Preliminary investigation of two promoter region polymorphisms of the <em>TNFA</em> gene in patients with recurrent depressive disorder

Jeleń,Agnieszka; Żebrowska‑Nawrocka,Marta; Szmajda‑Krygier,Dagmara; Mazur,Katarzyna; Gałecki,Piotr; Balcerczak,Ewa

doi:10.3892/br.2021.1481

Preliminary investigation of two promoter region polymorphisms of the TNFA gene in patients with recurrent depressive disorder

Authors:
- Agnieszka Jeleń
- Marta Żebrowska‑Nawrocka
- Dagmara Szmajda‑Krygier
- Katarzyna Mazur
- Piotr Gałecki
- Ewa Balcerczak
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Affiliations: Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Łódź, 90‑151 Łódź, Łódź Voivodeship, Poland, Department of Adult Psychiatry, Medical University of Łódź, 91‑229 Łódź, Łódź Voivodeship, Poland
Published online on: October 22, 2021 https://doi.org/10.3892/br.2021.1481
Article Number: 105
Copyright: © Jeleń et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immune system dysregulation plays a role in the pathogenesis of complex human diseases, including psychiatric disorders. In addition, elevated levels of pro‑inflammatory cytokines, including tumor necrosis factor α (TNF‑α) may be conditioned by the presence of specific polymorphic variants. The present case‑controlled preliminary study evaluated the prevalence of TNFA gene single nucleotide polymorphisms (SNPs) G‑308A (rs1800629) and T‑1031C (rs1799964) in 83 Polish patients with depression by restriction fragment length polymorphism analysis. The results were compared with the frequencies of genotypes in a geographically‑ and ethnically‑matched group of individuals without depression. No statistically significant difference in genotype/allele frequency was observed for either SNP between the two groups. No association was found between the particular genotypes and selected demographic/clinical features, including sex, age at diagnosis or severity of depressive symptoms before/after pharmacotherapy. Thus, there does not appear to be any connection between the studied SNPs and the development and progression of depression; however, further studies are required with larger cohorts to better understand this aspect of depression.

