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Article Open Access

Red complex periodontal pathogens are risk factors for liver cirrhosis

  • Authors:
    • Yumiko Nagao
    • Takeshi Tanigawa
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    Affiliations: Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo 113‑8421, Japan
    Copyright: © Nagao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 199-206
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    Published online on: October 3, 2019
       https://doi.org/10.3892/br.2019.1245
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Abstract

Periodontal disease has been associated with liver disease; however, the identities of the periodontal disease‑causing bacteria in patients with viral liver disease remain unknown. The aim of the present study was to determine the counts of the 3 periodontal pathogens that form the red complex in chronic periodontitis (Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola) and 3 other bacteria (Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Fusobacterium necrophorum) in patients with liver disease. A total of 47 patients with liver disease were divided into two groups based on the counts of the red complex bacteria: group A (high counts of red complex bacteria) and group B (low counts of red complex bacteria). The counts of the 6 types of bacteria in saliva and the prevalence of P. gingivalis‑specific fimA genotype were determined. In addition, salivary occult blood tests and serological assays were performed. Univariate and multivariate logistic regression analyses were used to analyze the risk factors between the two groups of patients. Hepatitis C virus‑related liver disease was the most frequent (41/47; 87.2%) occurrence followed by liver cirrhosis (LC; 12/47; 25.5%) and oral lichen planus (32/47; 68.1%). The significant risk factors between the two groups were LC, albumin (Alb) level, ratios of each bacteria and prevalence of the fimA II genotype. The 3 factors identified in the multivariate analysis to be associated with the red complex bacteria count were low Alb level (<3.7 g/dl), LC and fimA II genotype, with adjusted odds ratios of 6.93, 4.72 and 4.08, respectively (P<0.05). These data indicated that patients with LC were at increased risk of presenting with the red complex bacteria leading to periodontal disease progression. Therefore, these patients may need to take additional care of their oral health compared with patients without LC, which may prove beneficial for the maintenance of their general health.
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1 

WHO: Hepatitis B Fact sheet July 2018. http://www.who.int/mediacentre/factsheets/fs204/en/.

2 

WHO: Hepatitis C Fact sheet July 2018. http://www.who.int/mediacentre/factsheets/fs164/en/.

3 

Umemura T, Ichijo T, Yoshizawa K, Tanaka E and Kiyosawa K: Epidemiology of hepatocellular carcinoma in Japan. J Gastroenterol. 44 (Suppl 19):102–107. 2009.PubMed/NCBI View Article : Google Scholar

4 

Asahina Y, Tsuchiya K, Tamaki N, Hirayama I, Tanaka T, Sato M, Yasui Y, Hosokawa T, Ueda K, Kuzuya T, et al: Effect of aging on risk for hepatocellular carcinoma in chronic hepatitis C virus infection. Hepatology. 52:518–527. 2010.PubMed/NCBI View Article : Google Scholar

5 

Tanaka J, Koyama T, Mizui M, Uchida S, Katayama K, Matsuo J, Akita T, Nakashima A, Miyakawa Y and Yoshizawa H: Total numbers of undiagnosed carriers of hepatitis C and B viruses in Japan estimated by age- and area-specific prevalence on the national scale. Intervirology. 54:185–195. 2011.PubMed/NCBI View Article : Google Scholar

6 

Tateishi R, Okanoue T, Fujiwara N, Okita K, Kiyosawa K, Omata M, Kumada H, Hayashi N and Koike K: Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: A large retrospective multicenter cohort study. J Gastroenterol. 50:350–360. 2015.PubMed/NCBI View Article : Google Scholar

7 

Tateishi R, Uchino K, Fujiwara N, Takehara T, Okanoue T, Seike M, Yoshiji H, Yatsuhashi H, Shimizu M, Torimura T, et al: A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update. J Gastroenterol. 54:367–376. 2019.PubMed/NCBI View Article : Google Scholar

8 

Al-Sharqi AJ: Periodontal status of patients with hepatitis B viruses and B and C virus (comparative study). J Pure Appl Microbiol. 12:293–300. 2018. View Article : Google Scholar

9 

Nagao Y, Sata M, Tanikawa K, Itoh K and Kameyama T: Lichen planus and hepatitis C virus in the northern Kyushu region of Japan. Eur J Clin Invest. 25:910–914. 1995.PubMed/NCBI View Article : Google Scholar

10 

Nagao Y, Sata M, Tanikawa K, Itoh K and Kameyama T: High prevalence of hepatitis C virus antibody and RNA in patients with oral cancer. J Oral Pathol Med. 24:354–360. 1995.PubMed/NCBI View Article : Google Scholar

11 

Williams RC: Periodontal disease. N Engl J Med. 322:373–382. 1990.PubMed/NCBI View Article : Google Scholar

