Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
August-2020 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review)

  • Authors:
    • Mutsumi Murakami
    • Yuka Ikeda
    • Yukie Nakagawa
    • Ai Tsuji
    • Yasuko Kitagishi
    • Satoru Matsuda
  • View Affiliations / Copyright

    Affiliations: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan
    Copyright: © Murakami et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1
    |
    Published online on: June 2, 2020
       https://doi.org/10.3892/br.2020.1310
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Dementia is a failure of cognitive ability characterized by severe neurodegeneration in select neural systems, and Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Although numerous studies have provided insights into the pathogenesis of AD, the underlying signaling and molecular pathways mediating the progressive decline of cognitive function remain poorly understood. Recent progress in molecular biology has provided an improved understanding of the importance of molecular pathogenesis of AD, and has proposed an association between DNA repair mechanisms and AD. In particular, the fundamental roles of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and breast cancer gene 1 (BRCA1) tumor suppressors have been shown to regulate the pathogenesis of neurodegeneration. Consequently, onset of neurodegenerative diseases may be deferred with the use of dietary neuroprotective agents which alter the signaling mediated by the aforementioned tumor suppressors. In a healthy neuron, homeostasis of key intracellular molecules is of great importance, and preventing neuronal apoptosis is one of the primary goals of treatments designed for dementia-associated diseases. In the present review, progress into the understanding of dietary regulation for preventing or limiting development of dementia is discussed with a focus on the modulatory roles of PTEN and BRCA1 signaling.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H and Tuomilehto J: Risk score for the prediction of dementia risk in 20 years among middle aged people: A longitudinal, population-based study. Lancet Neurol. 5:735–741. 2006.PubMed/NCBI View Article : Google Scholar

2 

Finneran DJ and Nash KR: Neuroinflammation and fractalkine signaling in Alzheimer's disease. J Neuroinflammation. 16(30)2019.PubMed/NCBI View Article : Google Scholar

3 

Trujillo-Estrada L, Dávila JC, Sánchez-Mejias E, Sánchez-Varo R, Gomez-Arboledas A, Vizuete M, Vitorica J and Gutiérrez A: Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum. J Alzheimers Dis. 42:521–541. 2014.PubMed/NCBI View Article : Google Scholar

4 

Zhao J, Gao W, Yang Z, Li H and Gao Z: Nitration of amyloid-β peptide (1-42) as a protective mechanism for the amyloid-β peptide (1-42) against copper ion toxicity. J Inorg Biochem. 190:15–23. 2019.PubMed/NCBI View Article : Google Scholar

5 

Tanzi RE: The genetics of Alzheimer disease. Cold Spring Harb Perspect Med. 2(a006296)2012.PubMed/NCBI View Article : Google Scholar

6 

Ravi SK, Narasingappa RB and Vincent B: Neuro-nutrients as anti-Alzheimer's disease agents: A critical review. Crit Rev Food Sci Nutr. 59:2999–3018. 2019.PubMed/NCBI View Article : Google Scholar

7 

Barus R, Béné J, Deguil J, Gautier S and Bordet R: Drug interactions with dementia-related pathophysiological pathways worsen or prevent dementia. Br J Pharmacol. 176:3413–3434. 2019.PubMed/NCBI View Article : Google Scholar

8 

Butterfield DA and Halliwell B: Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci. 20:148–160. 2019.PubMed/NCBI View Article : Google Scholar

9 

Tian JS, Zhai QJ, Zhao Y, Chen R and Zhao LD: 2-(2-benzofuranyl)-2-imidazoline (2-BFI) improved the impairments in AD rat models by inhibiting oxidative stress, inflammation and apoptosis. J Integr Neurosci. 16:385–400. 2017.PubMed/NCBI View Article : Google Scholar

10 

Perez Ortiz JM and Swerdlow RH: Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities. Br J Pharmacol. 176:3489–3507. 2019.PubMed/NCBI View Article : Google Scholar

11 

Chang KH, Cheng ML, Chiang MC and Chen CM: Lipophilic antioxidants in neurodegenerative diseases. Clin Chim Acta. 485:79–87. 2018.PubMed/NCBI View Article : Google Scholar

12 

Gugliandolo A, Bramanti P and Mazzon E: Role of Vitamin E in the treatment of Alzheimer's disease: Evidence from animal models. Int J Mol Sci. 18(E2504)2017.PubMed/NCBI View Article : Google Scholar

