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Review

Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review)

  • Authors:
    • Hideo Shigeishi
    • Masaru Sugiyama
    • Kouji Ohta
  • View Affiliations / Copyright

    Affiliations: Department of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan
  • Article Number: 40
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    Published online on: February 26, 2021
       https://doi.org/10.3892/br.2021.1416
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Abstract

Human papillomavirus (HPV) is a small DNA virus that infects the basal keratinocytes of squamous epithelium in the skin, and in the oral and genital mucosa. Smoking and sexual behavior have been recognized as significant risk factors for oral HPV infection. In the present review, the findings of recent studies of oral HPV infection in relation to periodontitis are discussed, as well as periodontopathic bacteria and periodontal herpes virus. Previous research suggests that HPV localizes to the inflammatory periodontal tissue. Inflammatory periodontal pockets may thus act as a reservoir for HPV. The interactions between HPV and periodontopathic bacteria remain unclear, but it is hypothesized that oral HPV infection may be related to a characteristic oral microbiome. Smoking is associated with HPV and periodontitis, as smoking induces destruction of periodontal tissue and suppresses the host defense, allowing HPV to infect periodontal tissue. Carcinogenic HPV and periodontitis may lead to the development of oral cavity cancer. However, oral HPV E6/E7 expression (transcriptionally active HPV) has not yet been fully investigated in patients with periodontitis. Collectively, the evidence suggests that oral HPV prevalence may be associated with periodontitis. The effect of clinical factors (age, sex, smoking, immunosuppressive condition and vaccination) on oral HPV DNA prevalence should be considered when clarifying the relationship between oral HPV and periodontitis. Additionally, the sampling method should be carefully chosen to directly detect HPV DNA in periodontal tissues.
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Spandidos Publications style
Shigeishi H, Sugiyama M and Ohta K: Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review). Biomed Rep 14: 40, 2021.
APA
Shigeishi, H., Sugiyama, M., & Ohta, K. (2021). Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review). Biomedical Reports, 14, 40. https://doi.org/10.3892/br.2021.1416
MLA
Shigeishi, H., Sugiyama, M., Ohta, K."Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review)". Biomedical Reports 14.5 (2021): 40.
Chicago
Shigeishi, H., Sugiyama, M., Ohta, K."Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review)". Biomedical Reports 14, no. 5 (2021): 40. https://doi.org/10.3892/br.2021.1416
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Spandidos Publications style
Shigeishi H, Sugiyama M and Ohta K: Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review). Biomed Rep 14: 40, 2021.
APA
Shigeishi, H., Sugiyama, M., & Ohta, K. (2021). Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review). Biomedical Reports, 14, 40. https://doi.org/10.3892/br.2021.1416
MLA
Shigeishi, H., Sugiyama, M., Ohta, K."Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review)". Biomedical Reports 14.5 (2021): 40.
Chicago
Shigeishi, H., Sugiyama, M., Ohta, K."Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review)". Biomedical Reports 14, no. 5 (2021): 40. https://doi.org/10.3892/br.2021.1416
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