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Case Report Open Access

Diagnosis by molecular pathology of an early and atypical histoplasmosis lesion in the duodenum of an immunocompromised patient: A case report

  • Authors:
    • Sayoko Sumiyoshi
    • Shinichi Tanaka
    • Hirotomo Kato
    • Kohji Takagi
    • Takashi Minamisaka
    • Akira Noguchi
    • Takahiko Nakajima
    • Johji Imura
  • View Affiliations / Copyright

    Affiliations: Medical Department, Faculty of Medicine, University of Toyama, Toyama 930‑0194, Japan, Department of Diagnostic Pathology, Field of Medical, Academic Assembly, University of Toyama, Toyama 930‑0194, Japan, Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Shimotsuke, Tochigi 329‑0498, Japan
    Copyright: © Sumiyoshi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 6
    |
    Published online on: October 30, 2020
       https://doi.org/10.3892/br.2020.1382
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Abstract

Histoplasmosis is a fungal infection caused by Histoplasma capsulatum (HC), which can occasionally be aggressive resulting in the formation of granulomatous lesions. These are usually located in the lungs; however, immunocompromised patients may occasionally develop disseminated lesions in other organs as well. Human immunodeficiency virus (HIV) primarily infects cells of the immune system expressing CD4 molecules. Not only does HIV multiply within these cells, but it can also kill them or otherwise cause loss of cellular function, leading to an immunocompromised state. As a result, in an immunocompromised patient, infection with HC can have serious implications, often the development of visceral histoplasmosis in different organs. Although several types of lesions are formed in HC‑infected organs, it may be difficult to distinguish the causative organism from other pathogens based on morphology alone. The present case report describes the case of a 57‑year‑old woman, from South America, who may have been infected with HC >20 years previously, remaining asymptomatic over the years. She later developed a lesion in the duodenum associated with immunodeficiency caused by HIV infection. The differential diagnosis of this case was made on the basis of several specific morphological findings using histopathological analysis and molecular pathological techniques. The pathogenesis of characteristic lesions caused by HC in the presence of HIV infection was also reviewed.
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Copy and paste a formatted citation
Spandidos Publications style
Sumiyoshi S, Tanaka S, Kato H, Takagi K, Minamisaka T, Noguchi A, Nakajima T and Imura J: Diagnosis by molecular pathology of an early and atypical histoplasmosis lesion in the duodenum of an immunocompromised patient: A case report. Biomed Rep 14: 6, 2021.
APA
Sumiyoshi, S., Tanaka, S., Kato, H., Takagi, K., Minamisaka, T., Noguchi, A. ... Imura, J. (2021). Diagnosis by molecular pathology of an early and atypical histoplasmosis lesion in the duodenum of an immunocompromised patient: A case report. Biomedical Reports, 14, 6. https://doi.org/10.3892/br.2020.1382
MLA
Sumiyoshi, S., Tanaka, S., Kato, H., Takagi, K., Minamisaka, T., Noguchi, A., Nakajima, T., Imura, J."Diagnosis by molecular pathology of an early and atypical histoplasmosis lesion in the duodenum of an immunocompromised patient: A case report". Biomedical Reports 14.1 (2021): 6.
Chicago
Sumiyoshi, S., Tanaka, S., Kato, H., Takagi, K., Minamisaka, T., Noguchi, A., Nakajima, T., Imura, J."Diagnosis by molecular pathology of an early and atypical histoplasmosis lesion in the duodenum of an immunocompromised patient: A case report". Biomedical Reports 14, no. 1 (2021): 6. https://doi.org/10.3892/br.2020.1382
Copy and paste a formatted citation
x
Spandidos Publications style
Sumiyoshi S, Tanaka S, Kato H, Takagi K, Minamisaka T, Noguchi A, Nakajima T and Imura J: Diagnosis by molecular pathology of an early and atypical histoplasmosis lesion in the duodenum of an immunocompromised patient: A case report. Biomed Rep 14: 6, 2021.
APA
Sumiyoshi, S., Tanaka, S., Kato, H., Takagi, K., Minamisaka, T., Noguchi, A. ... Imura, J. (2021). Diagnosis by molecular pathology of an early and atypical histoplasmosis lesion in the duodenum of an immunocompromised patient: A case report. Biomedical Reports, 14, 6. https://doi.org/10.3892/br.2020.1382
MLA
Sumiyoshi, S., Tanaka, S., Kato, H., Takagi, K., Minamisaka, T., Noguchi, A., Nakajima, T., Imura, J."Diagnosis by molecular pathology of an early and atypical histoplasmosis lesion in the duodenum of an immunocompromised patient: A case report". Biomedical Reports 14.1 (2021): 6.
Chicago
Sumiyoshi, S., Tanaka, S., Kato, H., Takagi, K., Minamisaka, T., Noguchi, A., Nakajima, T., Imura, J."Diagnosis by molecular pathology of an early and atypical histoplasmosis lesion in the duodenum of an immunocompromised patient: A case report". Biomedical Reports 14, no. 1 (2021): 6. https://doi.org/10.3892/br.2020.1382
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