Two‑component signaling pathways modulate drug resistance of Staphylococcus aureus (Review)
- Shizhou Wu
- Kaifeng Lin
- Yunjie Liu
- Hui Zhang
- Lei Lei
Affiliations: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, P.R. China
- Published online on: June 9, 2020 https://doi.org/10.3892/br.2020.1312
Copyright: © Wu
et al. This is an open access article distributed under the
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As the issues surrounding antibiotic‑resistant strains of Staphylococcus aureus (S. aureus) are becoming increasingly serious concerns, it is imperative to investigate new therapeutic targets to successfully treat patients with S. aureus infections. The two‑component signal transduction system is one of the primary pathways by which bacteria adapt to the external environment, and it serves an important role in regulating virulence gene expression, cell wall synthesis, biofilm formation and bacterial activity. There are 17 two‑component signaling pathways in S. aureus, among which WalKR/VicSR/YycGF, AirSR/YhcSR, vancomycin resistance associated regulator/sensor and LytRS have been demonstrated to serve vital roles in regulating bacterial resistance, and are hypothesized to be potential targets for the treatment of S. aureus infections. The present review assesses the mechanism of the two‑component signaling pathways associated with the development of S. aureus resistance.