Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers

Delgado-Enciso,Iván; Madrigal-Perez,Violeta  M.; Lara-Esqueda,Agustin; Diaz-Sanchez,Martha   G.; Guzman-Esquivel,Jose; Rosas-Vizcaino,Luis   E.; Virgen-Jimenez,Oscar   O.; Kleiman-Trujillo,Juleny; Lagarda-Canales,Maria  R.; Ceja-Espiritu,Gabriel; Rangel-Salgado,Viridiana; Lopez-Lemus,Uriel   A.; Delgado-Enciso,Josuel; Lara-Basulto,Agustin   D.; Soriano Hernández,Alejandro   D.

doi:10.3892/br.2018.1038

February-2018 Volume 8 Issue 2

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February-2018 Volume 8 Issue 2

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Article Open Access

Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers

Authors:
- Iván Delgado-Enciso
- Violeta M. Madrigal-Perez
- Agustin Lara-Esqueda
- Martha G. Diaz-Sanchez
- Jose Guzman-Esquivel
- Luis E. Rosas-Vizcaino
- Oscar O. Virgen-Jimenez
- Juleny Kleiman-Trujillo
- Maria R. Lagarda-Canales
- Gabriel Ceja-Espiritu
- Viridiana Rangel-Salgado
- Uriel A. Lopez-Lemus
- Josuel Delgado-Enciso
- Agustin D. Lara-Basulto
- Alejandro D. Soriano Hernández
View Affiliations / Copyright

Affiliations: Department of Research, Cancerology State Institute, Colima State Health Services, Colima 28085, Mexico, Department of Public Health, School of Medicine, University of Colima, Las Víboras, Colima 28040, Mexico, Department of Research, Foundation for Cancer Ethics, Education and Research of the Cancerology State Institute, Colima 28085, Mexico

Copyright: © Delgado-Enciso et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 156-159
|
Published online on: January 2, 2018

https://doi.org/10.3892/br.2018.1038
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Abstract

Potassium permanganate has been reported to be an effective treatment for certain types of wounds. The aim of the present study was to evaluate the use of potassium permanganate in the treatment of diabetic foot ulcers. A single-blind, randomized, controlled clinical trial was conducted on patients with type 2 diabetes mellitus that presented with a foot ulcer persisting for >3 months. The control group (n=10) was treated with the current standard treatment, which comprises of measures for reducing pressure in the ulcerated area, daily cleansing of the ulcer with potable water and antiseptic wash solution, and the application of a disinfectant solution on the entire surface area of the ulcer; while the intervention group (n=15) received the standard treatment plus 5% topical potassium permanganate solution applied once a day for 21 days. In the intervention group, 1 patient did not tolerate the treatment and was eliminated from the study on the first day. The remaining patients tolerated the interventions well. At the end of the treatment period, ulcers in the control group had decreased by 38% whereas those in the intervention group decreased by 73% (P<0.009). The degree of decrease was also investigated; the ulcer size was ≥50% decreased in 40% of patients in the control group and in 86% of patients in the intervention group (P=0.02). In conclusion, the results of the present study indicate that topical potassium permanganate is well tolerated and significantly accelerates the healing process of diabetic foot ulcers.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers

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Abstract

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