Open Access

The role of immunogenic cell death in gastrointestinal cancer immunotherapy (Review)

  • Authors:
    • Worawat Songjang
    • Chatchai Nensat
    • Sutatip Pongcharoen
    • Arunya Jiraviriyakul
  • View Affiliations

  • Published online on: August 17, 2021     https://doi.org/10.3892/br.2021.1462
  • Article Number: 86
  • Copyright: © Songjang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Modern cancer immunotherapy techniques are aimed at enhancing the responses of the patients' immune systems to fight against the cancer. The main promising strategies include active vaccination of tumor antigens, passive vaccination with antibodies specific to cancer antigens, adoptive transfer of cancer‑specific T cells and manipulation of the patient's immune response by inhibiting immune checkpoints. The application of immunogenic cell death (ICD) inducers has been proven to enhance the immunity of patients undergoing various types of immunotherapy. The dying, stressed or injured cells release or present molecules on the cell surface, which function as either adjuvants or danger signals for detection by the innate immune system. These molecules are now termed ‘damage‑associated molecular patterns’. The term ‘ICD’ indicates a type of cell death that triggers an immune response against dead‑cell antigens, particularly those derived from cancer cells, and it was initially proposed with regards to the effects of anticancer chemotherapy with conventional cytotoxic drugs. The aim of the present study was to review and discuss the role and mechanisms of ICD as a promising combined immunotherapy for gastrointestinal tumors.
View Figures
View References

Related Articles

Journal Cover

October-2021
Volume 15 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Songjang W, Nensat C, Pongcharoen S and Jiraviriyakul A: The role of immunogenic cell death in gastrointestinal cancer immunotherapy (Review). Biomed Rep 15: 86, 2021
APA
Songjang, W., Nensat, C., Pongcharoen, S., & Jiraviriyakul, A. (2021). The role of immunogenic cell death in gastrointestinal cancer immunotherapy (Review). Biomedical Reports, 15, 86. https://doi.org/10.3892/br.2021.1462
MLA
Songjang, W., Nensat, C., Pongcharoen, S., Jiraviriyakul, A."The role of immunogenic cell death in gastrointestinal cancer immunotherapy (Review)". Biomedical Reports 15.4 (2021): 86.
Chicago
Songjang, W., Nensat, C., Pongcharoen, S., Jiraviriyakul, A."The role of immunogenic cell death in gastrointestinal cancer immunotherapy (Review)". Biomedical Reports 15, no. 4 (2021): 86. https://doi.org/10.3892/br.2021.1462