13 

Yu J, Zhu H, Taheri S, Mondy W, Perry S and Kindy MS: Impact of nutrition on inflammation, tauopathy, and behavioral outcomes from chronic traumatic encephalopathy. J Neuroinflammation. 15(277)2018.PubMed/NCBI View Article : Google Scholar

14 

Tako E, Bar H and Glahn RP: The combined application of the Caco-2 cell bioassay coupled with in vivo (Gallus gallus) feeding trial represents an effective approach to predicting Fe bioavailability in humans. Nutrients. 8(E732)2016.PubMed/NCBI View Article : Google Scholar

15 

Jazvinšćak Jembrek M, Hof PR and Šimić G: Ceramides in Alzheimer's disease: Key mediators of neuronal apoptosis induced by oxidative stress and Aβ accumulation. Oxid Med Cell Longev. 2015(346783)2015.PubMed/NCBI View Article : Google Scholar

16 

Mitra J, Guerrero EN, Hegde PM, Wang H, Boldogh I, Rao KS, Mitra S and Hegde ML: New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases. Biomolecules. 4:678–703. 2014.PubMed/NCBI View Article : Google Scholar

17 

Zhou DR, Eid R, Miller KA, Boucher E, Mandato CA and Greenwood MT: Intracellular second messengers mediate stress inducible hormesis and programmed cell death: A review. Biochim Biophys Acta Mol Cell Res. 1866:773–792. 2019.PubMed/NCBI View Article : Google Scholar

18 

Görlach A, Dimova EY, Petry A, Martínez-Ruiz A, Hernansanz-Agustín P, Rolo AP, Palmeira CM and Kietzmann T: Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? Redox Biol. 6:372–385. 2015.PubMed/NCBI View Article : Google Scholar

19 

Freund RK, Gibson ES, Potter H and Dell'Acqua ML: Inhibition of the Motor protein Eg5/Kinesin-5 in amyloid β-mediated impairment of hippocampal long-term potentiation and dendritic spine loss. Mol Pharmacol. 89:552–559. 2016.PubMed/NCBI View Article : Google Scholar

20 

Ikeda Y, Murakami M, Nakagawa Y, Tsuji A, Kitagishi Y and Matsuda S: Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling. Biomed Rep. 12:295–302. 2020.PubMed/NCBI View Article : Google Scholar

21 

Schaefer PM, von Einem B, Walther P, Calzia E and von Arnim CA: Metabolic characterization of intact cells reveals intracellular amyloid beta but not its precursor protein to reduce mitochondrial respiration. PLoS One. 11(e0168157)2016.PubMed/NCBI View Article : Google Scholar

22 

Richetin K, Moulis M, Millet A, Arràzola MS, Andraini T, Hua J, Davezac N, Roybon L, Belenguer P, Miquel MC and Rampon C: Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease. Neurobiol Dis. 102:113–124. 2017.PubMed/NCBI View Article : Google Scholar

23 

Canugovi C, Misiak M, Ferrarelli LK, Croteau DL and Bohr VA: The role of DNA repair in brain related disease pathology. DNA Repair (Amst). 12:578–587. 2013.PubMed/NCBI View Article : Google Scholar

24 

Ali R, Rakha EA, Madhusudan S and Bryant HE: DNA damage repair in breast cancer and its therapeutic implications. Pathology. 49:156–165. 2017.PubMed/NCBI View Article : Google Scholar

25 

Tokarz P, Kaarniranta K and Blasiak J: Role of the cell cycle Re-initiation in DNA damage response of post-mitotic cells and its implication in the pathogenesis of neurodegenerative diseases. Rejuvenation Res. 19:131–139. 2016.PubMed/NCBI View Article : Google Scholar

26 

Li WA, Moore-Langston S, Chakraborty T, Rafols JA, Conti AC and Ding Y: Hyperglycemia in stroke and possible treatments. Neurol Res. 35:479–491. 2013.PubMed/NCBI View Article : Google Scholar

27 

Mena S, Ortega A and Estrela JM: Oxidative stress in environmental-induced carcinogenesis. Mutat Res. 674:36–44. 2009.PubMed/NCBI View Article : Google Scholar

28 

Roh HT, Cho SY and So WY: Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise. J Sport Health Sci. 6:225–230. 2017.PubMed/NCBI View Article : Google Scholar

