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The impact of single‑nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct‑acting antiviral drugs for hepatitis C infection

  • Authors:
    • Kosuke Matsumoto
    • Hisamitsu Miyaaki
    • Masanori Fukushima
    • Ryu Sasaki
    • Masafumi Haraguchi
    • Satoshi Miuma
    • Kazuhiko Nakao
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8501, Japan
    Copyright: © Matsumoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 9
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    Published online on: December 7, 2021
       https://doi.org/10.3892/br.2021.1492
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Abstract

Single‑nucleotide polymorphisms (SNPs) of patatin‑like phospholipase domain‑containing 3 (PNPLA3), tolloid‑like protein 1 (TLL1) and interleukin‑28 (IL28) have been identified as susceptibility factors for liver steatosis, inflammation and fibrosis in patients with hepatitis C virus (HCV) infection. Here, whether these polymorphisms affected predispositions to changes in liver stiffness (LS) and controlled attenuation parameter (CAP) following direct‑acting antiviral (DAA) therapy was assessed. The changes in LS and steatosis in 77 HCV‑infected patients receiving DAA therapy were compared with PNPLA3, TLL1 and IL28 genotypes, using CAP, FibroScan and Virtual Touch tissue quantification (VTTQ) before treatment and 12 weeks after the end of the treatment. VTTQ results showed that LS significantly decreased in PNPLA3 CC (P=0.035), TLL1 AA (P=0.011) and IL28B TT (P=0.005) genotypes; no significant differences were observed in PNPLA3 CG/GG, TLL1 AT/TT and IL28B TG/GG. FibroScan results showed that LS significantly decreased in TLL1 AA (P=0.028) and IL28B TT (P=0.032), with no significant difference in PNPLA3 CC. No significant differences were observed in PNPLA3 CG/GG, TLL1 AT/TT and IL28B TG/GG groups. CAP was significantly increased in PNPLA3 CG/GG (P=0.039 and P<0.05) and IL28B TT (P=0.014); no significant difference was observed in PNPLA3 CC and all genotypes of TLL1 and IL28B TG/GG. Therefore, these results indicated that SNPs could predict changes in LS and steatosis after DAA therapy.
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1 

Li R, Li Y, Fang X, Yang H and Wang J, Kristiansen K and Wang J: SNP detection for massively parallel whole-genome resequencing. Genome Res. 19:1124–1132. 2009.PubMed/NCBI View Article : Google Scholar

2 

Sato M, Kato N, Tateishi R, Muroyama R, Kowatari N, Li W, Goto K, Otsuka M, Shiina S, Yoshida H, et al: Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Hepatol Res. 44:E137–E144. 2014.PubMed/NCBI View Article : Google Scholar

3 

Yasui K, Kawaguchi T, Shima T, Mitsuyoshi H, Seki K, Sendo R, Mizuno M, Itoh Y, Matsuda F and Okanoue T: Effect of PNPLA3 rs738409 variant (I148 M) on hepatic steatosis, necroinflammation, and fibrosis in Japanese patients with chronic hepatitis C. J Gastroenterol. 50:887–893. 2015.PubMed/NCBI View Article : Google Scholar

4 

Crisan D, Grigorescu M, Crisan N, Craciun R, Lupsor M, Radu C, Grigorescu MD, Suciu A, Epure F, Avram L and Leach N: Association between PNPLA3[G]/I148M variant, steatosis and fibrosis stage in hepatitis C virus-genetic matters. J Physiol Pharmacol. 70:2019.PubMed/NCBI View Article : Google Scholar

5 

Matsuura K, Sawai H, Ikeo K, Ogawa S, Iio E, Isogawa M, Shimada N, Komori A, Toyoda H, Kumada T, et al: Genome-wide association study identifies TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus infection. Gastroenterology. 152:1383–1394. 2017.PubMed/NCBI View Article : Google Scholar

6 

Huang CF, Yeh ML, Huang CI, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL, Chen JJ and Yu ML: Tolloid-like 1 genetic variants determine fibrosis regression in chronic hepatitis C patients with curative antivirals. Sci Rep. 8(15058)2018.PubMed/NCBI View Article : Google Scholar

