Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
August-2018 Volume 9 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2018 Volume 9 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Second‑line triple therapy in failures with vonoprazan‑based triple therapy for eradication of Helicobacter pylori

  • Authors:
    • Naoyoshi Mori
    • Yuuki Nishiura
    • Daisuke Suga
    • Isao Moritani
    • Yutaka Yamanaka
    • Yumi Ooya
    • Hidekazu Inoue
    • Koujirou Takase
    • Masato Hioki
    • Katsuya Shiraki
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Mie Prefectural General Medical Center, Yokkaichi, Mie 510‑8561, Japan, Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510‑8561, Japan
  • Pages: 169-174
    |
    Published online on: June 11, 2018
       https://doi.org/10.3892/br.2018.1111
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastric acid inhibition during treatment is important for the eradication of Helicobacter pylori (H. pylori) infection. A novel potassium‑competitive acid blocker, vonoprazan (VPZ), has been demonstrated to achieve high eradication rates; however, the efficacy of second‑line treatment in failures of VPZ‑based triple therapy has not been well studied. The aim of the current study was to determine the efficacy of VPZ in a first‑line regimen for H. pylori eradication, and the efficacy of a second‑line regimen using metronidazole (MTZ) in failures with the first‑line regimen. Of 580 subjects enrolled in the study, 524 patients completed first‑line treatment (275 patients who received VPZ and 249 patients who received LPZ). First‑line regimens consisted of a combination of clarithromycin (CAM) 200 or 400 mg twice a day, amoxicillin (AMPC) 750 mg twice a day, and either LPZ 30 mg or VPZ 20 mg twice a day, administered orally for 7 days. CAM and VPZ/LPZ were replaced with metronidazole (MTZ) 250 mg and rabeprazole 10 mg in the second‑line regimens. The eradication of H. pylori was assessed by the H. pylori stool antigen test. The overall first‑line eradication rate with VPZ was significantly higher than that with LPZ [91.0% (250/275) vs. 84.7% (211/249), respectively, P=0.030]. The dose of CAM (400 vs. 800 mg) did not affect the eradication rate in either the VPZ or LPZ regimens. The overall eradication rates of the second‑line regimens with MTZ did not differ significantly between the VPZ‑failure and LPZ‑failure groups [87.0% (20/23) vs. 87.9% (29/33), respectively, P=0.700]. Therefore, VPZ was significantly more effective than LPZ for first‑line treatment. In patients with failure of first‑line eradication therapy, successful results of second‑line eradication therapy did not differ between the VPZ‑ and LPZ‑failure groups. In conclusion, VPZ‑based triple therapy should be recommended for eradication of H. pylori.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Murakami K, Sakurai Y, Shiino M, Funao N, Nishimura A and Asaka M: Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: A phase III, randomised, double-blind study. Gut. 65:1439–1446. 2016. View Article : Google Scholar : PubMed/NCBI

2 

McColl KE: Clinical practice. Helicobacter pylori infection. N Engl J Med. 362:1597–1604. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Tsujimae M, Yamashita H, Hashimura H, Kano C, Shimoyama K, Kanamori A, Matsumoto K, Koizumi A, Momose K, Eguchi T, et al: A comparative study of a new class of gastric acid suppressant agent named vonoprazan versus esomeprazole for the eradication of Helicobacter pylori. Digestion. 94:240–246. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Okamura T, Suga T, Nagaya T, Arakura N, Matsumoto T, Nakayama Y and Tanaka E: Antimicrobial resistance and characteristics of eradication therapy of Helicobacter pylori in Japan: A multi-generational comparison. Helicobacter. 19:214–220. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Graham DY and Shiotani A: New concepts of resistance in the treatment of Helicobacter pylori infections. Nat Clin Pract Gastroenterol Hepatol. 5:321–331. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Hunt RH: pH and Hp-gastric acid secretion and Helicobacter pylori: Implications for ulcer healing and eradication of the organism. Am J Gastroenterol. 88:481–483. 1993.PubMed/NCBI

