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Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis

  • Authors:
    • Rui Wang
    • Jun Shen
    • Rui Yang
    • Wan-Guo Wang
    • Ye Yuan
    • Zhong-Hua Guo
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Cardiology, Renmin Hospital, Hubei University of Medicine Shiyan, Hubei 442000, P.R. China, Department of Orthopedics, People's Hospital of Dongxihu District, Wuhan, Hubei 430040, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 241-248
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    Published online on: January 25, 2018
       https://doi.org/10.3892/br.2018.1048
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Abstract

Numerous studies have focused on the association between heme oxygenase-1 (HO-1) gene promoter polymorphisms and susceptibility to cancer; however, results remain ambiguous. The present systematic Human Genome Epidemiology review and meta-analysis aimed to clarify this association. A systematic search was used to assess the association of HO-1 gene polymorphisms with cancer susceptibility in the PubMed, Web of Science, Cochrane Library, Wanfang Data and China National Knowledge Infrastructure databases, with all reviewed studies published before April 10, 2017. Review Manager 5.3 and Stata 12.0 software were used to perform the meta-analysis. A total of 14 studies were included in the analysis. Overall, no significant associations of the HO-1 (GT)n and T(-413)A polymorphisms with cancer susceptibility were identified. However, subgroup analyses by ethnicity and cancer type indicated that the LL and L-allele (LL+LS) genotypes of HO-1 (GT)n were associated with increased susceptibility to cancer compared with the SS+SL and SS genotypes in the following subgroups: East Asian [LL+LS vs. SS: odds ratio (OR)=1.51, 95% confidence interval (CI)=1.11-2.05, P=0.0003; LL vs. SS+SL: OR=1.44, 95% CI=1.04-2.01, P=0.03; LL vs. SS: OR=1.64, 95% CI=1.07-2.52, P=0.02]; squamous cell carcinoma (LL+LS vs. SS: OR=1.78, 95% CI=1.35-2.34, P<0.05; LL vs. SS+SL: OR=1.71, 95% CI=1.34-2.18, P<0.05; LL vs. SS: OR=2.26, 95% CI =1.62-3.14, P<0.05); and digestive tract cancer + East Asian (LL+LS vs. SS: OR=1.56, 95% CI=1.22-1.98, P<0.05; LL vs. SS: OR=1.80, 95% CI=1.06-3.05, P<0.05). These findings indicated that there was no association of the HO-1 (GT)n and T(-413)A polymorphisms with cancer susceptibility, while the L-allele genotypes (LL and LS) of HO-1 (GT)n may be susceptibility factors for cancer in East Asian, digestive tract cancer in East Asian and squamous cell carcinoma populations. Due to limitations of the reviewed studies, additional large-scale and refined studies are now required to confirm the present findings.
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Spandidos Publications style
Wang R, Shen J, Yang R, Wang W, Yuan Y and Guo Z: Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis. Biomed Rep 8: 241-248, 2018.
APA
Wang, R., Shen, J., Yang, R., Wang, W., Yuan, Y., & Guo, Z. (2018). Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis. Biomedical Reports, 8, 241-248. https://doi.org/10.3892/br.2018.1048
MLA
Wang, R., Shen, J., Yang, R., Wang, W., Yuan, Y., Guo, Z."Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis". Biomedical Reports 8.3 (2018): 241-248.
Chicago
Wang, R., Shen, J., Yang, R., Wang, W., Yuan, Y., Guo, Z."Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis". Biomedical Reports 8, no. 3 (2018): 241-248. https://doi.org/10.3892/br.2018.1048
Copy and paste a formatted citation
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Spandidos Publications style
Wang R, Shen J, Yang R, Wang W, Yuan Y and Guo Z: Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis. Biomed Rep 8: 241-248, 2018.
APA
Wang, R., Shen, J., Yang, R., Wang, W., Yuan, Y., & Guo, Z. (2018). Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis. Biomedical Reports, 8, 241-248. https://doi.org/10.3892/br.2018.1048
MLA
Wang, R., Shen, J., Yang, R., Wang, W., Yuan, Y., Guo, Z."Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis". Biomedical Reports 8.3 (2018): 241-248.
Chicago
Wang, R., Shen, J., Yang, R., Wang, W., Yuan, Y., Guo, Z."Association between heme oxygenase-1 gene promoter polymorphisms and cancer susceptibility: A meta-analysis". Biomedical Reports 8, no. 3 (2018): 241-248. https://doi.org/10.3892/br.2018.1048
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