7 

Iio E, Matsuura K, Shimada N, Atsukawa M, Itokawa N, Abe H, Kato K, Takaguchi K, Senoh T, Eguchi Y, et al: TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus by interferon-free therapy. J Gastroenterol. 54:339–346. 2019.PubMed/NCBI View Article : Google Scholar

8 

Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, et al: Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients. J Hepatol. 53:439–443. 2010.PubMed/NCBI View Article : Google Scholar

9 

Bochud PY, Bibert S, Negro F, Haagmans B, Soulier A, Ferrari C, Missale G, Zeuzem S, Pawlotsky JM, Schalm S, et al: IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C. J Hepatol. 55:980–988. 2011.PubMed/NCBI View Article : Google Scholar

10 

Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, et al: Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. J Hepatol. 54:439–448. 2011.PubMed/NCBI View Article : Google Scholar

11 

Ohnishi M, Tsuge M, Kohno T, Zhang Y, Abe H, Hyogo H, Kimura Y, Miki D, Hiraga N, Imamura M, et al: IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients. J Gastroenterol. 47:834–844. 2012.PubMed/NCBI View Article : Google Scholar

12 

Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, et al: Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C. J Gastroenterol. 49:1152–1162. 2014.PubMed/NCBI View Article : Google Scholar

13 

Sato M, Kondo M, Tateishi R, Fujiwara N, Kato N, Yoshida H, Taguri M and Koike K: Impact of IL28B genetic variation on HCV-induced liver fibrosis, inflammation, and steatosis: A meta-analysis. PLoS One. 9(e91822)2014.PubMed/NCBI View Article : Google Scholar

14 

Tamaki N, Kurosaki M, Higuchi M, Takada H, Nakakuki N, Yasui Y, Suzuki S, Tsuchiya K, Nakanishi H, Itakura J, et al: Genetic polymorphisms of IL28B and PNPLA3 are predictive for HCV related rapid fibrosis progression and identify patients who require urgent antiviral treatment with new regimens. PLoS One. 10(e0137351)2015.PubMed/NCBI View Article : Google Scholar

15 

Myers RP, Fong A and Shaheen AA: Utilization rates, complications and costs of percutaneous liver biopsy: A population-based study including 4275 biopsies. Liver Int. 28:705–712. 2008.PubMed/NCBI View Article : Google Scholar

16 

Sasso M, Beaugrand M, de Ledinghen V, Douvin C, Marcellin P, Poupon R, Sandrin L and Miette V: Controlled attenuation parameter (CAP): A novel VCTE™ guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: Preliminary study and validation in a cohort of patients with chronic liver disease from various causes. Ultrasound Med Biol. 36:1825–1835. 2010.PubMed/NCBI View Article : Google Scholar

17 

Petruzziello A, Marigliano S, Loquercio G, Cozzolino A and Cacciapuoti C: Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol. 22:7824–7840. 2016.PubMed/NCBI View Article : Google Scholar

18 

Attar BM and Van Thiel DH: Hepatitis C virus: A time for decisions. Who should be treated and when? World J Gastrointest Pharmacol Ther. 7:33–40. 2016.PubMed/NCBI View Article : Google Scholar

19 

Leroy V, Angus P, Bronowicki JP, Dore GJ, Hezode C, Pianko S, Pol S, Stuart K, Tse E, McPhee F, et al: Daclatasvir, sofosbuvir, and ribavirin for hepatitis C virus genotype 3 and advanced liver disease: A randomized phase III study (ALLY-3+). Hepatology. 63:1430–1441. 2016.PubMed/NCBI View Article : Google Scholar

20 

Ogasawara N, Kobayashi M, Akuta N, Kominami Y, Fujiyama S, Kawamura Y, Sezaki H, Hosaka T, Suzuki F, Saitoh S, et al: Serial changes in liver stiffness and controlled attenuation parameter following direct-acting antiviral therapy against hepatitis C virus genotype 1b. J Med Virol. 90:313–319. 2018.PubMed/NCBI View Article : Google Scholar

