Open Access

Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer's disease, cerebral ischemia and multiple sclerosis (Review)

  • Authors:
    • Johanna Andrea Gutiérrez‑Vargas
    • John Fredy Castro‑Álvarez
    • Jose Fernando Zapata‑Berruecos
    • Komal Abdul‑Rahim
    • Anibal Arteaga‑Noriega
  • View Affiliations

  • Published online on: February 18, 2022     https://doi.org/10.3892/br.2022.1510
  • Article Number: 27
  • Copyright: © Gutiérrez‑Vargas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The cytoskeleton is the main intracellular structure that determines the morphology of neurons and maintains their integrity. Therefore, disruption of its structure and function may underlie several neurodegenerative diseases. This review summarizes the current literature on the tau protein, microtubule‑associated protein 2 (MAP2) and neurofilaments as common denominators in pathological conditions such as Alzheimer's disease (AD), cerebral ischemia, and multiple sclerosis (MS). Insights obtained from experimental models using biochemical and immunocytochemical techniques highlight that changes in these proteins may be potentially used as protein targets in clinical settings, which provides novel opportunities for the detection, monitoring and treatment of patients with these neurodegenerative diseases.
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April-2022
Volume 16 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Gutiérrez‑Vargas JA, Castro‑Álvarez JF, Zapata‑Berruecos JF, Abdul‑Rahim K and Arteaga‑Noriega A: Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer's disease, cerebral ischemia and multiple sclerosis (Review). Biomed Rep 16: 27, 2022
APA
Gutiérrez‑Vargas, J.A., Castro‑Álvarez, J.F., Zapata‑Berruecos, J.F., Abdul‑Rahim, K., & Arteaga‑Noriega, A. (2022). Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer's disease, cerebral ischemia and multiple sclerosis (Review). Biomedical Reports, 16, 27. https://doi.org/10.3892/br.2022.1510
MLA
Gutiérrez‑Vargas, J. A., Castro‑Álvarez, J. F., Zapata‑Berruecos, J. F., Abdul‑Rahim, K., Arteaga‑Noriega, A."Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer's disease, cerebral ischemia and multiple sclerosis (Review)". Biomedical Reports 16.4 (2022): 27.
Chicago
Gutiérrez‑Vargas, J. A., Castro‑Álvarez, J. F., Zapata‑Berruecos, J. F., Abdul‑Rahim, K., Arteaga‑Noriega, A."Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer's disease, cerebral ischemia and multiple sclerosis (Review)". Biomedical Reports 16, no. 4 (2022): 27. https://doi.org/10.3892/br.2022.1510