HOXC10 is significantly overexpressed in colorectal cancer

Enteghami,Mahboubeh; Ghorbani,Mahsa; Zamani,Mina; Galehdari,Hamid

doi:10.3892/br.2020.1325

HOXC10 is significantly overexpressed in colorectal cancer

Authors:
- Mahboubeh Enteghami
- Mahsa Ghorbani
- Mina Zamani
- Hamid Galehdari
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Affiliations: Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Khuzestan 6155661112, Iran
Published online on: July 28, 2020 https://doi.org/10.3892/br.2020.1325
Article Number: 18

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Abstract

Colorectal cancer (CRC) is one of the most common types of cancer in world and has a high rate of mortality. The majority of cases of CRC are sporadic; however, factors such as age, a family history of inflammatory diseases, diet, lifestyle and genetics increase the risk. HOX genes and lncRNAs are two classes of genes, and alterations in the expression levels of these genes are significantly associated with numerous different types of cancer. In the present study, the expression levels of HOXC10, HOXC‑AS3, HOTAIR, HOXC13 and HOXC13‑AS in tumor tissues were compared with normal healthy tissues in patients with CRC. Paired tumor and normal tissues were collected from 39 patients with CRC, and reverse transcription‑quantitative PCR was used the expression of HOXC‑AS3, HOXC13 and HOXC10 in the tumor tissues compared with the respective normal tissues. Expression of these genes were increased in the tumor tissues compared with normal tissues; however, the difference was only significant for HOXC10. Additionally, there was a strong and significant correlation between the expression of HOTAIR and HOXC13, a moderate and significant correlation between the expression of HOTAIR and HOXC13‑AS, and between HOXC13 and HOXC13‑AS genes. The expression of HOXC10 was significantly higher in tumor tissues compared with the normal tissues; whereas the upregulation of HOXC‑AS3 and HOXC13 were not significant. Only the correlation between the expression of HOTAIR and HOXC13 was strong and significant. As HOXC10 expression was significantly upregulated in the tumor tissues relative to normal tissues, it may serve as a biomarker for the diagnosis of CRC and as a potential therapeutic target.

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