Open Access

Short‑term efficacy after switching from adefovir dipivoxil and tenofovir disoproxil fumarate therapy to tenofovir alaferamide for chronic hepatitis B

  • Authors:
    • Tomoya Sano
    • Keisuke Amano
    • Tatsuya Ide
    • Toshihiro Kawaguchi
    • Reiichiro Kuwahara
    • Teruko Arinaga‑Hino
    • Hironori Koga
    • Ryoko Kuromatsu
    • Takuji Torimura
  • View Affiliations

  • Published online on: November 12, 2020     https://doi.org/10.3892/br.2020.1388
  • Article Number: 12
  • Copyright: © Sano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the effects of switching to tenofovir alafenamide (TAF) in patients who had received a nucleos(t)ide analog (NA) for the treatment of chronic hepatitis B (CHB). The data from 33 Japanese patients with CHB who received TAF therapy after using NA [adefovir dipivoxil (ADV) and/or tenofovir disoproxil fumarate (TDF)] were retrospectively analyzed. Specifically, the biochemical and virological markers from the start of the TAF treatment to 6 months later were assessed. Comparative evaluation was performed by dividing patients into two groups: Long‑term (n=19) and short‑term administration groups (n=14), with a cutoff administration duration of 10 years. In all 33 patients, the levels of serum hepatitis B surface antigen (HBsAg; 1,126±1,724 to 1,001±1,591 IU/ml; P<0.0001), serum alkaline phosphatase (ALP) (320±126 to 283±124 U/l; P=0.028), serum bone specific alkaline phosphatase (19.7±9.0 to 17.7±8.0 µg/l; P=0.0006) and urine β2‑microglobulin‑creatinine ratio (U‑BMG/Cr; 5,224±17,471 to 3,547±14,652 µg/g·Cre; P=0.002) significantly decreased from baseline after 6 months. Serum HBsAg, serum ALP and U‑BMG/Cr showed a significant reduction in both groups. In conclusion, switching from ADV or TDF to TAF resulted in a decrease in serum HBsAg and improvement in serum ALP and U‑BMG/Cr after 6 months of treatment in patients regardless of history of treatment with NA.
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Spandidos Publications style
Sano T, Amano K, Ide T, Kawaguchi T, Kuwahara R, Arinaga‑Hino T, Koga H, Kuromatsu R and Torimura T: Short‑term efficacy after switching from adefovir dipivoxil and tenofovir disoproxil fumarate therapy to tenofovir alaferamide for chronic hepatitis&nbsp;B. Biomed Rep 14: 12, 2021
APA
Sano, T., Amano, K., Ide, T., Kawaguchi, T., Kuwahara, R., Arinaga‑Hino, T. ... Torimura, T. (2021). Short‑term efficacy after switching from adefovir dipivoxil and tenofovir disoproxil fumarate therapy to tenofovir alaferamide for chronic hepatitis&nbsp;B. Biomedical Reports, 14, 12. https://doi.org/10.3892/br.2020.1388
MLA
Sano, T., Amano, K., Ide, T., Kawaguchi, T., Kuwahara, R., Arinaga‑Hino, T., Koga, H., Kuromatsu, R., Torimura, T."Short‑term efficacy after switching from adefovir dipivoxil and tenofovir disoproxil fumarate therapy to tenofovir alaferamide for chronic hepatitis&nbsp;B". Biomedical Reports 14.1 (2021): 12.
Chicago
Sano, T., Amano, K., Ide, T., Kawaguchi, T., Kuwahara, R., Arinaga‑Hino, T., Koga, H., Kuromatsu, R., Torimura, T."Short‑term efficacy after switching from adefovir dipivoxil and tenofovir disoproxil fumarate therapy to tenofovir alaferamide for chronic hepatitis&nbsp;B". Biomedical Reports 14, no. 1 (2021): 12. https://doi.org/10.3892/br.2020.1388