Open Access

Effects of swimming training on myocardial protection in rats

  • Authors:
    • Chang-Chi Lai
    • Chia-Yu Tang
    • Szu-Kai Fu
    • Wei-Chin Tseng
    • Kuo-Wei Tseng
  • View Affiliations

  • Published online on: January 31, 2022     https://doi.org/10.3892/br.2022.1502
  • Article Number: 19
  • Copyright: © Lai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Swimming is important for promoting and maintaining health, as it can increase the efficiency of the cardiovascular system and decrease the occurrence of cardiovascular diseases. The objective of the present study was to examine whether swimming training could decrease myocardial injury in rats caused by myocardial ischemia/reperfusion (I/R). Sprague‑Dawley rats were randomized into four groups, namely the Sham, coronary artery occlusion, swimming training and ischemic preconditioning (IPC) groups. Myocardial I/R was induced in anesthetized male Sprague‑Dawley rats by a 40‑min occlusion followed by a 3‑h reperfusion of the left anterior descending coronary artery. The rats were sacrificed after surgery and their hearts were examined. The results demonstrated that the number of TUNEL‑positive nuclei and degree of caspase‑3 activation were both significantly increased in the myocardium following myocardial I/R in rats, indicating increased cardiomyocyte apoptosis. On the other hand, swimming training decreased the serum levels of creatine phosphokinase, lactate dehydrogenase and cardiac troponin I, and was associated with reduced histological damage and myocardial infarct size. Furthermore, swimming training also reduced TNF‑α levels, caspase‑3 activation and enhanced Bcl‑2 activation, which decreased the number of apoptotic cells in the myocardium. The findings of the present study showed that swimming training and IPC could similarly decrease myocardial injury following myocardial I/R, and may therefore be used as exercise training to effectively prevent myocardial injury.
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March-2022
Volume 16 Issue 3

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Spandidos Publications style
Lai C, Tang C, Fu S, Tseng W and Tseng K: Effects of swimming training on myocardial protection in rats. Biomed Rep 16: 19, 2022
APA
Lai, C., Tang, C., Fu, S., Tseng, W., & Tseng, K. (2022). Effects of swimming training on myocardial protection in rats. Biomedical Reports, 16, 19. https://doi.org/10.3892/br.2022.1502
MLA
Lai, C., Tang, C., Fu, S., Tseng, W., Tseng, K."Effects of swimming training on myocardial protection in rats". Biomedical Reports 16.3 (2022): 19.
Chicago
Lai, C., Tang, C., Fu, S., Tseng, W., Tseng, K."Effects of swimming training on myocardial protection in rats". Biomedical Reports 16, no. 3 (2022): 19. https://doi.org/10.3892/br.2022.1502