29 

Thirupathi A and Pinho RA: Effects of reactive oxygen species and interplay of antioxidants during physical exercise in skeletal muscles. J Physiol Biochem. 74:359–367. 2018.PubMed/NCBI View Article : Google Scholar

30 

Tsai CY, Wu JCC, Fang C and Chang AYW: PTEN, a negative regulator of PI3K/Akt signaling, sustains brain stem cardiovascular regulation during mevinphos intoxication. Neuropharmacology. 123:175–185. 2017.PubMed/NCBI View Article : Google Scholar

31 

Matsuda S, Ikeda Y, Murakami M, Nakagawa Y, Tsuji A and Kitagishi Y: Roles of PI3K/AKT/GSK3 pathway involved in psychiatric Illnesses. Diseases. 7: pii(E22)2019.PubMed/NCBI View Article : Google Scholar

32 

Ogino M, Ichimura M, Nakano N, Minami A, Kitagishi Y and Matsuda S: Roles of PTEN with DNA repair in Parkinson's disease. Int J Mol Sci. 17: pii(E954)2016.PubMed/NCBI View Article : Google Scholar

33 

Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, et al: PTEN recruitment controls synaptic and cognitive function in Alzheimer's models. Nat Neurosci. 19:443–453. 2016.PubMed/NCBI View Article : Google Scholar

34 

Chen CY, Chen J, He L and Stiles BL: PTEN: Tumor suppressor and metabolic regulator. Front Endocrinol (Lausanne). 9(338)2018.PubMed/NCBI View Article : Google Scholar

35 

Yi YW, Kang HJ, Kim HJ, Hwang JS, Wang A and Bae I: Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells. Mol Carcinog. 52:667–675. 2013.PubMed/NCBI View Article : Google Scholar

36 

Krivokuca A, Boljevic I, Jovandic S, Magic Z, Mandic A, Tomasevic Z and Brankovic-Magic M: Germline mutations in cancer susceptibility genes in high grade serous ovarian cancer in Serbia. J Hum Genet. 64:281–290. 2019.PubMed/NCBI View Article : Google Scholar

37 

Yoshino Y, Endo S, Chen Z, Qi H, Watanabe G and Chiba N: Evaluation of site-specific homologous recombination activity of BRCA1 by direct quantitation of gene editing efficiency. Sci Rep. 9(1644)2019.PubMed/NCBI View Article : Google Scholar

38 

Savage KI and Harkin DP: BRCA1, a ‘complex’ protein involved in the maintenance of genomic stability. FEBS J. 282:630–646. 2015.PubMed/NCBI View Article : Google Scholar

39 

Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC and Price BD: DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem. 280:15158–15164. 2005.PubMed/NCBI View Article : Google Scholar

40 

Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, et al: DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Nat Commun. 6(8897)2015.PubMed/NCBI View Article : Google Scholar

41 

Moruno-Manchon JF, Koellhoffer EC, Gopakumar J, Hambarde S, Kim N, McCullough LD and Tsvetkov AS: The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 9:1957–1970. 2017.PubMed/NCBI View Article : Google Scholar

42 

So EY and Ouchi T: BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction. BMC Cancer. 14(548)2014.PubMed/NCBI View Article : Google Scholar

43 

Tanaka H, Phipps EA, Wei T, Wu X, Goswami C, Liu Y, Sledge GW Jr, Mina L and Herbert BS: Altered expression of telomere-associated genes in leukocytes among BRCA1 and BRCA2 carriers. Mol Carcinog. 57:567–575. 2018.PubMed/NCBI View Article : Google Scholar

44 

Zhan Y and Hägg S: Telomere length dhortening in Alzheimer's disease: Procedures for a causal investigation using single nucleotide polymorphisms in a mendelian randomization study. Methods Mol Biol. 1750:293–306. 2018.PubMed/NCBI View Article : Google Scholar

45 

Minami A, Nakanishi A, Ogura Y, Kitagishi Y and Matsuda S: Connection between Tumor Suppressor BRCA1 and PTEN in damaged DNA repair. Front Oncol. 4(318)2014.PubMed/NCBI View Article : Google Scholar

46 

Maidarti M, Clarkson YL, McLaughlin M, Anderson RA and Telfer EE: Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response. Hum Reprod. 34:297–307. 2019.PubMed/NCBI View Article : Google Scholar

