Infection phase is a predictor of pruritus in patients with hepatitis B virus infection

Oeda,Satoshi; Takahashi,Hirokazu; Isoda,Hiroshi; Komukai,Sho; Imajo,Kento; Yoneda,Masato; Ono,Masafumi; Hyogo,Hideyuki; Kawaguchi,Takumi; Fujii,Hideki; Kawanaka,Miwa; Sumida,Yoshio; Tanaka,Saiyu; Kawamoto,Hirofumi; Torimura,Takuji; Saibara,Toshiji; Kawaguchi,Atsushi; Nakajima,Atsushi; Eguchi,Yuichiro

doi:10.3892/br.2019.1224

Infection phase is a predictor of pruritus in patients with hepatitis B virus infection

Authors:
- Satoshi Oeda
- Hirokazu Takahashi
- Hiroshi Isoda
- Sho Komukai
- Kento Imajo
- Masato Yoneda
- Masafumi Ono
- Hideyuki Hyogo
- Takumi Kawaguchi
- Hideki Fujii
- Miwa Kawanaka
- Yoshio Sumida
- Saiyu Tanaka
- Hirofumi Kawamoto
- Takuji Torimura
- Toshiji Saibara
- Atsushi Kawaguchi
- Atsushi Nakajima
- Yuichiro Eguchi
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Affiliations: Liver Center, Saga University, Saga‑Shi, Saga 849‑8501, Japan, Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga‑Shi, Saga 849‑8501, Japan, Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Suita‑Shi, Osaka 565‑0817, Japan, Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama‑Shi, Kanagawa 236‑0004, Japan, Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku‑Shi, Kochi 783‑8505, Japan, Department of Gastroenterology and Hepatology, JA Hiroshima General Hospital, Hatsukaichi‑Shi, Hiroshima 738‑8503, Japan, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume‑Shi, Fukuoka 830‑0011, Japan, Department of Gastroenterology and Hepatology, Osaka City Juso Hospital, Osaka‑Shi, Osaka 532‑0034, Japan, Department of General Internal Medicine, General Medical Center, Kawasaki Medical School, Okayama‑Shi, Okayama 700‑8505, Japan, Division of Hepatology and Pancreatology, Department of Internal Medicine, Aichi Medical University, Nagakute‑Shi, Aichi 480‑1195, Japan, Center for Digestive and Liver Diseases, Nara City Hospital, Nara‑Shi, Nara 630‑8305, Japan, Section of Clinical Cooperation System, Center for Comprehensive Community Medicine, Faculty of Medicine, Saga University, Saga‑Shi, Saga 849‑8501, Japan
Published online on: June 21, 2019 https://doi.org/10.3892/br.2019.1224
Pages: 63-69
Copyright : © Oeda et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Pruritus is a common pathogenesis in liver diseases, including chronic hepatitis B (CHB). The phases of hepatitis B virus (HBV) infection are defined in the American Association for the Study of Liver Diseases guidelines. However, it still remains unclear whether the phase independently affects pruritus. The aim of this study was to clarify the effect of HBV infection phase on pruritus in patients with HBV. Of the 1,631 patients that attended the joint research facilities and were interviewed regarding their pruritus between January and June 2016, 196 patients with HBV infection were selected for the present analysis. One‑to‑one propensity score‑matching using 13 variables was performed between participants in the hepatitis B e antigen (HBe‑Ag)‑positive/negative immune‑active phase group and the inactive CHB phase group. Data from 47 patients per group were included in the final analysis. The prevalence of pruritus in the inactive CHB phase was significantly lower than in the HBe‑Ag‑positive/negative immune‑active phase (23 vs. 47%; P=0.031). Being in the inactive CHB phase was determined to be an independent risk factor for pruritus (odds ratio, 0.35; 95% confidence interval, 0.143‑0.842; P=0.019). The progression to inactive CHB phase may contribute to the amelioration of pruritus in patients with HBV infection.

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