|
1
|
Lu SH, Ohshima H, Fu HM, Tian Y, Li FM,
Blettner M, Wahrendorf J and Bartsch H: Urinary excretion of
N-nitrosamino acids and nitrate by inhabitants of high- and
low-risk areas for esophageal cancer in Northern China: Endogenous
formation of nitrosoproline and its inhibition by vitamin C. Cancer
Res. 46:1485–1491. 1986.PubMed/NCBI
|
|
2
|
Cameron E and Pauling L: Ascorbic acid and
cancer: A review. Proc Natl Acad Sci USA. 75:4538–3542. 1987.
View Article : Google Scholar
|
|
3
|
Creagan ET, Moertel CG, O'Fallon JR,
Schutt AJ, O'Connell MJ, Rubin J and Frytak S: Failure of high-dose
vitamin C (ascorbic acid) therapy to benefit patients with advanced
cancer. A controlled trial. N Engl J Med. 301:687–690. 1979.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Hoffer LJ, Levine M, Assouline S,
Melnychuk D, Padayatty SJ, Rosadiuk K, Rousseau C, Robitaille L and
Miller WH Jr: Phase I clinical trial of i.v. ascorbic acid in
advanced malignancy. Ann Oncol. 19:1969–1974. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Wilson MK, Baguley BC, Wall C, Jameson MB
and Findlay MP: Review of high-dose intravenous vitamin C as an
anticancer agent. Asia Pac J Clin Oncol. 10:22–37. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Hosokawa Y, Monzen S, Yoshino H, Terashima
S, Nakano M, Toshima K, Saga R and Kashiwakura I: Effects of X ray
irradiation in combination with ascorbic acid on tumor control. Mol
Med Rep. 12:5449–5454. 2015.PubMed/NCBI
|
|
7
|
Herst PM, Broadley KW, Harper JL and
McConnell MJ: Pharmacological concentrations of ascorbate
radiosensitize glioblastoma multiforme primary cells by increasing
oxidative DNA damage and inhibiting G2/M arrest. Free Radic Biol
Med. 52:1486–1493. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Shinozaki K, Hosokawa Y, Hazawa M,
Kashiwakura I, Okumura K, Kaku T and Nakayama E: Ascorbic acid
enhances radiation-induced apoptosis in an HL60 human leukemia cell
line. J Radiat Res (Tokyo). 52:229–237. 2011. View Article : Google Scholar
|
|
9
|
Taneja N, Tjalkens R, Philbert MA and
Rehemtulla A: Irradiation of mitochondria initiates apoptosis in a
cell free system. Oncogene. 20:167–177. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Riley PA: Free radicals in biology:
Oxidative stress and the effects of ionizing radiation. Int J
Radiat Biol. 65:27–33. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Matsumoto K, Ueno M, Nakanishi I and Anzai
K: Density of hydroxyl radicals generated in an aqueous solution by
irradiating carbon-ion beam. Chem Pharm Bull (Tokyo). 63:195–199.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Hosokawa Y, Tanaka L, Kaneko M, Sakakura
Y, Tsuruga E, Irie K and Yajima T: Apoptosis induced by generated
OH radicals inside cells after irradiation. Arch Histol Cytol.
65:301–305. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Du J, Cullen JJ and Buettner GR: Ascorbic
acid: Chemistry, biology and the treatment of cancer. Biochim
Biophys Acta. 1826:443–457. 2012.PubMed/NCBI
|
|
14
|
Espey MG, Chen P, Chalmers B, Drisko J,
Sun AY, Levine M and Chen Q: Pharmacologic ascorbate synergizes
with gemcitabine in preclinical models of pancreatic cancer. Free
Radic Biol Med. 50:1610–1619. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Mikirova NA, Casciari JJ, Hunninghake RE
and Riordan NH: Intravenous ascorbic acid protocol for cancer
patients:scientific rationale, pharmacology, and clinical
experience. Funct Foods Health Dis. 3:344–366. 2013.
|
|
16
|
Terashima S, Hosokawa Y, Yoshino H,
Yamaguchi M and Nakamura T: Effect of ascorbic acid and
X-irradiation on HL-60 human leukemia cells: The kinetics of
reactive oxygen species. Oncol Rep. 30:2653–2658. 2013.PubMed/NCBI
|
|
17
|
Sies H and Stahl W: Vitamins E and C,
beta-carotene, and other carotenoids as antioxidants. Am J Clin
Nutr. 62:1315S–1321S. 1995.PubMed/NCBI
|
|
18
|
Sato T, Kinoshita M, Yamamoto T, Ito M,
Nishida T, Takeuchi M, Saitoh D, Seki S and Mukai Y: Treatment of
irradiated mice with high-dose ascorbic acid reduced lethality.
PLoS One. 10:e01170202015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Hosokawa Y, Sakakura Y, Tanaka L, Okumura
K, Yajima T and Kaneko M: Radiation-induced apoptosis is
independent of caspase-8 but dependent on cytochrome c and the
caspase-9 cascade in human leukemia HL60 cells. J Radiat Res
(Tokyo). 46:293–303. 2005. View Article : Google Scholar
|
|
20
|
Mojić M, Bogdanović Pristov J,
Maksimović-Ivanić D, Jones DR, Stanić M, Mijatović S and Spasojević
I: Extracellular iron diminishes anticancer effects of vitamin C:
An in vitro study. Sci Rep. 4:59552014. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Stephenson CM, Levin RD, Spector T and Lis
CG: Phase I clinical trial to evaluate the safety, tolerability,
and pharmacokinetics of high-dose intravenous ascorbic acid in
patients with advanced cancer. Cancer Chemother Pharmacol.
72:139–146. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Monti DA, Mitchell E, Bazzan AJ, Littman
S, Zabrecky G, Yeo CJ, Pillai MV, Newberg AB, Deshmukh S and Levine
M: Phase I evaluation of intravenous ascorbic acid in combination
with gemcitabine and erlotinib in patients with metastatic
pancreatic cancer. PLoS One. 7:e297942012. View Article : Google Scholar : PubMed/NCBI
|
