Efficacy of daiokanzoto in chronic constipation refractory to first-line laxatives

Hirose,Tatsuya; Shinoda,Yasutaka; Yoshida,Aya; Kurimoto,Machiko; Mori,Kouki; Kawachi,Yuki; Tanaka,Kouji; Takeda,Atsuko; Yoshimura,Tomoaki; Sugiyama,Tadashi

doi:10.3892/br.2016.754

October-2016 Volume 5 Issue 4

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October-2016 Volume 5 Issue 4

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Article

Efficacy of daiokanzoto in chronic constipation refractory to first-line laxatives

Authors:
- Tatsuya Hirose
- Yasutaka Shinoda
- Aya Yoshida
- Machiko Kurimoto
- Kouki Mori
- Yuki Kawachi
- Kouji Tanaka
- Atsuko Takeda
- Tomoaki Yoshimura
- Tadashi Sugiyama
View Affiliations / Copyright

Affiliations: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki‑shi, Gifu 503‑8502, Japan, Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu‑shi, Gifu 501‑1196, Japan
Pages: 497-500
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Published online on: September 8, 2016

https://doi.org/10.3892/br.2016.754
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Abstract

There are only a few treatment options for constipation and limited evidence of suitable treatments.Daiokanzoto (DKT) is a Kampo medicine often used clincally to treat constipation. DKT is a laxative used predominantly in Japan; however, clinical data on its efficacy and safety is lacking. Patients who used DKT, but were intolerant to either magnesium oxide (MgO; MgO group; n=16) or senna extract (Senna group; n=26) were included in the present study. The frequencies of their bowel movements were compared during the 1 week prior to and following DKT administration. Within 24 hours after DKT administration, 93.8% of the patients in the MgO group evacuated their bowels. The median bowel movement frequency 1 week prior to DKT administration was 2.5 and 1 week after DKT administration was significantly increased to 7.5. In the Senna group, within 24 h of DKT administration, 80.8% of the patients evacuated their bowels. The median bowel movement frequency 1 week prior to the DKT treatment was 2.0, which significantly increased to 8.5 1 week after the administration of DKT. The adverse events from DKT treatment were mild and controllable.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Efficacy of daiokanzoto in chronic constipation refractory to first-line laxatives

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