47 

A. Zhao C, Noble JM, Marder K, Hartman JS, Gu Y and Scarmeas N: Dietary patterns, physical activity, sleep, and risk for dementia and cognitive decline. Curr Nutr Rep. 7:335–345. 2018.PubMed/NCBI View Article : Google Scholar

48 

Liu D, Wang Z, Gao Z, Xie K, Zhang Q, Jiang H and Pang Q: Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress. Behav Brain Res. 271:116–121. 2014.PubMed/NCBI View Article : Google Scholar

49 

Sang Q, Sun D, Chen Z and Zhao W: GF and PI3K/Akt signaling participate in the ventral motor neuronal protection of curcumin in sciatic nerve injury rat models. Biomed Pharmacother. 103:1146–1153. 2018.PubMed/NCBI View Article : Google Scholar

50 

Hussein RM, Mohamed WR and Omar HA: A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3β-Nrf2 signaling pathway. Pestic Biochem Physiol. 152:29–37. 2018.PubMed/NCBI View Article : Google Scholar

51 

Wu B, Luo H, Zhou X, Cheng CY, Lin L, Liu BL, Liu K, Li P and Yang H: Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: Therapeutical effects of kaempferol. Biochim Biophys Acta Mol Basis Dis. 1863:2307–2318. 2017.PubMed/NCBI View Article : Google Scholar

52 

Shen R and Wang JH: The effect of Icariin on immunity and its potential application. Am J Clin Exp Immunol. 7:50–56. 2018.PubMed/NCBI

53 

Yoshida H, Okumura N, Kitagishi Y, Nishimura Y and Matsuda S: Ethanol extract of Rosemary repressed PTEN expression in K562 culture cells. Int J App Biol Pharmaceutical. 2:316–322. 2011.

54 

Lu M, Fei Z and Zhang G: Synergistic anticancer activity of 20(S)-Ginsenoside Rg3 and Sorafenib in hepatocellular carcinoma by modulating PTEN/Akt signaling pathway. Biomed Pharmacother. 97:1282–1288. 2018.PubMed/NCBI View Article : Google Scholar

55 

Chalabi N, Le Corre L, Maurizis JC, Bignon YJ and Bernard-Gallon DJ: The effects of lycopene on the proliferation of human breast cells and BRCA1 and BRCA2 gene expression. Eur J Cancer. 40:1768–1775. 2004.PubMed/NCBI View Article : Google Scholar

56 

Chalabi N, Maurizis JC, Le Corre L, Delort L, Bignon YJ and Bernard-Gallon DJ: Quantification by affinity perfusion chromatography of phosphorylated BRCAl and BRCA2 proteins from tumor cells after lycopene treatment. J Chromatogr B Analyt Technol Biomed Life Sci. 821:188–193. 2005.PubMed/NCBI View Article : Google Scholar

57 

Bosviel R, Dumollard E, Déchelotte P, Bignon YJ and Bernard-Gallon D: Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer? OMICS. 16:235–244. 2012.PubMed/NCBI View Article : Google Scholar

58 

Vissac-Sabatier C, Coxam V, Déchelotte P, Picherit C, Horcajada MN, Davicco MJ, Lebecque P, Bignon YJ and Bernard-Gallon D: Phytoestrogen-rich diets modulate expression of Brca1 and Brca2 tumor suppressor genes in mammary glands of female Wistar rats. Cancer Res. 63:6607–6612. 2003.PubMed/NCBI

59 

Cabanes A, Wang M, Olivo S, DeAssis S, Gustafsson JA, Khan G and Hilakivi-Clarke L: Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis. 25:741–748. 2004.PubMed/NCBI View Article : Google Scholar

60 

Soni M, Rahardjo TB, Soekardi R, Sulistyowati Y, Lestariningsih Yesufu-Udechuku A, Irsan A and Hogervorst E: Phytoestrogens and cognitive function: A review. Maturitas. 77:209–220. 2014.PubMed/NCBI View Article : Google Scholar

61 

Weng SW, Hsu SC, Liu HC, Ji BC, Lien JC, Yu FS, Liu KC, Lai KC, Lin JP and Chung JG: Gallic acid induces DNA damage and inhibits DNA repair-associated protein expression in human oral cancer SCC-4 cells. Anticancer Res. 35:2077–2084. 2015.PubMed/NCBI