7 

Sakurai Y, Shiino M, Okamoto H, Nishimura A, Nakamura K and Hasegawa S: Pharmacokinetics and safety of triple therapy with vonoprazan, amoxicillin, and clarithromycin or metronidazole: A phase 1, open-label, randomized, crossover study. Adv Ther. 33:1519–1535. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Jung YS, Kim EH and Park CH: Systematic review with meta-analysis: The efficacy of vonoprazan-based triple therapy on Helicobacter pylori eradication. Aliment Pharmacol Ther. 46:106–114. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Tanabe H, Ando K, Sato K, Ito T, Goto M, Sato T, Fujinaga A, Kawamoto T, Utsumi T, Yanagawa N, et al: Efficacy of vonoprazan-based triple therapy for Helicobacter pylori eradication: A multicenter study and a review of the literature. Dig Dis Sci. 64:3069–3076. 2017. View Article : Google Scholar

10 

International Conference on Harmonisation of Technical Requirements for Pharmaceuticals for Human Use: ICH Harmonised Tripartite Guideline: Guideline for good clinical Practice E6 (R1). https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E6/E6_R1_Guideline.pdf

11 

National Cancer Institute, National Institutes of Health, US Department of Health and Human Services: Common Terminology criteria for adverse events (CTCAE). Version 4.0.

12 

Grayson ML, Eliopoulos GM, Ferraro MJ and Moellering RC Jr: Effect of varying pH on the susceptibility of Campylobacter pylori to antimicrobial agents. Eur J Clin Microbiol Infect Dis. 8:888–889. 1989. View Article : Google Scholar : PubMed/NCBI

13 

Sachs G, Meyer-Rosberg K, Scott DR and Melchers K: Acid, protons and Helicobacter pylori. Yale J Biol Med. 69:301–316. 1996.PubMed/NCBI

14 

Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O and Sachs G: Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438). J Pharmacol Exp Ther. 339:412–420. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M and Inatomi N: 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther. 335:231–238. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Matsukawa J, Hori Y, Nishida H, Kajino M and Inatomi N: A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands. Biochem Pharmacol. 81:1145–1151. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M and Inatomi N: A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther. 337:797–804. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Sakurai Y, Mori Y, Okamoto H, Nishimura A, Komura E, Araki T and Shiramoto M: Acid-inhibitory effects of vonoprazan 20 mg compared with esomeprazole 20 mg or rabeprazole 10 mg in healthy adult male subjects-a randomised open-label cross-over study. Aliment Pharmacol Ther. 42:719–730. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Ashida K, Sakurai Y, Nishimura A, Kudou K, Hiramatsu N, Umegaki E, Iwakiri K and Chiba T: Randomised clinical trial: A dose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis. Aliment Pharmacol Ther. 42:685–695. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Ashida K, Sakurai Y, Hori T, Kudou K, Nishimura A, Hiramatsu N, Umegaki E and Iwakiri K: Randomised clinical trial: Vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the healing of erosive oesophagitis. Aliment Pharmacol Ther. 43:240–251. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Miwa H, Uedo N, Watari J, Mori Y, Sakurai Y, Takanami Y, Nishimura A, Tatsumi T and Sakaki N: Randomised clinical trial: Efficacy and safety of vonoprazan vs. lansoprazole in patients with gastric or duodenal ulcers - results from two phase 3, non-inferiority randomised controlled trials. Aliment Pharmacol Ther. 45:240–252. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Kagawa T, Iwamuro M, Ishikawa S, Ishida M, Kuraoka S, Sasaki K, Sakakihara I, Izumikawa K, Yamamoto K, Takahashi S, et al: Vonoprazan prevents bleeding from endoscopic submucosal dissection-induced gastric ulcers. Aliment Pharmacol Ther. 44:583–591. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Ishimura N, Owada Y, Aimi M, Oshima T, Kamada T, Inoue K, Mikami H, Takeuchi T, Miwa H, Higuchi K, et al: No increase in gastric acid secretion in healthy Japanese over the past two decades. J Gastroenterol. 50:844–852. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Ishioka H, Mizuno M, Take S, Ishiki K, Nagahara Y, Yoshida T, Okada H, Yokota K and Oguma K: A better cure rate with 800 mg than with 400 mg clarithromycin regimens in one-week triple therapy for Helicobacter pylori infection in cigarette-smoking peptic ulcer patients. Digestion. 75:63–68. 2007. View Article : Google Scholar : PubMed/NCBI