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1	Jeleń A, Sałagacka A and Balcerczak E: Characterisation of selected molecular mechanisms influencing pharmacokinetics and pharmacodynamics of antidepressants. Postepy Hig Med Dosw. 69:753–762. 2015.PubMed/NCBI View Article : Google Scholar : (In Polish).
2	Farooq RK, Asghar K, Kanwal S and Zulqernain A: Role of inflammatory cytokines in depression: Focus on interleukin-1β. Biomed Rep. 6:15–20. 2017.PubMed/NCBI View Article : Google Scholar
3	Miller AH, Maletic V and Raison CL: Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 65:732–741. 2009.PubMed/NCBI View Article : Google Scholar
4	Decourt B, Lahiri DK and Sabbagh MN: Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease. Curr Alzheimer Res. 14:412–425. 2017.PubMed/NCBI View Article : Google Scholar
5	Cervellati C, Trentini A, Pecorelli A and Valacchi G: Inflammation in neurological disorders: The thin boundary between brain and periphery. Antioxid Redox Signal. 33:191–210. 2020.PubMed/NCBI View Article : Google Scholar
6	Pajares M, I Rojo A, Manda G, Boscá L and Cuadrado A: Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications. Cells. 9(1687)2020.PubMed/NCBI View Article : Google Scholar
7	Idda ML, Munk R, Abdelmohsen K and Gorospe M: Noncoding RNAs in Alzheimer's disease. Wiley Interdiscip Rev RNA. 9(c1463)2018.PubMed/NCBI View Article : Google Scholar
8	O'Meara T, Kong Y, Chiarella J, Price RW, Chaudhury R, Liu X, Spudich S, Robertson K, Emu B and Lu L: Exosomal MicroRNAs Associate With Neuropsychological Performance in Individuals With HIV Infection on Antiretroviral Therapy. J Acquir Immune Defic Syndr. 82:514–522. 2019.PubMed/NCBI View Article : Google Scholar
9	El-Tahan RR, Ghoneim AM and El-Mashad N: TNF-α gene polymorphisms and expression. Springerplus. 5(1508)2016.PubMed/NCBI View Article : Google Scholar
10	Yi F, Shi X, Pei X and Wu X: Tumor necrosis factor-alpha-308 gene promoter polymorphism associates with survival of cancer patients: A meta-analysis. Medicine (Baltimore). 97(e13160)2018.PubMed/NCBI View Article : Google Scholar
11	Huang R, Zhao SR, Li Y, Liu F, Gong Y, Xing J and Xu ZS: Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: A systematic review and meta-analysis. BMC Med Genet. 21(29)2020.PubMed/NCBI View Article : Google Scholar
12	Qidwai T and Khan F: Tumour necrosis factor gene polymorphism and disease prevalence. Scand J Immunol. 74:522–547. 2011.PubMed/NCBI View Article : Google Scholar
13	World Health Organization (WHO): The ICD-10 Classification of Mental and Behavioural Disorders. World Health Organization, Geneva, 1993.
14	Patten SB: Performance of the Composite International Diagnostic Interview Short Form for major depression in community and clinical samples. Chronic Dis Can. 18:109–112. 1997.PubMed/NCBI
15	World Medical Association. World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA. 310:2191–2194. 2013.PubMed/NCBI View Article : Google Scholar
16	Bednarczuk T, Hiromatsu Y, Seki N, Płoski R, Fukutani T, Kuryłowicz A, Jazdzewski K, Chojnowski K, Itoh K and Nauman J: Association of tumor necrosis factor and human leukocyte antigen DRB1 alleles with Graves' ophthalmopathy. Hum Immunol. 65:632–639. 2004.PubMed/NCBI View Article : Google Scholar
17	Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK and Lanctôt KL: A meta-analysis of cytokines in major depression. Biol Psychiatry. 67:446–457. 2010.PubMed/NCBI View Article : Google Scholar
18	Jun TY, Pae CU, Hoon-Han Chae JH, Bahk WM, Kim KS and Serretti A: Possible association between -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population. Psychiatr Genet. 13:179–181. 2003.PubMed/NCBI View Article : Google Scholar
19	Barnes J, Mondelli V and Pariante CM: Genetic Contributions of Inflammation to Depression. Neuropsychopharmacology. 42:81–98. 2017.PubMed/NCBI View Article : Google Scholar
20	Mihailova S, Ivanova-Genova E, Lukanov T, Stoyanova V, Milanova V and Naumova E: A study of TNF-α, TGF-β, IL-10, IL-6, and IFN-γ gene polymorphisms in patients with depression. J Neuroimmunol. 293:123–128. 2016.PubMed/NCBI View Article : Google Scholar
21	Haastrup E, Bukh JD, Bock C, Vinberg M, Thørner LW, Hansen T, Werge T, Kessing LV and Ullum H: Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events. J Affect Disord. 136:134–138. 2012.PubMed/NCBI View Article : Google Scholar
22	Lezheiko TV, Andryushchenko AV, Korovaitseva GI, Kondratiev NV, Gabaeva MV, Krikova EV and Golimbet VE: Association of Genes for Proinflammatory Cytokines and Depression. Neurosci Behav Physiol. 49:749–753. 2019.
23	Shin KH, Jeong HC, Choi DH, Kim SN and Kim TE: Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis. Neuropsychiatr Dis Treat. 13:2661–2668. 2017.PubMed/NCBI View Article : Google Scholar
24	Wang X, Zhang H, Cao X, Shi W, Zhou X, Chen Q and Ma K: Gene-disease association study of tumor necrosis factor-α G-308A gene polymorphism with risk of major depressive disorder: A systematic review and meta-analysis. Brain Behav. 10(e01628)2020.PubMed/NCBI View Article : Google Scholar
25	Trujillo-Murillo K, Pérez-Ibave D, Muñoz-Mejía C, Cordero-Pérez P, Muñoz-Espinosa L, Martínez-Rodríguez H, Bosques-Padilla F and Rivas-Estilla AM: Prevalence of the -308 and -238 tumor necrosis factor alpha (TNF-α) promoter polymorphisms in Mexican chronic hepatitis C patients. Rev Gastroenterol Mex. 75:7–11. 2010.PubMed/NCBI
26	Ma K, Zhang H and Baloch Z: Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-α (TNF-α) in Major Depressive Disorder: A Systematic Review. Int J Mol Sci. 17(733)2016.PubMed/NCBI View Article : Google Scholar
27	Misener VL, Gomez L, Wigg KG, Luca P, King N, Kiss E, Daróczi G, Kapornai K, Tamas Z, Mayer L, et al: International Consortium for Childhood-Onset Mood Disorders: Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders. Neuropsychobiology. 58:71–80. 2008.PubMed/NCBI View Article : Google Scholar
28	Bialek K, Czarny P, Watala C, Synowiec E, Wigner P, Bijak M, Talarowska M, Galecki P, Szemraj J and Sliwinski T: Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder. Cell Mol Neurobiol. 40:1049–1056. 2020.PubMed/NCBI View Article : Google Scholar