Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production

  • Authors:
    • Sang Mi Woo
    • Sang‑Chul Kwon
    • Seong Gyu Ko
    • Sung‑Gook Cho
  • View Affiliations

  • Published online on: May 3, 2017     https://doi.org/10.3892/br.2017.897
  • Pages: 681-685
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Abstract

Cancer remains a leading cause of mortality worldwide, therefore food products are being investigated for potential prevention or treatment strategies. The ingredient, barley grass extract (Hordeum vulgare L.; Bex) is used to prevent or ameliorate various types of disease. In cancer, Bex has been revealed to inhibit tumor growth. However, its effect on cancer cells is yet to be clearly defined. In the present study, the effect of Bex on cancer cell growth was investigated. Bex inhibited the viabilities of breast and prostate cancer cells according to the results of MTT assays. Accordingly, Bex caused apoptosis, which was confirmed by Annexin V staining and western blot analysis for poly (ADP‑ribose) polymerase and caspases. Furthermore, Bex increased the intracellular levels of reactive oxygen species (ROS), and N‑acetyl‑L‑cystein blocked Bex‑induced apoptosis. Therefore, the study demonstrated that Bex causes apoptosis of breast and prostate cancer cells by increasing intracellular ROS levels.
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June-2017
Volume 6 Issue 6

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Spandidos Publications style
Woo SM, Kwon SC, Ko SG and Cho SG: Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production. Biomed Rep 6: 681-685, 2017
APA
Woo, S.M., Kwon, S., Ko, S.G., & Cho, S. (2017). Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production. Biomedical Reports, 6, 681-685. https://doi.org/10.3892/br.2017.897
MLA
Woo, S. M., Kwon, S., Ko, S. G., Cho, S."Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production". Biomedical Reports 6.6 (2017): 681-685.
Chicago
Woo, S. M., Kwon, S., Ko, S. G., Cho, S."Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production". Biomedical Reports 6, no. 6 (2017): 681-685. https://doi.org/10.3892/br.2017.897