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Article

Identifying the association between interleukin‑6 and lichen planus: A meta‑analysis

  • Authors:
    • Meng Yin
    • Guifeng Li
    • Hui Song
    • Song Lin
  • View Affiliations / Copyright

    Affiliations: School of Dentistry, Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, Shandong 250014, P.R. China, Department of Orthodontics, Nanjing Stomatological Hospital, Nanjing, Jiangsu 210009, P.R. China, Department of Pediatric Dentistry, Jinan Stomatological Hospital, Jinan, Shandong 250002, P.R. China
  • Pages: 571-575
    |
    Published online on: April 7, 2017
       https://doi.org/10.3892/br.2017.887
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Abstract

Numerous studies have examined the association between interleukin‑6 and the pathogenesis of lichen planus (LP)/oral LP (OLP) in various populations; however, there is a lack of systematic analysis. The aim of the present study was to assess this association more precisely, thus a meta‑analysis was performed. Case‑control studies, which were published up to December 2015, were obtained from PubMed, Embase and the China National Knowledge Infrastructure databases. Data were extracted and pooled mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Ultimately, eight studies were included, comprising 299 LP/OLP cases and 231 control subjects. Overall, the pooled MD for IL‑6 was 16.24 (95% CI, 9.84‑22.64; I2=99% for heterogeneity). In the subgroup analysis by ethnicity, a significant increase of the IL‑6 expression level was identified among Asian individuals, but not in Caucasian individuals. Thus, IL‑6 may be significant in the pathogenesis of LP. However, further studies are required to validate these associations.
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Copy and paste a formatted citation
Spandidos Publications style
Yin M, Li G, Song H and Lin S: Identifying the association between interleukin‑6 and lichen planus: A meta‑analysis. Biomed Rep 6: 571-575, 2017.
APA
Yin, M., Li, G., Song, H., & Lin, S. (2017). Identifying the association between interleukin‑6 and lichen planus: A meta‑analysis. Biomedical Reports, 6, 571-575. https://doi.org/10.3892/br.2017.887
MLA
Yin, M., Li, G., Song, H., Lin, S."Identifying the association between interleukin‑6 and lichen planus: A meta‑analysis". Biomedical Reports 6.5 (2017): 571-575.
Chicago
Yin, M., Li, G., Song, H., Lin, S."Identifying the association between interleukin‑6 and lichen planus: A meta‑analysis". Biomedical Reports 6, no. 5 (2017): 571-575. https://doi.org/10.3892/br.2017.887
Copy and paste a formatted citation
x
Spandidos Publications style
Yin M, Li G, Song H and Lin S: Identifying the association between interleukin‑6 and lichen planus: A meta‑analysis. Biomed Rep 6: 571-575, 2017.
APA
Yin, M., Li, G., Song, H., & Lin, S. (2017). Identifying the association between interleukin‑6 and lichen planus: A meta‑analysis. Biomedical Reports, 6, 571-575. https://doi.org/10.3892/br.2017.887
MLA
Yin, M., Li, G., Song, H., Lin, S."Identifying the association between interleukin‑6 and lichen planus: A meta‑analysis". Biomedical Reports 6.5 (2017): 571-575.
Chicago
Yin, M., Li, G., Song, H., Lin, S."Identifying the association between interleukin‑6 and lichen planus: A meta‑analysis". Biomedical Reports 6, no. 5 (2017): 571-575. https://doi.org/10.3892/br.2017.887
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