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Article

Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes

  • Authors:
    • Samira Saravani
    • Davood Yari
    • Ramin Saravani
    • Changiz Azadi Ahmadabadi
  • View Affiliations / Copyright

    Affiliations: Department of Biology, Zabol University, Zabol 98615‑538, Iran, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167‑43463, Iran, Department of Cardiovascular Surgery, Zahedan University of Medical Sciences, Zahedan 98167‑43463, Iran
  • Pages: 329-334
    |
    Published online on: February 9, 2017
       https://doi.org/10.3892/br.2017.856
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Abstract

Type 2 diabetes (T2D) is defined by high levels of glucose in the blood. The collagen IV level is associated with conditions of hyperglycemia and insulin resistance. Collagen type IV α3 chain (COL4A3) is a structural protein of the extracellular matrix (ECM). Matrix metallopeptidase 9 (MMP‑9) is an enzyme that degrades the extracellular matrix and its activity is moderated by TIMP metallopeptidase inhibitor 1 (TIMP‑1). The aim of the current study was to examine the association between genetic polymorphisms of COL4A3 (rs55703767), MMP‑9 (rs17576) and TIMP‑1 (rs6609533) in patients with T2D. This case‑control study was performed on 120 Iranian patients with T2D and 120 healthy individuals. Genotypes were analyzed using the amplification refractory mutation system‑polymerase chain reaction technique. The findings demonstrated significant differences between genotypic and allelic distributions of COL4A3 (G/T) and MMP-9 (A/G) polymorphisms as follows: COL4A3 (G/T); TT vs. GG, odds ratio (OR)=0.235, 95% confidence interval (CI)=0.063‑0.0802 (P=0.013) and T vs. G, OR=0.592, 95% CI=0.371‑0.943 (P=0.026); MMP‑9 (A/G); AG vs. GG, OR=2.429, 95% CI=1.232‑4.820 (P=0.008) and A vs. G, OR=2.176, 95% CI=1.155‑4.130 (P=0.013). No significant association was identified between TIMP-1 (A/G) polymorphism and T2D in females and males. Thus, the genotypic and allelic distributions of COL4A3 (G/T) and MMP‑9 (A/G) polymorphisms were associated with T2D. In addition, no significant association was identified in the genotypic distribution of the TIMP‑1 (A/G) gene in females and in males. Further studies in other ethnic groups are required to confirm these findings.
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1 

Galavi HR, Saravani R, Alamdari AR, Ranjbar N, Damani E and Khodakhier TN: Evaluating the Effect of the rs2229238 and the rs4845625 Interleukin 6 Receptor Gene Polymorphisms on Body Mass Index and the Risk of Type 2 Diabetes in an Iranian Study Population. Int J High Risk Behav Addict. 5:e332892016. View Article : Google Scholar

2 

Matough FA, Budin SB, Hamid ZA, Alwahaibi N and Mohamed J: The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Univ Med J. 12:5–18. 2012. View Article : Google Scholar : PubMed/NCBI

3 

McNaughton D: ‘Diabesity’ down under: Overweight and obesity as cultural signifiers for type 2 diabetes mellitus. Crit Public Health. 23:274–288. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Saravani S, Miri H, Saravani R, Yari D, Nakhaee A and Mahjoubifard M: Association of catalase (rs7943316) and glutathione peroxidase-1 (rs1050450) polymorphisms with the risk of type 2 diabetes (T2DM). Mol Gen Microbiol Virol. 30:216–220. 2015. View Article : Google Scholar

5 

Lakhan SE and Kirchgessner A: The emerging role of dietary fructose in obesity and cognitive decline. Nutr J. 12:1142013. View Article : Google Scholar : PubMed/NCBI

6 

Azmy R, Dawood A, Kilany A, El-Ghobashy Y, Ellakwa AF and El-Daly M: Association analysis of genetic variations of eNOS and α2β1 integrin genes with type 2 diabetic retinopathy. Appl Clin Genet. 5:55–65. 2012.PubMed/NCBI

7 

Saravani R, Esmaeeli E, Tamendani MK and Nejad MN: Oxytocin Receptor Gene Polymorphisms in Patients With Diabetes. Gene, Cell and Tissue. 2:e279042015. View Article : Google Scholar

8 

Tang L, Wang L, Liao Q, Wang Q, Xu L, Bu S, Huang Y, Zhang C, Ye H, Xu X, et al: Genetic associations with diabetes: Meta-analyses of 10 candidate polymorphisms. PLoS One. 8:e703012013. View Article : Google Scholar : PubMed/NCBI