25 

De Francesco V, Margiotta M, Zullo A, Hassan C, Troiani L, Burattini O, Stella F, Di Leo A, Russo F, Marangi S, et al: Clarithromycin-resistant genotypes and eradication of Helicobacter pylori. Ann Intern Med. 144:94–100. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Kato M, Yamaoka Y, Kim JJ, Reddy R, Asaka M, Kashima K, Osato MS, El-Zaatari FA, Graham DY and Kwon DH: Regional differences in metronidazole resistance and increasing clarithromycin resistance among Helicobacter pylori isolates from Japan. Antimicrob Agents Chemother. 44:2214–2216. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Katayama Y, Toyoda K, Kusano Y, Suda T, Adachi S, Terauchi I, Oka S, Takahashi M and Tamano M: Efficacy of vonoprazan-based second-line Helicobacter pylori eradication therapy in patients for whom vonoprazan-based first-line treatment failed. Gut. 66:752–753. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Sakurai K, Suda H, Ido Y, Takeichi T, Okuda A, Hasuda K and Hattori M: Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy. World J Gastroenterol. 23:668–675. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mori N, Nishiura Y, Suga D, Moritani I, Yamanaka Y, Ooya Y, Inoue H, Takase K, Hioki M, Shiraki K, Shiraki K, et al: Second‑line triple therapy in failures with vonoprazan‑based triple therapy for eradication of Helicobacter pylori. Biomed Rep 9: 169-174, 2018.
APA
Mori, N., Nishiura, Y., Suga, D., Moritani, I., Yamanaka, Y., Ooya, Y. ... Shiraki, K. (2018). Second‑line triple therapy in failures with vonoprazan‑based triple therapy for eradication of Helicobacter pylori. Biomedical Reports, 9, 169-174. https://doi.org/10.3892/br.2018.1111
MLA
Mori, N., Nishiura, Y., Suga, D., Moritani, I., Yamanaka, Y., Ooya, Y., Inoue, H., Takase, K., Hioki, M., Shiraki, K."Second‑line triple therapy in failures with vonoprazan‑based triple therapy for eradication of Helicobacter pylori". Biomedical Reports 9.2 (2018): 169-174.
Chicago
Mori, N., Nishiura, Y., Suga, D., Moritani, I., Yamanaka, Y., Ooya, Y., Inoue, H., Takase, K., Hioki, M., Shiraki, K."Second‑line triple therapy in failures with vonoprazan‑based triple therapy for eradication of Helicobacter pylori". Biomedical Reports 9, no. 2 (2018): 169-174. https://doi.org/10.3892/br.2018.1111
Copy and paste a formatted citation
x
Spandidos Publications style
Mori N, Nishiura Y, Suga D, Moritani I, Yamanaka Y, Ooya Y, Inoue H, Takase K, Hioki M, Shiraki K, Shiraki K, et al: Second‑line triple therapy in failures with vonoprazan‑based triple therapy for eradication of Helicobacter pylori. Biomed Rep 9: 169-174, 2018.
APA
Mori, N., Nishiura, Y., Suga, D., Moritani, I., Yamanaka, Y., Ooya, Y. ... Shiraki, K. (2018). Second‑line triple therapy in failures with vonoprazan‑based triple therapy for eradication of Helicobacter pylori. Biomedical Reports, 9, 169-174. https://doi.org/10.3892/br.2018.1111
MLA
Mori, N., Nishiura, Y., Suga, D., Moritani, I., Yamanaka, Y., Ooya, Y., Inoue, H., Takase, K., Hioki, M., Shiraki, K."Second‑line triple therapy in failures with vonoprazan‑based triple therapy for eradication of Helicobacter pylori". Biomedical Reports 9.2 (2018): 169-174.
Chicago
Mori, N., Nishiura, Y., Suga, D., Moritani, I., Yamanaka, Y., Ooya, Y., Inoue, H., Takase, K., Hioki, M., Shiraki, K."Second‑line triple therapy in failures with vonoprazan‑based triple therapy for eradication of Helicobacter pylori". Biomedical Reports 9, no. 2 (2018): 169-174. https://doi.org/10.3892/br.2018.1111
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team