62 

Taysi S, Tascan AS, Ugur MG and Demir M: Radicals, oxidative/nitrosative stress and preeclampsia. Mini Rev Med Chem. 19:178–193. 2019.PubMed/NCBI View Article : Google Scholar

63 

Vehviläinen P, Koistinaho J and Gundars G: Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis. Front Cell Neurosci. 8(126)2014.PubMed/NCBI View Article : Google Scholar

64 

Sakellariou GK, Davis CS, Shi Y, Ivannikov MV, Zhang Y, Vasilaki A, Macleod GT, Richardson A, Van Remmen H, Jackson MJ, et al: Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice. FASEB J. 28:1666–1681. 2014.PubMed/NCBI View Article : Google Scholar

65 

Bravard A, Sabatier L, Hoffschir F, Ricoul M, Luccioni C and Dutrillaux B: SOD2: A new type of tumor-suppressor gene? Int J Cancer. 51:476–480. 1992.PubMed/NCBI View Article : Google Scholar

66 

Dixit S, Fessel JP and Harrison FE: Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate. Free Radic Biol Med. 112:515–523. 2017.PubMed/NCBI View Article : Google Scholar

67 

Demchenko IT, Gutsaeva DR, Moskvin AN and Zhilyaev SY: Involvement of extracellular superoxide dismutase in regulating brain blood flow. Neurosci Behav Physiol. 40:173–178. 2010.PubMed/NCBI View Article : Google Scholar

68 

Singh B and Bhat HK: Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer. Carcinogenesis. 33:2601–2610. 2012.PubMed/NCBI View Article : Google Scholar

69 

Natarajan G, Perriotte-Olson C, Casey CA, Donohue TM Jr, Talmon GA, Harris EN, Kabanov AV and Saraswathi V: Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue. Alcohol. 79:71–79. 2019.PubMed/NCBI View Article : Google Scholar

70 

Janyou A, Wicha P, Jittiwat J, Suksamrarn A, Tocharus C and Tocharus J: Dihydrocapsaicin attenuates blood brain barrier and cerebral damage in focal cerebral ischemia/reperfusion via oxidative stress and inflammatory. Sci Rep. 7(10556)2017.PubMed/NCBI View Article : Google Scholar

71 

Lee SH, Kim JK and Jang HD: Genistein inhibits osteoclastic differentiation of RAW 264.7 cells via regulation of ROS production and scavenging. Int J Mol Sci. 15:10605–10621. 2014.PubMed/NCBI View Article : Google Scholar

72 

Sheriff SA, Shaik Ibrahim S, Devaki T, Chakraborty S, Agarwal S and Pérez-Sánchez H: Lycopene prevents mitochondrial dysfunction during d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in albino rats. J Proteome Res. 16:3190–3199. 2017.PubMed/NCBI View Article : Google Scholar

73 

Desjardins F, Sekkali B, Verreth W, Pelat M, De Keyzer D, Mertens A, Smith G, Herregods MC, Holvoet P and Balligand JL: Rosuvastatin increases vascular endothelial PPARgamma expression and corrects blood pressure variability in obese dyslipidaemic mice. Eur Heart J. 29:128–137. 2008.PubMed/NCBI View Article : Google Scholar

74 

Chatterjee A, Ronghe A, Padhye SB, Spade DA, Bhat NK and Bhat HK: Antioxidant activities of novel resveratrol analogs in breast cancer. J Biochem Mol Toxicol. 32(e21925)2018.PubMed/NCBI View Article : Google Scholar

75 

Ribeiro CCD, Silva RM, Campanholo VMLP, Ribeiro DA, Ribeiro Paiotti AP and Forones NM: Effects of Grape Juice in superoxide dismutase and catalase in colorectal cancer carcinogenesis induced by Azoxymethane. Asian Pac J Cancer Prev. 19:2839–2844. 2018.PubMed/NCBI View Article : Google Scholar

76 

Geeraert B, Crombé F, Hulsmans M, Benhabilès N, Geuns JM and Holvoet P: Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice. Int J Obes (Lond). 34:569–577. 2010.PubMed/NCBI View Article : Google Scholar