12 

Socransky SS, Haffajee AD, Cugini MA, Smith C and Kent RL Jr: Microbial complexes in subgingival plaque. J Clin Periodontol. 25:134–144. 1998.PubMed/NCBI View Article : Google Scholar

13 

Lamont RJ and Jenkinson HF: Life below the gum line: Pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev. 62:1244–1263. 1998.PubMed/NCBI

14 

Tonetti MS, Chapple IL, Jepsen S and Sanz M: Primary and secondary prevention of periodontal and peri-implant diseases: Introduction to, and objectives of the 11th European Workshop on Periodontology consensus conference. J Clin Periodontol. 42 (Suppl 16):S1–S4. 2015.PubMed/NCBI View Article : Google Scholar

15 

Falcao A and Bullón P: A review of the influence of periodontal treatment in systemic diseases. Periodontol 2000. 79:117–128. 2019.PubMed/NCBI View Article : Google Scholar

16 

Bui FQ, Almeida-da-Silva CLC, Huynh B, Trinh A, Liu J, Woodward J, Asadi H and Ojcius DM: Association between periodontal pathogens and systemic disease. Biomed J. 42:27–35. 2019.PubMed/NCBI View Article : Google Scholar

17 

Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, Imajo K, Nomura R, Hokamura K, Ono M, et al: Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease. BMC Gastroenterol. 12(16)2012.PubMed/NCBI View Article : Google Scholar

18 

Alazawi W, Bernabe E, Tai D, Janicki T, Kemos P, Samsuddin S, Syn WK, Gillam D and Turner W: Periodontitis is associated with significant hepatic fibrosis in patients with non-alcoholic fatty liver disease. PLoS One. 12(e0185902)2017.PubMed/NCBI View Article : Google Scholar

19 

Nagao Y, Kawahigashi Y and Sata M: Association of periodontal diseases and liver fibrosis in patients with HCV and/or HBV infection. Hepat Mon. 14(e23264)2014.PubMed/NCBI View Article : Google Scholar

20 

Yasui T, Tanaka S, Onozawa H, Matsumoto M, Tanaka S and Nakao S: Mass screening of periodontal diseases using new test paper for detecting salivary occult bold. Nippon Shika Hyoron. 587:189–197. 1991.

21 

Kaufman E and Lamster IB: Analysis of saliva for periodontal diagnosis - a review. J Clin Periodontol. 27:453–465. 2000.PubMed/NCBI View Article : Google Scholar

22 

Tada A, Takeuchi H, Shimizu H, Tadokoro K, Tanaka K, Kawamura K, Yamaguchi T, Egashira T, Nomura Y and Hanada N: Quantification of periodontopathic bacteria in saliva using the invader assay. Jpn J Infect Dis. 65:415–423. 2012.PubMed/NCBI View Article : Google Scholar

23 

Tadokoro K, Yamaguchi T, Kawamura K, Shimizu H, Egashira T, Minabe M, Yoshino T and Oguchi H: Rapid quantification of periodontitis-related bacteria using a novel modification of Invader PLUS technologies. Microbiol Res. 165:43–49. 2010.PubMed/NCBI View Article : Google Scholar

24 

Lee SC, Antony A, Lee N, Leibow J, Yang JQ, Soviero S, Gutekunst K and Rosenstraus M: Improved version 2.0 qualitative and quantitative AMPLICOR reverse transcription-PCR tests for hepatitis C virus RNA: Calibration to international units, enhanced genotype reactivity, and performance characteristics. J Clin Microbiol. 38:4171–4179. 2000.PubMed/NCBI

25 

Sizmann D, Boeck C, Boelter J, Fischer D, Miethke M, Nicolaus S, Zadak M and Babiel R: Fully automated quantification of hepatitis C virus (HCV) RNA in human plasma and human serum by the COBAS AmpliPrep/COBAS TaqMan system. J Clin Virol. 38:326–333. 2007.PubMed/NCBI View Article : Google Scholar

26 

Dusheiko G, Schmilovitz-Weiss H, Brown D, McOmish F, Yap PL, Sherlock S, McIntyre N and Simmonds P: Hepatitis C virus genotypes: An investigation of type-specific differences in geographic origin and disease. Hepatology. 19:13–18. 1994.PubMed/NCBI View Article : Google Scholar

27 

Vallet-Pichard A, Mallet V, Nalpas B, Verkarre V, Nalpas A, Dhalluin-Venier V, Fontaine H and Pol S: FIB-4: An inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest. Hepatology. 46:32–36. 2007.PubMed/NCBI View Article : Google Scholar

28 

Shah AG, Lydecker A, Murray K, Tetri BN, Contos MJ and Sanyal AJ: Nash Clinical Research Network: Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 7:1104–1112. 2009.PubMed/NCBI View Article : Google Scholar

29 

American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 34 (Suppl 1): S62-S69, 2011.

