Open Access

Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers

  • Authors:
    • Iván Delgado-Enciso
    • Violeta M. Madrigal-Perez
    • Agustin Lara-Esqueda
    • Martha G. Diaz-Sanchez
    • Jose Guzman-Esquivel
    • Luis E. Rosas-Vizcaino
    • Oscar O. Virgen-Jimenez
    • Juleny Kleiman-Trujillo
    • Maria R. Lagarda-Canales
    • Gabriel Ceja-Espiritu
    • Viridiana Rangel-Salgado
    • Uriel A. Lopez-Lemus
    • Josuel Delgado-Enciso
    • Agustin   D. Lara-Basulto
    • Alejandro D. Soriano Hernández
  • View Affiliations

  • Published online on: January 2, 2018     https://doi.org/10.3892/br.2018.1038
  • Pages:156-159
  • Copyright: © Delgado-Enciso et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: HTML 0 views | PDF 0 views     Cited By: 0 citations

Abstract

Potassium permanganate has been reported to be an effective treatment for certain types of wounds. The aim of the present study was to evaluate the use of potassium permanganate in the treatment of diabetic foot ulcers. A single-blind, randomized, controlled clinical trial was conducted on patients with type 2 diabetes mellitus that presented with a foot ulcer persisting for >3 months. The control group (n=10) was treated with the current standard treatment, which comprises of measures for reducing pressure in the ulcerated area, daily cleansing of the ulcer with potable water and antiseptic wash solution, and the application of a disinfectant solution on the entire surface area of the ulcer; while the intervention group (n=15) received the standard treatment plus 5% topical potassium permanganate solution applied once a day for 21 days. In the intervention group, 1 patient did not tolerate the treatment and was eliminated from the study on the first day. The remaining patients tolerated the interventions well. At the end of the treatment period, ulcers in the control group had decreased by 38% whereas those in the intervention group decreased by 73% (P<0.009). The degree of decrease was also investigated; the ulcer size was ≥50% decreased in 40% of patients in the control group and in 86% of patients in the intervention group (P=0.02). In conclusion, the results of the present study indicate that topical potassium permanganate is well tolerated and significantly accelerates the healing process of diabetic foot ulcers.

Related Articles

Journal Cover

February 2018
Volume 8 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Delgado-Enciso, I., Madrigal-Perez, V.M., Lara-Esqueda, A., Diaz-Sanchez, M.G., Guzman-Esquivel, J., Rosas-Vizcaino, L.E. ... Soriano Hernández, A.D. (2018). Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers. Biomedical Reports, 8, 156-159. https://doi.org/10.3892/br.2018.1038
MLA
Delgado-Enciso, I., Madrigal-Perez, V. M., Lara-Esqueda, A., Diaz-Sanchez, M. G., Guzman-Esquivel, J., Rosas-Vizcaino, L. E., Virgen-Jimenez, O. O., Kleiman-Trujillo, J., Lagarda-Canales, M. R., Ceja-Espiritu, G., Rangel-Salgado, V., Lopez-Lemus, U. A., Delgado-Enciso, J., Lara-Basulto, A. D., Soriano Hernández, A. D."Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers". Biomedical Reports 8.2 (2018): 156-159.
Chicago
Delgado-Enciso, I., Madrigal-Perez, V. M., Lara-Esqueda, A., Diaz-Sanchez, M. G., Guzman-Esquivel, J., Rosas-Vizcaino, L. E., Virgen-Jimenez, O. O., Kleiman-Trujillo, J., Lagarda-Canales, M. R., Ceja-Espiritu, G., Rangel-Salgado, V., Lopez-Lemus, U. A., Delgado-Enciso, J., Lara-Basulto, A. D., Soriano Hernández, A. D."Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers". Biomedical Reports 8, no. 2 (2018): 156-159. https://doi.org/10.3892/br.2018.1038