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Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer

  • Authors:
    • Qinfei Zhao
    • Huaying Li
    • Longyu Zhu
    • Suping Hu
    • Xuxiang Xi
    • Yanmei Liu
    • Jianfeng Liu
    • Tianyu Zhong

  • View Affiliations

  • Published online on: July 9, 2020     https://doi.org/10.3892/br.2020.1328
  • Article Number: 21

  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer (CC) is one of the most prevalent types of cancer affecting females worldwide. However, the molecular mechanisms underlying the development and progression of CC remains to be elucidated. Taking the high incidence and mortality rates amongst women into consideration, the identification of novel biomarkers to prevent CC is of great significance and required to improve diagnosis. Using three raw microarray datasets from the Gene Expression Omnibus database, 188 differentially expressed genes (DEGs) were identified. Gene Ontology and pathway analyses were performed on the DEGs. Through protein‑protein interaction network construction and module analysis, eight hub genes [cell division cycle 6, cyclin‑dependent kinase 1 (CDK1), cell division control protein 45, budding uninhibited by benzimidazoles 1 (BUB1), DNA topoisomerase II α (TOP2A) and minichromosome maintenance complex component 4, CCNB2 and CCNB1] were identified, but only TOP2A was considered a prognostic factor in survival analysis. There were strong positive correlations between TOP2A and BUB1 (P<0.0001, rs=0.635), CDK1 (P<0.0001, rs=0.511), centromere protein F (CENPF) (P<0.0001, rs=0.677), Rac GTPase activating protein 1 (RACGAP1) (P<0.0001, rs=0.612), F‑box protein 5 (FBXO5) (P<0.0001, rs=0.585) and BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) (P<0.0001, rs=0.584). Additionally, BUB1, CDK1, CENPF, RACGAP1, FBXO5 and BUB1B are all potentially suitable candidate targets for the diagnosis and treatment of CC. In conclusion, the present study identified TOP2A as a potential tumor oncogene and a biomarker for the prognosis of CC.
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October-2020
Volume 13 Issue 4

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Online ISSN:2049-9442

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Spandidos Publications style
Zhao Q, Li H, Zhu L, Hu S, Xi X, Liu Y, Liu J and Zhong T: Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer. Biomed Rep 13: 21, 2020
APA
Zhao, Q., Li, H., Zhu, L., Hu, S., Xi, X., Liu, Y. ... Zhong, T. (2020). Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer. Biomedical Reports, 13, 21. https://doi.org/10.3892/br.2020.1328
MLA
Zhao, Q., Li, H., Zhu, L., Hu, S., Xi, X., Liu, Y., Liu, J., Zhong, T."Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer". Biomedical Reports 13.4 (2020): 21.
Chicago
Zhao, Q., Li, H., Zhu, L., Hu, S., Xi, X., Liu, Y., Liu, J., Zhong, T."Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer". Biomedical Reports 13, no. 4 (2020): 21. https://doi.org/10.3892/br.2020.1328