Lotus essential oil improves neurite elongation and facilitates functional recovery after peripheral nerve injury

Sriraksa,Napatr; Kongsui,Ratchaniporn; Thongrong,Sitthisak

doi:10.3892/br.2022.1513

Lotus essential oil improves neurite elongation and facilitates functional recovery after peripheral nerve injury

Authors:
- Napatr Sriraksa
- Ratchaniporn Kongsui
- Sitthisak Thongrong
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Affiliations: Division of Physiology, School of Medical Sciences, University of Phayao, Amphur Muang, Phayao 56000, Thailand, The Unit of Excellence in Translational Neurosciences Initiative, University of Phayao, Amphur Muang, Phayao 56000, Thailand
Published online on: February 18, 2022 https://doi.org/10.3892/br.2022.1513
Article Number: 30
Copyright: © Sriraksa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Injury to the peripheral nerve may lead to deficits in nerve function. An increase in the levels of free radicals plays a role in inhibition of nerve regeneration following damage. The aim of this study was to investigate the effects of lotus essential oil (LEO) on neurite outgrowth in vitro and nerve regeneration in vivo in a rat model of sciatic nerve crush injury. Gas chromatography‑mass spectrometry analysis showed that the principal constituent of LEO was palmitic acid ethyl ester (25.12%). The radical scavenging activity of LEO was evaluated using the DPPH method, and was determined to be IC₅₀=29.01±2.93 µg/ml. LEO‑treated sensory neurons exhibited increased neurite outgrowth and upregulated levels of phospho‑ERK. Sensory and motor functions were improved in rats treated with 50 and 100 mg/kg LEO, and this was accompanied by an increase in the number of neurons in the dorsal root ganglia, as well as an increase in the nerve axon diameters following nerve injury. Taken together, these results suggests that LEO may serve as a novel pharmacological option for the management of peripheral nerve injury.

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