Open Access

The role of HPV‑induced epigenetic changes in cervical carcinogenesis (Review)

  • Authors:
    • Martha Laysla Ramos Da Silva
    • Beatriz Helena Dantas Rodrigues De Albuquerque
    • Thales Araújo De Medeiros Fernandes Allyrio
    • Valéria Duarte De Almeida
    • Ricardo Ney De Oliveira Cobucci
    • Fabiana Lima Bezerra
    • Vania Sousa Andrade
    • Daniel Carlos Ferreira Lanza
    • Jenner Christian Veríssimo De Azevedo
    • Josélio Maria Galvão De Araújo
    • José Veríssimo Fernandes
  • View Affiliations

  • Published online on: May 20, 2021     https://doi.org/10.3892/br.2021.1436
  • Article Number: 60
  • Copyright: © Da Silva et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is associated with infection by certain types of human papillomaviruses (HPVs), and this affects women worldwide. Despite the improvements in prevention and cure of HPV‑induced cervical cancer, it remains the second most common type of cancer in women in the least developed regions of the world. Epigenetic modifications are stable long‑term changes that occur in the DNA, and are part of a natural evolutionary process of necessary adaptations to the environment. They do not result in changes in the DNA sequence, but do affect gene expression and genomic stability. Epigenetic changes are important in several biological processes. The effects of the environment on gene expression can contribute to the development of numerous diseases. Epigenetic modifications may serve a critical role in cancer cells, by silencing tumor suppressor genes, activating oncogenes, and exacerbating defects in DNA repair mechanisms. Although cervical cancer is directly related to a persistent high‑risk HPV infection, several epigenetic changes have been identified in both the viral DNA and the genome of the infected cells: DNA methylation, histone modification and gene silencing by non‑coding RNAs, which initiate and sustain epigenetic changes. In the present review, recent advances in the role of epigenetic changes in cervical cancer are summarized.
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July-2021
Volume 15 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Da Silva ML, De Albuquerque BH, Allyrio TA, De Almeida VD, Cobucci RN, Bezerra FL, Andrade VS, Lanza DC, De Azevedo JC, De Araújo JM, De Araújo JM, et al: The role of HPV‑induced epigenetic changes in cervical carcinogenesis (Review). Biomed Rep 15: 60, 2021
APA
Da Silva, M.L., De Albuquerque, B.H., Allyrio, T.A., De Almeida, V.D., Cobucci, R.N., Bezerra, F.L. ... Fernandes, J.V. (2021). The role of HPV‑induced epigenetic changes in cervical carcinogenesis (Review). Biomedical Reports, 15, 60. https://doi.org/10.3892/br.2021.1436
MLA
Da Silva, M. L., De Albuquerque, B. H., Allyrio, T. A., De Almeida, V. D., Cobucci, R. N., Bezerra, F. L., Andrade, V. S., Lanza, D. C., De Azevedo, J. C., De Araújo, J. M., Fernandes, J. V."The role of HPV‑induced epigenetic changes in cervical carcinogenesis (Review)". Biomedical Reports 15.1 (2021): 60.
Chicago
Da Silva, M. L., De Albuquerque, B. H., Allyrio, T. A., De Almeida, V. D., Cobucci, R. N., Bezerra, F. L., Andrade, V. S., Lanza, D. C., De Azevedo, J. C., De Araújo, J. M., Fernandes, J. V."The role of HPV‑induced epigenetic changes in cervical carcinogenesis (Review)". Biomedical Reports 15, no. 1 (2021): 60. https://doi.org/10.3892/br.2021.1436