Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
- Anna Choromanska
- Julita Kulbacka
- Jolanta Saczko
- Pawel Surowiak
Affiliations: Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, 50‑556 Wroclaw, Poland, Department of Histology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50‑368 Wroclaw, Poland
- Published online on: July 31, 2020 https://doi.org/10.3892/br.2020.1339
Copyright: © Choromanska
et al. This is an open access article distributed under the
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Gliomas are a group of malignant brain tumors. Despite significant efforts to optimize treatment options for patients with high‑grade glioma, the prognosis of the overwhelming majority of patients remain poor. This bleak prognosis despite treatment of the glioma, is partly due to the tendency of therapeutics to diffusely penetrate into the neighboring brain tissues, but also due to the innate resistance of these tumors to chemotherapy and radiation. Garlic contains water‑soluble and oil‑soluble sulfur compounds. The oil‑soluble compounds, including diallyl sulfide, diallyl disulfide (DADS), diallyl trisulfide and ajoene, are more effective potential anti‑cancer treatments than the water‑soluble compounds. There are several studies examining the effects of oil‑soluble compounds on various types of cancer cells, although, to the best of our knowledge, there are no studies examining the effects of these compounds on glioma cells. The aim of the present study was to investigate the potential anti‑glioma properties of DAD and garlic oil on proliferation and induction of apoptosis in four different types of glioma cell lines representative of different grades of the disease. The results showed that garlic oil exhibits favorable anti‑cancer potential towards gliomas of various degrees of differentiation.