Open Access

Two‑component signaling pathways modulate drug resistance of Staphylococcus aureus (Review)

  • Authors:
    • Shizhou Wu
    • Kaifeng Lin
    • Yunjie Liu
    • Hui Zhang
    • Lei Lei
  • View Affiliations

  • Published online on: June 9, 2020     https://doi.org/10.3892/br.2020.1312
  • ArticleNumber: 5
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

As the issues surrounding antibiotic‑resistant strains of Staphylococcus aureus (S. aureus) are becoming increasingly serious concerns, it is imperative to investigate new therapeutic targets to successfully treat patients with S. aureus infections. The two‑component signal transduction system is one of the primary pathways by which bacteria adapt to the external environment, and it serves an important role in regulating virulence gene expression, cell wall synthesis, biofilm formation and bacterial activity. There are 17 two‑component signaling pathways in S. aureus, among which WalKR/VicSR/YycGF, AirSR/YhcSR, vancomycin resistance associated regulator/sensor and LytRS have been demonstrated to serve vital roles in regulating bacterial resistance, and are hypothesized to be potential targets for the treatment of S. aureus infections. The present review assesses the mechanism of the two‑component signaling pathways associated with the development of S. aureus resistance.
View Figures
View References

Related Articles

Journal Cover

August-2020
Volume 13 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wu S, Lin K, Liu Y, Zhang H and Lei L: Two‑component signaling pathways modulate drug resistance of Staphylococcus aureus (Review). Biomed Rep 13: 5, 2020
APA
Wu, S., Lin, K., Liu, Y., Zhang, H., & Lei, L. (2020). Two‑component signaling pathways modulate drug resistance of Staphylococcus aureus (Review). Biomedical Reports, 13, 5. https://doi.org/10.3892/br.2020.1312
MLA
Wu, S., Lin, K., Liu, Y., Zhang, H., Lei, L."Two‑component signaling pathways modulate drug resistance of Staphylococcus aureus (Review)". Biomedical Reports 13.2 (2020): 5.
Chicago
Wu, S., Lin, K., Liu, Y., Zhang, H., Lei, L."Two‑component signaling pathways modulate drug resistance of Staphylococcus aureus (Review)". Biomedical Reports 13, no. 2 (2020): 5. https://doi.org/10.3892/br.2020.1312