Overall survival of classical Hodgkin's lymphoma in Saudi patients is affected by XPG repair gene polymorphism

Al Sayed Ahmed,Huda; Raslan,Wasim  Fawzi; Deifalla,Abdel  Halim Salem; Fathallah,Mohammad   Dahmani

doi:10.3892/br.2018.1165

January-2019 Volume 10 Issue 1

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January-2019 Volume 10 Issue 1

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Article

Overall survival of classical Hodgkin's lymphoma in Saudi patients is affected by XPG repair gene polymorphism

Authors:
- Huda Al Sayed Ahmed
- Wasim Fawzi Raslan
- Abdel Halim Salem Deifalla
- Mohammad Dahmani Fathallah
View Affiliations / Copyright

Affiliations: Pathology Services Division and Laboratory Department, Johns Hopkins Aramco Healthcare, Dhahran 34465, Kingdom of Saudi Arabia, Department of Anatomy, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 26671, Kingdom of Bahrain, Department of Higher Studies, Arabian Gulf University, Manama 26671, Kingdom of Bahrain
Pages: 10-16
|
Published online on: October 30, 2018

https://doi.org/10.3892/br.2018.1165
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Abstract

In Hodgkin's lymphoma (HL), single nucleotide polymorphisms (SNPs) of specific DNA repair genes have been identified to have an important role in the risk of HL. Consequently, they may also serve an important role in HL prognosis and disease outcome. The present study aimed to define an SNP molecular profile, based on DNA repair genes mutations, as predictive biomarkers for the prognostic outcome of patients with Classical HL (CHL) in Saudi Arabia. Genotyping of selected SNPs located in selected DNA repair genes was performed on 100 CHL cases and an equivalent number of healthy controls. No significant associations between CHL disease relapse (DR) or overall survival (OS) and 4 DNA repair genes were observed, with the exception of xeroderma pigmentosum, complementation group G (XPG) repair gene SNP (rs17655), which revealed a statistically significant association with CHL patient survival (P=0.036). Accordingly, these data suggest that the XPG gene may be a useful predictive molecular genetic biomarker for CHL clinical outcome. The present study also provided valuable insights on the contribution of DNA repair genes in Saudi patients with CHL. To the best of our knowledge, we defined for the first time, a specific genetic pattern associated with CHL outcome was defined in the present study in Saudi patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Overall survival of classical Hodgkin's lymphoma in Saudi patients is affected by XPG repair gene polymorphism

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