Open Access

Mitochondria‑related TFAM gene variants and their effects on patients with cervical cancer

  • Authors:
    • Ieva Golubickaite
    • Rasa Ugenskiene
    • Juste Cepaite
    • Egle Ziliene
    • Arturas Inciura
    • Lina Poskiene
    • Elona Juozaityte
  • View Affiliations

  • Published online on: October 28, 2021     https://doi.org/10.3892/br.2021.1482
  • Article Number: 106
  • Copyright: © Golubickaite et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is the fourth most common type of cancer in women worldwide, with high incidence and mortality rates, particularly in developing countries. There are human papillomavirus vaccines and cytological screening programs available; however, there are no molecular markers that would aid the prognosis of the course of the disease or prediction of the outcomes of the patients. The aim of the present study was to investigate the associations between single nucleotide polymorphisms (SNPs) of the mitochondrial transcription factor A (TFAM) gene (rs11006132, rs11006129, rs1937, rs16912174, rs16912202 and rs3900887), and the clinical parameters and tumor phenotype of patients with cervical cancer. DNA isolated from patients with cervical cancer (n=172) was used for genotyping using Real‑Time PCR using TaqMan probes. It was revealed that the TFAM rs3900887 TT and AT genotypes were associated with a lower risk of developing larger tumors. The results showed an association between the rs3900887 SNP and tumor phenotype, indicating TFAM rs3900887 as a potential biomarker for tumor size in cervical cancer.
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December-2021
Volume 15 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Golubickaite I, Ugenskiene R, Cepaite J, Ziliene E, Inciura A, Poskiene L and Juozaityte E: Mitochondria‑related TFAM gene variants and their effects on patients with cervical cancer. Biomed Rep 15: 106, 2021
APA
Golubickaite, I., Ugenskiene, R., Cepaite, J., Ziliene, E., Inciura, A., Poskiene, L., & Juozaityte, E. (2021). Mitochondria‑related TFAM gene variants and their effects on patients with cervical cancer. Biomedical Reports, 15, 106. https://doi.org/10.3892/br.2021.1482
MLA
Golubickaite, I., Ugenskiene, R., Cepaite, J., Ziliene, E., Inciura, A., Poskiene, L., Juozaityte, E."Mitochondria‑related TFAM gene variants and their effects on patients with cervical cancer". Biomedical Reports 15.6 (2021): 106.
Chicago
Golubickaite, I., Ugenskiene, R., Cepaite, J., Ziliene, E., Inciura, A., Poskiene, L., Juozaityte, E."Mitochondria‑related TFAM gene variants and their effects on patients with cervical cancer". Biomedical Reports 15, no. 6 (2021): 106. https://doi.org/10.3892/br.2021.1482