21 

World Medical Association: World medical association declaration of Helsinki. Ethical principles for medical research involving human subjects. JAMA. 310:2191–2194. 2013.PubMed/NCBI View Article : Google Scholar

22 

Bamber J, Cosgrove D, Dietrich CF, Fromageau J, Bojunga J, Calliada F, Cantisani V, Correas JM, D'Onofrio M, Drakonaki EE, et al: EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 1: Basic principles and technology. Ultraschall Med. 34:169–184. 2013.PubMed/NCBI View Article : Google Scholar

23 

Boursier J, Zarski JP, de Ledinghen V, Rousselet MC, Sturm N, Lebail B, Fouchard-Hubert I, Gallois Y, Oberti F, Bertrais S, et al: Determination of reliability criteria for liver stiffness evaluation by transient elastography. Hepatology. 57:1182–1191. 2013.PubMed/NCBI View Article : Google Scholar

24 

Kumagai E, Korenaga K, Korenaga M, Imamura M, Ueyama M, Aoki Y, Sugiyama M, Murata K, Masaki N, Kanto T, et al: Appropriate use of virtual touch quantification and FibroScan M and XL probes according to the skin capsular distance. J Gastroenterol. 51:496–505. 2016.PubMed/NCBI View Article : Google Scholar

25 

De la Vega FM, Lazaruk KD, Rhodes MD and Wenz MH: Assessment of two flexible and compatible SNP genotyping platforms: TaqMan SNP genotyping assays and the SNPlex genotyping system. Mutat Res. 573:111–135. 2005.PubMed/NCBI View Article : Google Scholar

26 

Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, Boerwinkle E, Cohen JC and Hobbs HH: Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 40:1461–1465. 2008.PubMed/NCBI View Article : Google Scholar

27 

Seko Y, Sumida Y, Tanaka S, Mori K, Taketani H, Ishiba H, Hara T, Okajima A, Umemura A, Nishikawa T, et al: Development of hepatocellular carcinoma in Japanese patients with biopsy-proven non-alcoholic fatty liver disease: Association between PNPLA3 genotype and hepatocarcinogenesis/fibrosis progression. Hepatol Res. 47:1083–1092. 2017.PubMed/NCBI View Article : Google Scholar

28 

Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, et al: Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet. 41:1105–1109. 2009.PubMed/NCBI View Article : Google Scholar

29 

Morgan TR, Ghany MG, Kim HY, Snow KK, Shiffman ML, De Santo JL, Lee WM, Di Bisceglie AM, Bonkovsky HL, Dienstag JL, et al: Outcome of sustained virological responders with histologically advanced chronic hepatitis C. Hepatology. 52:833–844. 2010.PubMed/NCBI View Article : Google Scholar

30 

Kanwal F, Kramer J, Asch SM, Chayanupatkul M, Cao Y and El-Serag HB: Risk of hepatocellular cancer in HCV patients treated with direct-acting antiviral agents. Gastroenterology. 153:996–1005.e1. 2017.PubMed/NCBI View Article : Google Scholar

31 

Ogata F, Kobayashi M, Akuta N, Osawa M, Fujiyama S, Kawamura Y, Sezaki H, Hosaka T, Kobayashi M, Saitoh S, et al: Outcome of all-oral direct-acting antiviral regimens on the rate of development of hepatocellular carcinoma in patients with hepatitis C virus genotype 1-related chronic liver disease. Oncology. 93:92–98. 2017.PubMed/NCBI View Article : Google Scholar

32 

Makiyama A, Itoh Y, Kasahara A, Imai Y, Kawata S, Yoshioka K, Tsubouchi H, Kiyosawa K, Kakumu S, Okita K, et al: Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy. Cancer. 101:1616–1622. 2004.PubMed/NCBI View Article : Google Scholar

33 

Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, et al: α-Fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C. Hepatology. 58:1253–1262. 2013.PubMed/NCBI View Article : Google Scholar

