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Preliminary investigation of two promoter region polymorphisms of the TNFA gene in patients with recurrent depressive disorder

  • Authors:
    • Agnieszka Jeleń
    • Marta Żebrowska‑Nawrocka
    • Dagmara Szmajda‑Krygier
    • Katarzyna Mazur
    • Piotr Gałecki
    • Ewa Balcerczak
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Łódź, 90‑151 Łódź, Łódź Voivodeship, Poland, Department of Adult Psychiatry, Medical University of Łódź, 91‑229 Łódź, Łódź Voivodeship, Poland
    Copyright: © Jeleń et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 105
    |
    Published online on: October 22, 2021
       https://doi.org/10.3892/br.2021.1481
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Abstract

Immune system dysregulation plays a role in the pathogenesis of complex human diseases, including psychiatric disorders. In addition, elevated levels of pro‑inflammatory cytokines, including tumor necrosis factor α (TNF‑α) may be conditioned by the presence of specific polymorphic variants. The present case‑controlled preliminary study evaluated the prevalence of TNFA gene single nucleotide polymorphisms (SNPs) G‑308A (rs1800629) and T‑1031C (rs1799964) in 83 Polish patients with depression by restriction fragment length polymorphism analysis. The results were compared with the frequencies of genotypes in a geographically‑ and ethnically‑matched group of individuals without depression. No statistically significant difference in genotype/allele frequency was observed for either SNP between the two groups. No association was found between the particular genotypes and selected demographic/clinical features, including sex, age at diagnosis or severity of depressive symptoms before/after pharmacotherapy. Thus, there does not appear to be any connection between the studied SNPs and the development and progression of depression; however, further studies are required with larger cohorts to better understand this aspect of depression.
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Copy and paste a formatted citation
Spandidos Publications style
Jeleń A, Żebrowska‑Nawrocka M, Szmajda‑Krygier D, Mazur K, Gałecki P and Balcerczak E: Preliminary investigation of two promoter region polymorphisms of the <em>TNFA</em> gene in patients with recurrent depressive disorder. Biomed Rep 15: 105, 2021.
APA
Jeleń, A., Żebrowska‑Nawrocka, M., Szmajda‑Krygier, D., Mazur, K., Gałecki, P., & Balcerczak, E. (2021). Preliminary investigation of two promoter region polymorphisms of the <em>TNFA</em> gene in patients with recurrent depressive disorder. Biomedical Reports, 15, 105. https://doi.org/10.3892/br.2021.1481
MLA
Jeleń, A., Żebrowska‑Nawrocka, M., Szmajda‑Krygier, D., Mazur, K., Gałecki, P., Balcerczak, E."Preliminary investigation of two promoter region polymorphisms of the <em>TNFA</em> gene in patients with recurrent depressive disorder". Biomedical Reports 15.6 (2021): 105.
Chicago
Jeleń, A., Żebrowska‑Nawrocka, M., Szmajda‑Krygier, D., Mazur, K., Gałecki, P., Balcerczak, E."Preliminary investigation of two promoter region polymorphisms of the <em>TNFA</em> gene in patients with recurrent depressive disorder". Biomedical Reports 15, no. 6 (2021): 105. https://doi.org/10.3892/br.2021.1481
Copy and paste a formatted citation
x
Spandidos Publications style
Jeleń A, Żebrowska‑Nawrocka M, Szmajda‑Krygier D, Mazur K, Gałecki P and Balcerczak E: Preliminary investigation of two promoter region polymorphisms of the <em>TNFA</em> gene in patients with recurrent depressive disorder. Biomed Rep 15: 105, 2021.
APA
Jeleń, A., Żebrowska‑Nawrocka, M., Szmajda‑Krygier, D., Mazur, K., Gałecki, P., & Balcerczak, E. (2021). Preliminary investigation of two promoter region polymorphisms of the <em>TNFA</em> gene in patients with recurrent depressive disorder. Biomedical Reports, 15, 105. https://doi.org/10.3892/br.2021.1481
MLA
Jeleń, A., Żebrowska‑Nawrocka, M., Szmajda‑Krygier, D., Mazur, K., Gałecki, P., Balcerczak, E."Preliminary investigation of two promoter region polymorphisms of the <em>TNFA</em> gene in patients with recurrent depressive disorder". Biomedical Reports 15.6 (2021): 105.
Chicago
Jeleń, A., Żebrowska‑Nawrocka, M., Szmajda‑Krygier, D., Mazur, K., Gałecki, P., Balcerczak, E."Preliminary investigation of two promoter region polymorphisms of the <em>TNFA</em> gene in patients with recurrent depressive disorder". Biomedical Reports 15, no. 6 (2021): 105. https://doi.org/10.3892/br.2021.1481
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