30 

Beck JD, Slade G and Offenbacher S: Oral disease, cardiovascular disease and systemic inflammation. Periodontol 2000. 23:110–120. 2000.PubMed/NCBI View Article : Google Scholar

31 

Beukers NG, van der Heijden GJ, van Wijk AJ and Loos BG: Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60 174 participants in a large dental school in the Netherlands. J Epidemiol Community Health. 71:37–42. 2017.PubMed/NCBI View Article : Google Scholar

32 

Mealey BL and Oates TW: American Academy of Periodontology: Diabetes mellitus and periodontal diseases. J Periodontol. 77:1289–1303. 2006.PubMed/NCBI View Article : Google Scholar

33 

Whitmore SE and Lamont RJ: Oral bacteria and cancer. PLoS Pathog. 10(e1003933)2014.PubMed/NCBI View Article : Google Scholar

34 

Uppal A, Uppal S, Pinto A, Dutta M, Shrivatsa S, Dandolu V and Mupparapu M: The effectiveness of periodontal disease treatment during pregnancy in reducing the risk of experiencing preterm birth and low birth weight: A meta-analysis. J Am Dent Assoc. 141:1423–1434. 2010.PubMed/NCBI View Article : Google Scholar

35 

Scannapieco FA and Ho AW: Potential associations between chronic respiratory disease and periodontal disease: Analysis of National Health and Nutrition Examination Survey III. J Periodontol. 72:50–56. 2001.PubMed/NCBI View Article : Google Scholar

36 

Sparks Stein P, Steffen MJ, Smith C, Jicha G, Ebersole JL, Abner E and Dawson D III: Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease. Alzheimers Dement. 8:196–203. 2012.PubMed/NCBI View Article : Google Scholar

37 

Novacek G, Plachetzky U, Pötzi R, Lentner S, Slavicek R, Gangl A and Ferenci P: Dental and periodontal disease in patients with cirrhosis - role of etiology of liver disease. J Hepatol. 22:576–582. 1995.PubMed/NCBI View Article : Google Scholar

38 

Movin S: Relationship between periodontal disease and cirrhosis of the liver in humans. J Clin Periodontol. 8:450–458. 1981.PubMed/NCBI View Article : Google Scholar

39 

Funatsu K, Yamada M, Kawishima Y, Nishida J, Ueno M, Ebihara Y, Mizuno Y, Oda M and Tsuchiya M: Microcirculatory disturbances of oral mucosa and periodontal disease in patients with liver cirrhosis. J Gastroenterol Hepatol. 4 (Suppl 1):99–102. 1989.PubMed/NCBI

40 

Grønkjær LL: Periodontal disease and liver cirrhosis: A systematic review. SAGE Open Med. 3(2050312115601122)2015.PubMed/NCBI View Article : Google Scholar

41 

Farias BC, Souza PR, Ferreira B, Melo RS, Machado FB, Gusmão ES and Cimões R: Occurrence of periodontal pathogens among patients with chronic periodontitis. Braz J Microbiol. 43:909–916. 2012.PubMed/NCBI View Article : Google Scholar

42 

Katz J, Onate MD, Pauley KM, Bhattacharyya I and Cha S: Presence of Porphyromonas gingivalis in gingival squamous cell carcinoma. Int J Oral Sci. 3:209–215. 2011.PubMed/NCBI View Article : Google Scholar

43 

Ahn J, Segers S and Hayes RB: Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. Carcinogenesis. 33:1055–1058. 2012.PubMed/NCBI View Article : Google Scholar

44 

Michaud DS, Izard J, Wilhelm-Benartzi CS, You DH, Grote VA, Tjønneland A, Dahm CC, Overvad K, Jenab M, Fedirko V, et al: Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut. 62:1764–1770. 2013.PubMed/NCBI View Article : Google Scholar

45 

Matsushita K, Hamaguchi M, Hashimoto M, Yamazaki M, Yamazaki T, Asai K, Yamori M, Bessho K, Toda H, Hasegawa G, et al: The novel association between red complex of oral microbe and body mass index in healthy Japanese: A population based cross-sectional study. J Clin Biochem Nutr. 57:135–139. 2015.PubMed/NCBI View Article : Google Scholar

46 

Chigasaki O, Takeuchi Y, Aoki A, Sasaki Y, Mizutani K, Aoyama N, Ikeda Y, Gokyu M, Umeda M, Ishikawa I, et al: A cross-sectional study on the periodontal status and prevalence of red complex periodontal pathogens in a Japanese population. J Oral Sci. 60:293–303. 2018.PubMed/NCBI View Article : Google Scholar