34 

El-Serag HB, Kanwal F, Richardson P and Kramer J: Risk of hepatocellular carcinoma after sustained virological response in Veterans with hepatitis C virus infection. Hepatology. 64:130–137. 2016.PubMed/NCBI View Article : Google Scholar

35 

Ioannou GN, Green PK, Beste LA, Mun EJ, Kerr KF and Berry K: Development of models estimating the risk of hepatocellular carcinoma after antiviral treatment for hepatitis C. J Hepatol. 69:1088–1098. 2018.PubMed/NCBI View Article : Google Scholar

36 

Motoyama H, Tamori A, Kubo S, Uchida-Kobayashi S, Takemura S, Tanaka S, Ohfuji S, Teranishi Y, Kozuka R, Kawamura E, et al: Stagnation of histopathological improvement is a predictor of hepatocellular carcinoma development after hepatitis C virus eradication. PLoS One. 13(e0194163)2018.PubMed/NCBI View Article : Google Scholar

37 

Tanaka A, Uegaki S, Kurihara H, Aida K, Mikami M, Nagashima I, Shiga J and Takikawa H: Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C. World J Gastroenterol. 13:5180–5187. 2007.PubMed/NCBI View Article : Google Scholar

38 

Myers RP, Pomier-Layrargues G, Kirsch R, Pollett A, Duarte-Rojo A, Wong D, Beaton M, Levstik M, Crotty P and Elkashab M: Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients. Hepatology. 55:199–208. 2012.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Matsumoto K, Miyaaki H, Fukushima M, Sasaki R, Haraguchi M, Miuma S and Nakao K: The impact of single‑nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct‑acting antiviral drugs for hepatitis C infection. Biomed Rep 16: 9, 2022.
APA
Matsumoto, K., Miyaaki, H., Fukushima, M., Sasaki, R., Haraguchi, M., Miuma, S., & Nakao, K. (2022). The impact of single‑nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct‑acting antiviral drugs for hepatitis C infection. Biomedical Reports, 16, 9. https://doi.org/10.3892/br.2021.1492
MLA
Matsumoto, K., Miyaaki, H., Fukushima, M., Sasaki, R., Haraguchi, M., Miuma, S., Nakao, K."The impact of single‑nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct‑acting antiviral drugs for hepatitis C infection". Biomedical Reports 16.2 (2022): 9.
Chicago
Matsumoto, K., Miyaaki, H., Fukushima, M., Sasaki, R., Haraguchi, M., Miuma, S., Nakao, K."The impact of single‑nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct‑acting antiviral drugs for hepatitis C infection". Biomedical Reports 16, no. 2 (2022): 9. https://doi.org/10.3892/br.2021.1492
Copy and paste a formatted citation
x
Spandidos Publications style
Matsumoto K, Miyaaki H, Fukushima M, Sasaki R, Haraguchi M, Miuma S and Nakao K: The impact of single‑nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct‑acting antiviral drugs for hepatitis C infection. Biomed Rep 16: 9, 2022.
APA
Matsumoto, K., Miyaaki, H., Fukushima, M., Sasaki, R., Haraguchi, M., Miuma, S., & Nakao, K. (2022). The impact of single‑nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct‑acting antiviral drugs for hepatitis C infection. Biomedical Reports, 16, 9. https://doi.org/10.3892/br.2021.1492
MLA
Matsumoto, K., Miyaaki, H., Fukushima, M., Sasaki, R., Haraguchi, M., Miuma, S., Nakao, K."The impact of single‑nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct‑acting antiviral drugs for hepatitis C infection". Biomedical Reports 16.2 (2022): 9.
Chicago
Matsumoto, K., Miyaaki, H., Fukushima, M., Sasaki, R., Haraguchi, M., Miuma, S., Nakao, K."The impact of single‑nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct‑acting antiviral drugs for hepatitis C infection". Biomedical Reports 16, no. 2 (2022): 9. https://doi.org/10.3892/br.2021.1492
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