, M., Wyka, K., Luniewska‑Bury, J., Fijuth, J."Lipopolysaccharide‑binding protein is efficient in biodosimetry during radiotherapy of lung cancer". Biomedical Reports 5.4 (2016): 450-454.
Chicago
Chalubinska‑Fendler, J., Fendler, W., Spych, M., Wyka, K., Luniewska‑Bury, J., Fijuth, J."Lipopolysaccharide‑binding protein is efficient in biodosimetry during radiotherapy of lung cancer". Biomedical Reports 5, no. 4 (2016): 450-454. https://doi.org/10.3892/br.2016.739
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