9 

Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S and Scherer PE: Metabolic dysregulation and adipose tissue fibrosis: Role of collagen VI. Mol Cell Biol. 29:1575–1591. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Heidet L, Arrondel C, Forestier L, Cohen-Solal L, Mollet G, Gutierrez B, Stavrou C, Gubler MC and Antignac C: Structure of the human type IV collagen gene COL4A3 and mutations in autosomal Alport syndrome. J Am Soc Nephrol. 12:97–106. 2001.PubMed/NCBI

11 

Saravani R, Hasanian-Langroudi F, Validad MH, Yari D, Bahari G, Faramarzi M, Khateri M and Bahadoram S: Evaluation of possible relationship between COL4A4 gene polymorphisms and risk of keratoconus. Cornea. 34:318–322. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Muona P, Jaakkola S, Zhang RZ, Pan TC, Pelliniemi L, Risteli L, Chu ML, Uitto J and Peltonen J: Hyperglycemic glucose concentrations up-regulate the expression of type VI collagen in vitro. Relevance to alterations of peripheral nerves in diabetes mellitus. Am J Pathol. 142:1586–1597. 1993.PubMed/NCBI

13 

Kim KM, Park SH, Kim JS, Lee WK, Cha SI, Kim CH, Kang YM, Jung TH, Kim IS and Park JY: Polymorphisms in the type IV collagen α3 gene and the risk of COPD. Eur Respir J. 32:35–41. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Štabuc-Šilih M, Ravnik-Glavač M, Glavač D, Hawlina M and Stražišar M: Polymorphisms in COL4A3 and COL4A4 genes associated with keratoconus. Mol Vis. 15:2848–2860. 2009.PubMed/NCBI

15 

Marson BP, Lacchini R, Belo V, Mattos SG, da Costa BP, Poli-de-Figueiredo CE and Tanus-Santos JE: Functional matrix metalloproteinase (MMP)-9 genetic variants modify the effects of hemodialysis on circulating MMP-9 levels. Clin Chim Acta. 414:46–51. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Kowluru RA, Zhong Q and Santos JM: Matrix metalloproteinases in diabetic retinopathy: Potential role of MMP-9. Expert Opin Investig Drugs. 21:797–805. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Wu HD, Bai X, Chen DM, Cao HY and Qin L: Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in the Chinese Han Population: A Case-Control Study. Genet Test Mol Biomarkers. 17:707–712. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Nagase H, Visse R, Murphy G, Cao H-y and Qin L: Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res. 69:562–573. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Rivera S, Tremblay E, Timsit S, Canals O, Ben-Ari Y and Khrestchatisky M: Tissue inhibitor of metalloproteinases-1 (TIMP-1) is differentially induced in neurons and astrocytes after seizures: Evidence for developmental, immediate early gene, and lesion response. J Neurosci. 17:4223–4235. 1997.PubMed/NCBI

20 

Goldbergova MP, Parenica J, Jarkovsky J, Kala P, Poloczek M, Manousek J, Kluz K, Kubkova L, Littnerova S, Tesak M, et al: The association between levels of tissue inhibitor of metalloproteinase-1 with acute heart failure and left ventricular dysfunction in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention. Genet Test Mol Biomarkers. 16:1172–1178. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Brew K and Nagase H: The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity. Biochimica et Biophysica Acta (BBA). Mol Cell Res. 1803:55–71. 2010.

22 

Association AD: American Diabetes Association: Standards of medical care in diabetes. Diabetes Care. 27:(Suppl 1). S15–S35. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Saravani R, Irani Z and Galavi HR: Evaluation of transcription factor 7 like 2 polymorphisms and haplotypes in risk of type 2 diabetes. Rev Rom Med Lab. 24:423–430. 2016.