77 

Ma N, Abaker JA, Bilal MS, Dai H and Shen X: Sodium butyrate improves antioxidant stability in sub-acute ruminal acidosis in dairy goats. BMC Vet Res. 14(275)2018.PubMed/NCBI View Article : Google Scholar

78 

von Arnim CA, Herbolsheimer F, Nikolaus T, Peter R, Biesalski HK, Ludolph AC, Riepe M and Nagel G: ActiFE Ulm Study Group. Dietary antioxidants and dementia in a population-based case-control study among older people in South Germany. J Alzheimers Dis. 31:717–724. 2012.PubMed/NCBI View Article : Google Scholar

79 

de Oliveira BF, Veloso CA, Nogueira-Machado JA, de Moraes EN, dos Santos RR, Cintra MT and Chaves MM: Ascorbic acid, alpha-tocopherol, and beta-carotene reduce oxidative stress and proinflammatory cytokines in mononuclear cells of Alzheimer's disease patients. Nutr Neurosci. 15:244–251. 2012.PubMed/NCBI View Article : Google Scholar

80 

Ghanbari AA, Shabani K and Mohammad Nejad D: Protective effects of Vitamin E consumption against 3MT electromagnetic field effects on oxidative parameters in Substantia Nigra in Rats. Basic Clin Neurosci. 7:315–322. 2016.PubMed/NCBI View Article : Google Scholar

81 

Thiriot C, Durand P, Jasseron MP, Kergonou JF and Ducousso R: Radiosensitive antioxidant membrane-bound factors in rat liver microsomes: I. The roles of glutathione and vitamin E. Biochem Int. 14:1–8. 1987.PubMed/NCBI

82 

Vinot N, Jouin M, Lhomme-Duchadeuil A, Guesnet P, Alessandri JM, Aujard F and Pifferi F: Omega-3 fatty acids from fish oil lower anxiety, improve cognitive functions and reduce spontaneous locomotor activity in a non-human primate. PLoS One. 6(e20491)2011.PubMed/NCBI View Article : Google Scholar

83 

Ray SD, Parmar M, Syed I, Rathod J, Zinkovsky D, Bulku E, Gigliotti J, Hackman RM and Stohs SJ: Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non-genomic changes in the liver of female B6C3F1 mice. Phytother Res. 22:458–71. 2008.PubMed/NCBI View Article : Google Scholar

84 

Lee J, Park S, Lee JY, Yeo YK, Kim JS and Lim J: Improved spatial learning and memory by perilla diet is correlated with immunoreactivities to neurofilament and α-synuclein in hilus of dentate gyrus. Proteome Sci. 10(72)2012.PubMed/NCBI View Article : Google Scholar

85 

Byun EB, Cho EJ, Kim YE, Kim WS and Byun EH: Neuroprotective effect of polysaccharide separated from Perilla frutescens Britton var acuta Kudo against H2O2-induced oxidative stress in HT22 hippocampus cells. Biosci Biotechnol Biochem. 82:1344–1358. 2018.PubMed/NCBI View Article : Google Scholar

86 

Vallés SL, Borrás C, Gambini J, Furriol J, Ortega A, Sastre J, Pallardó FV and Viña J: Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38. Aging Cell. 7:112–118. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Murakami M, Ikeda Y, Nakagawa Y, Tsuji A, Kitagishi Y and Matsuda S: Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review). Biomed Rep 13: 1, 2020.
APA
Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y., & Matsuda, S. (2020). Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review). Biomedical Reports, 13, 1. https://doi.org/10.3892/br.2020.1310
MLA
Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y., Matsuda, S."Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review)". Biomedical Reports 13.2 (2020): 1.
Chicago
Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y., Matsuda, S."Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review)". Biomedical Reports 13, no. 2 (2020): 1. https://doi.org/10.3892/br.2020.1310
Copy and paste a formatted citation
x
Spandidos Publications style
Murakami M, Ikeda Y, Nakagawa Y, Tsuji A, Kitagishi Y and Matsuda S: Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review). Biomed Rep 13: 1, 2020.
APA
Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y., & Matsuda, S. (2020). Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review). Biomedical Reports, 13, 1. https://doi.org/10.3892/br.2020.1310
MLA
Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y., Matsuda, S."Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review)". Biomedical Reports 13.2 (2020): 1.
Chicago
Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y., Matsuda, S."Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review)". Biomedical Reports 13, no. 2 (2020): 1. https://doi.org/10.3892/br.2020.1310
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team