Lifeceramics‑treated water reduces serum uric acid levels and improves hemorheological activity in hyperuricemic rats

Li,Kuihua; Tong,Xiaobo; Yu,Jingyao; Gao,Xiaotao; Gao,Fuhong; Liu,Xiaosong; Suzuki,Atsushi; Kita,Kazuko; Suzuki,Nobuo

doi:10.3892/br.2020.1329

October-2020 Volume 13 Issue 4

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October-2020 Volume 13 Issue 4

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Lifeceramics‑treated water reduces serum uric acid levels and improves hemorheological activity in hyperuricemic rats

Authors:
- Kuihua Li
- Xiaobo Tong
- Jingyao Yu
- Xiaotao Gao
- Fuhong Gao
- Xiaosong Liu
- Atsushi Suzuki
- Kazuko Kita
- Nobuo Suzuki
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Affiliations: Hemorheology Center, Chengde Medical University, Chengde, Hebei 067000, P.R. China, Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan, Department of Cardiology, Tokyo Women's Medical University, Tokyo 162‑8666, Japan, Non‑Profit Organization, Chiba Researchers Network for Health Care Promotion, Chiba 260‑8670, Japan

Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 22
|
Published online on: July 17, 2020

https://doi.org/10.3892/br.2020.1329
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Abstract

Lifeceramics (LC) is made of zeolite and oyster shell and is hypothesized to act as an anti‑oxidative agent. In the present study, the effects of LC‑treated water (LC water) on the concentration of serum uric acid (SUA) and the hemorheological parameters in male rats with hyperuricemia (HUA) was assessed. To prepare LC water, distilled water was mixed with LC particles. HUA was induced in rats by daily potassium oxonate (PO) injection (250 mg/kg). The PO‑injected rats were separated into three different groups and were administered distilled water (PO rats), allopurinol [a xanthine oxidase (XOD) inhibitor] solution [PO + allopurinol (AP) rats] or LC water (PO+LC rats) by gavage. Control rats were intraperitoneally injected with sodium carboxymethyl cellulose solution and administered untreated distilled water by gavage. After injection and gavage for 5 weeks, the SUA concentration, hemorheology index and antioxidant index were measured. The SUA concentration and blood deformation index of the PO rats were significantly higher and lower, respectively, compared with the control rats. However, in the PO+LC rats, the SUA concentration and blood deformation index decreased and increased, respectively, to a level similar to that of the control as well as that in the PO+AP rats. Furthermore, the PO‑induced increase in XOD activity was suppressed by combined treatment with LC water, resulting in a decrease in malondialdehyde concentration. These results suggest that LC water can reduce the SUA concentration, increase serum antioxidant activity and improve hemorheological activity in hyperuricemic rats.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Lifeceramics‑treated water reduces serum uric acid levels and improves hemorheological activity in hyperuricemic rats

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