Circulating angiopoietin‑like protein 2 levels are associated with decreased renal function in HIV+ subjects on cART: A potential marker of kidney disease

Pinzone,Marilia  Rita; Ceccarelli,Manuela; Venanzi Rullo,Emmanuele; Maresca,Mauro; Bruno,Roberto; Condorelli,Fabrizio; Di Rosa,Michele; Madeddu,Giordano; Focà,Emanuele; Calcagno,Andrea; Celesia,Benedetto  Maurizio; Cacopardo,Bruno; Nunnari,Giuseppe; Pellicanò,Giovanni  F.

doi:10.3892/br.2019.1183

Circulating angiopoietin‑like protein 2 levels are associated with decreased renal function in HIV+ subjects on cART: A potential marker of kidney disease

Authors:
- Marilia Rita Pinzone
- Manuela Ceccarelli
- Emmanuele Venanzi Rullo
- Mauro Maresca
- Roberto Bruno
- Fabrizio Condorelli
- Michele Di Rosa
- Giordano Madeddu
- Emanuele Focà
- Andrea Calcagno
- Benedetto Maurizio Celesia
- Bruno Cacopardo
- Giuseppe Nunnari
- Giovanni F. Pellicanò
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Affiliations: Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Catania, I‑95123 Catania, Italy, Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, I‑98124 Messina, Italy, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA, Department of Pharmacological Sciences, University of Eastern Piedmont ‘A. Avogadro’, I‑13100 Novara, Italy, Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, University of Catania, I‑95123 Catania, Italy, Department of Medical, Surgical and Experimental Sciences, Division of Infectious Diseases, University of Sassari, I‑07100 Sassari, Italy, Department of Clinical and Experimental Sciences, Division of Infectious Diseases, University of Brescia, I‑25121 Brescia, Italy, Department of Medical Sciences, Unit of Infectious Diseases, University of Torino, I‑10124 Torino, Italy, Department of Human Pathology in Adult and Developmental Age ‘G. Barresi’, University of Messina, I‑98124 Messina, Italy
Published online on: January 7, 2019 https://doi.org/10.3892/br.2019.1183
Pages: 140-144

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Abstract

Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV‑infected individuals, even in the antiretroviral therapy (ART) era. Inflammatory cytokines and adipokines have been suggested to play a role in the development of CKD. The aim of the present study was to examine the circulating levels of a novel proinflammatory cytokine, angiopoietin‑like protein 2 (ANGPTL2), in a cohort of 72 HIV‑positive subjects on ART. HIV‑positive patients were on cART for at least one year. Urine and blood samples were collected. Various factors were analyzed including body mass index (BMI), smoking, and presence/treatment for comorbidities such as diabetes. The estimated glomerular filtration rate was calculated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD‑EPI) equation. Plasma samples obtained were stored and used to measure sCD14 and ANGPTL2 levels. Data were presented as mean (± standard deviation) or median (interquartile range) for continuous variables. Categorical variables were expressed as number (%). Variables were compared using Student's t-test, Mann‑Whitney test, or χ2 test. The results showed an independent negative association between plasma ANGPTL2 and CKD‑EPI values. Further prospective studies on larger cohorts are needed to evaluate the pathogenetic role of ANGPTL2 as well as its use as a diagnostic marker of renal dysfunction.

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