47 

Hamada S, Fujiwara T, Morishima S, Takahashi I, Nakagawa I, Kimura S and Ogawa T: Molecular and immunological characterization of the fimbriae of Porphyromonas gingivalis. Microbiol Immunol. 38:921–930. 1994.PubMed/NCBI View Article : Google Scholar

48 

Amano A, Nakagawa I, Kataoka K, Morisaki I and Hamada S: Distribution of Porphyromonas gingivalis strains with fimA genotypes in periodontitis patients. J Clin Microbiol. 37:1426–1430. 1999.PubMed/NCBI

49 

Gustot T, Durand F, Lebrec D, Vincent JL and Moreau R: Severe sepsis in cirrhosis. Hepatology. 50:2022–2033. 2009.PubMed/NCBI View Article : Google Scholar

50 

Thalheimer U, Triantos CK, Samonakis DN, Patch D and Burroughs AK: Infection, coagulation, and variceal bleeding in cirrhosis. Gut. 54:556–563. 2005.PubMed/NCBI View Article : Google Scholar

51 

Ashare A, Stanford C, Hancock P, Stark D, Lilli K, Birrer E, Nymon A, Doerschug KC and Hunninghake GW: Chronic liver disease impairs bacterial clearance in a human model of induced bacteremia. Clin Transl Sci. 2:199–205. 2009.PubMed/NCBI View Article : Google Scholar

52 

Van Dyke TE and van Winkelhoff AJ: Infection and inflammatory mechanisms. J Periodontol. 84 (Suppl 4):S1–S7. 2013.PubMed/NCBI View Article : Google Scholar

53 

Scannapieco FA: The oral microbiome: Its role in health and in oral and systemic infections. Clin Mic News. 35:163–169. 2013. View Article : Google Scholar

54 

Qin N, Yang F, Li A, Prifti E, Chen Y, Shao L, Guo J, Le Chatelier E, Yao J, Wu L, et al: Alterations of the human gut microbiome in liver cirrhosis. Nature. 513:59–64. 2014.PubMed/NCBI View Article : Google Scholar

55 

Nakajima M, Arimatsu K, Kato T, Matsuda Y, Minagawa T, Takahashi N, Ohno H and Yamazaki K: Oral administration of P. gingivalis induces cysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver. PLoS One. 10(e0134234)2015.PubMed/NCBI View Article : Google Scholar

56 

Nishimura F and Murayama Y: Periodontal inflammation and insulin resistance--lessons from obesity. J Dent Res. 80:1690–1694. 2001.PubMed/NCBI View Article : Google Scholar

57 

Nagao Y, Hanada S, Shishido S, Ide T, Kumashiro R, Ueno T and Sata M: Incidence of Sjögren's syndrome in Japanese patients with hepatitis C virus infection. J Gastroenterol Hepatol. 18:258–266. 2003.PubMed/NCBI View Article : Google Scholar

58 

Tatsuoka S: Issue record of ‘Research to understand the actual situation of prejudice and discrimination against hepatitis virus infected people, and to prepare guidelines for prevention of the damage’ by Health, Labour and Welfare Sciences Research Grants. 2011-2013.(In Japanese).

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Spandidos Publications style
Nagao Y and Tanigawa T: Red complex periodontal pathogens are risk factors for liver cirrhosis. Biomed Rep 11: 199-206, 2019.
APA
Nagao, Y., & Tanigawa, T. (2019). Red complex periodontal pathogens are risk factors for liver cirrhosis. Biomedical Reports, 11, 199-206. https://doi.org/10.3892/br.2019.1245
MLA
Nagao, Y., Tanigawa, T."Red complex periodontal pathogens are risk factors for liver cirrhosis". Biomedical Reports 11.5 (2019): 199-206.
Chicago
Nagao, Y., Tanigawa, T."Red complex periodontal pathogens are risk factors for liver cirrhosis". Biomedical Reports 11, no. 5 (2019): 199-206. https://doi.org/10.3892/br.2019.1245
Copy and paste a formatted citation
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Spandidos Publications style
Nagao Y and Tanigawa T: Red complex periodontal pathogens are risk factors for liver cirrhosis. Biomed Rep 11: 199-206, 2019.
APA
Nagao, Y., & Tanigawa, T. (2019). Red complex periodontal pathogens are risk factors for liver cirrhosis. Biomedical Reports, 11, 199-206. https://doi.org/10.3892/br.2019.1245
MLA
Nagao, Y., Tanigawa, T."Red complex periodontal pathogens are risk factors for liver cirrhosis". Biomedical Reports 11.5 (2019): 199-206.
Chicago
Nagao, Y., Tanigawa, T."Red complex periodontal pathogens are risk factors for liver cirrhosis". Biomedical Reports 11, no. 5 (2019): 199-206. https://doi.org/10.3892/br.2019.1245
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