24 

Saravani R, Galavi HR, Ranjbar N and Alamdari A: ATP-binding cassette transporter A1 polymorphisms and haplotypes in risk of type 2 diabetes. Gene, Cell and Tissue. 4:e436772016. View Article : Google Scholar

25 

Mousavi M, Saravani R, Modrek MJ, Shahrakipour M and Sekandarpour S: Detection of Toxoplasma gondii in Diabetic Patients Using the Nested PCR Assay via RE and B1 Genes. Jundishapur Journal of Microbiology. 9:e294932016. View Article : Google Scholar : PubMed/NCBI

26 

Ghoshal K and Bhattacharyya M: Adiponectin: Probe of the molecular paradigm associating diabetes and obesity. World J Diabetes. 6:151–166. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Tripathi BK and Srivastava AK: Diabetes mellitus: Complications and therapeutics. Med Sci Monit. 12:RA130–RA147. 2006.PubMed/NCBI

28 

Staiger H, Machicao F, Stefan N, Tschritter O, Thamer C, Kantartzis K, Schäfer SA, Kirchhoff K, Fritsche A and Häring HU: Polymorphisms within novel risk loci for type 2 diabetes determine β-cell function. PLoS One. 2:e8322007. View Article : Google Scholar : PubMed/NCBI

29 

Osman OS, Selway JL, Harikumar PE, Stocker CJ, Wargent ET, Cawthorne MA, Jassim S and Langlands K: A novel method to assess collagen architecture in skin. BMC Bioinformatics. 14:2602013. View Article : Google Scholar : PubMed/NCBI

30 

Sternberg M, Grigorova-Borsos AM, Guillot R, Kassab JP, Bakillah A, Urios P, Cohen-Forterre L, Mozère G, André J, Leblond V, et al: Changes in collagen type IV metabolism in diabetes. C R Seances Soc Biol Fil. 187:247–257. 1993.(In French). PubMed/NCBI

31 

Rana K, Tonna S, Wang YY, Sin L, Lin T, Shaw E, Mookerjee I and Savige J: Nine novel COL4A3 and COL4A4 mutations and polymorphisms identified in inherited membrane diseases. Pediatr Nephrol. 22:652–657. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Hou P, Chen Y, Ding J, Li G and Zhang H: A novel mutation of COL4A3 presents a different contribution to Alport syndrome and thin basement membrane nephropathy. Am J Nephrol. 27:538–544. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Ahluwalia TS, Khullar M, Ahuja M, Kohli HS, Bhansali A, Mohan V, Venkatesan R, Rai TS, Sud K and Singal PK: Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians. PLoS One. 4:e51682009. View Article : Google Scholar : PubMed/NCBI

34 

Nazir N, Siddiqui K, Al-Qasim S and Al-Naqeb D: Meta-analysis of diabetic nephropathy associated genetic variants in inflammation and angiogenesis involved in different biochemical pathways. BMC Med Genet. 15:1032014. View Article : Google Scholar : PubMed/NCBI

35 

Pan F, Hua S, Luo Y, Yin D and Ma Z: Genetic susceptibility of early aseptic loosening after total hip arthroplasty: The influence of TIMP-1 gene polymorphism on Chinese Han population. J Orthop Surg. 9:1082014. View Article : Google Scholar

36 

Kumar M, Bhadoria DP, Dutta K, Singh S, Gupta J, Kumar R, Chhillar AK, Yadav V, Singh B and Sharma GL: Combinatorial effect of TIMP-1 and α1AT gene polymorphisms on development of chronic obstructive pulmonary disease. Clin Biochem. 44:1067–1073. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Saravani S, Yari D, Saravani R and Azadi Ahmadabadi C : Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes. Biomed Rep 6: 329-334, 2017.
APA
Saravani, S., Yari, D., Saravani, R., & Azadi Ahmadabadi, C. . (2017). Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes. Biomedical Reports, 6, 329-334. https://doi.org/10.3892/br.2017.856
MLA
Saravani, S., Yari, D., Saravani, R., Azadi Ahmadabadi, C. ."Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes". Biomedical Reports 6.3 (2017): 329-334.
Chicago
Saravani, S., Yari, D., Saravani, R., Azadi Ahmadabadi, C. ."Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes". Biomedical Reports 6, no. 3 (2017): 329-334. https://doi.org/10.3892/br.2017.856
Copy and paste a formatted citation
x
Spandidos Publications style
Saravani S, Yari D, Saravani R and Azadi Ahmadabadi C : Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes. Biomed Rep 6: 329-334, 2017.
APA
Saravani, S., Yari, D., Saravani, R., & Azadi Ahmadabadi, C. . (2017). Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes. Biomedical Reports, 6, 329-334. https://doi.org/10.3892/br.2017.856
MLA
Saravani, S., Yari, D., Saravani, R., Azadi Ahmadabadi, C. ."Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes". Biomedical Reports 6.3 (2017): 329-334.
Chicago
Saravani, S., Yari, D., Saravani, R., Azadi Ahmadabadi, C. ."Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes". Biomedical Reports 6, no. 3 (2017): 329-334. https://doi.org/10.3892/br.2017.856
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