Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-2022 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2022 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of curcumin and γ‑oryzanol solid dispersion on the brain of middle‑aged rats

  • Authors:
    • Thanyaphon Phothi
    • Sakara Tunsophon
    • Waree Tiyaboonchai
    • Onrawee Khongsombat
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand
    Copyright: © Phothi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 59
    |
    Published online on: May 26, 2022
       https://doi.org/10.3892/br.2022.1542
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oxidative stress is one of the major factors that contributes to brain deterioration in the elderly. Oxidation causes molecular alterations, structural damage, and brain dysfunction, which includes cognitive impairment. Memory loss can begin in middle‑aged individuals, so prevention of brain deterioration before aging is important. Several studies have reported that curcumin and γ‑oryzanol exhibits anti‑oxidant and anti‑inflammatory properties. However, curcumin and γ‑oryzanol exhibit low aqueous solubility. Thus, a solid dispersion technique was used to prepare curcumin and γ‑oryzanol to enhance their solubility and stability. This study aims to evaluate the effects and mechanisms of γ‑oryzanol solid dispersion (GOSD) and curcumin solid dispersion (CURSD) on learning and memory in six groups of male rats (n=5/group). Group one was the adult control consisting of 6‑week old male rats, and the remaining five groups consisted of 42‑week (middle‑aged) male rats. The groups were labeled as the control group, the GO group (GOSD 10 mg/kg·BW), the Cur group (CURSD 50 mg/kg·BW), the GO‑LCur group (GOSD 10 mg/kg·BW plus CURSD 25 mg/kg·BW), and the GO‑HCur group (GOSD 10 mg/kg·BW plus CURSD 50 mg/kg·BW). Substances were administrated by oral gavage once daily for 42 consecutive days. The GO‑HCur group exhibited significantly increased learning and memory performance in a Morris water maze and in reacting to a spontaneous tendency novel object test. The rats also exhibited decreased levels of lipid peroxidation, increased superoxide dismutase levels, glutathione peroxidase levels, catalase activity, and enhanced c‑Fos expression both in the hippocampus and prefrontal cortex. The results indicated that GOSD 10 mg/kg plus CURSD 50 mg/kg was able to enhance learning and memory performance in the middle‑aged rats.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL and Bohr VA: Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol. 15:565–581. 2019.PubMed/NCBI View Article : Google Scholar

2 

Yankner BA, Lu T and Loerch P: The aging brain. Annu Rev Pathol. 3:41–66. 2008.PubMed/NCBI View Article : Google Scholar

3 

Gómez-Gonzalo M, Martin-Fernandez M, Martínez-Murillo R, Mederos S, Hernández-Vivanco A, Jamison S, Fernandez AP, Serrano J, Calero P, Futch HS, et al: Neuron-astrocyte signaling is preserved in the aging brain. Glia. 65:569–580. 2017.PubMed/NCBI View Article : Google Scholar

4 

Chandran R, Kumar M, Kesavan L, Jacob RS, Gunasekaran S, Lakshmi S, Sadasivan C and Omkumar RV: Cellular calcium signaling in the aging brain. J Chem Neuroanat. 95:95–114. 2019.PubMed/NCBI View Article : Google Scholar

5 

Monti DM, Rigano MM, Monti SM and Peixoto HS: Role of antioxidants in the protection from aging-related diseases. Oxid Med Cell Longev. 2019(7450693)2019.PubMed/NCBI View Article : Google Scholar

6 

Nikhra V: The aging brain: Recent research and concepts. Gerontol Geriatr Stud. 1:1–11. 2017.

7 

Vaiserman A, Koliada A, Zayachkivska A and Lushchak O: Curcumin: A therapeutic potential in ageing-related disorders. PharmaNutrition. 14(100226)2020.

8 

Benameur T, Soleti R, Panaro MA, La Torre ME, Monda V, Messina G and Porro C: Curcumin as prospective anti-aging natural compound: Focus on brain. Molecules. 26(4794)2021.PubMed/NCBI View Article : Google Scholar

9 

Samarghandian S, Azimi-Nezhad M, Farkhondeh T and Samini F: Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomed Pharmacother. 87:223–229. 2017.PubMed/NCBI View Article : Google Scholar

10 

Suryanarayana P, Satyanarayana A, Balakrishna N, Kumar PU and Reddy GB: Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med Sci Monit. 13:BR286–BR292. 2007.PubMed/NCBI

11 

Rungratanawanich W, Abate G, Serafini MM, Guarienti M, Catanzaro M, Marziano M, Memo M, Lanni C and Uberti D: Characterization of the antioxidant effects of γ-oryzanol: Involvement of the Nrf2 pathway. Oxid Med Cell Longev: Mar 14, 2018 (Epub ahead of print).

12 

Wang YX, Li Y, Sun AM, Wang FJ and Yu GP: Hypolipidemic and antioxidative effects of aqueous enzymatic extract from rice bran in rats fed a high-fat and -cholesterol diet. Nutrients. 6:3696–3710. 2014.PubMed/NCBI View Article : Google Scholar

13 

Islam A, Rebello L and Chepyala S: Review on nanoformulations of curcumin (Curcuma longa Linn.): Special emphasis on Nanocurcumin®. Int J Nat Life Sci. 3:1–12. 2019.

14 

Hettiarachchi SS, Dunuweera SP, Dunuweera AN and Rajapakse RMG: Synthesis of curcumin nanoparticles from raw turmeric rhizome. ACS Omega. 6:8246–8252. 2021.PubMed/NCBI View Article : Google Scholar

15 

Rawal T, Mishra N, Jha A, Bhatt A, Tyagi RK, Panchal S and Butani S: Chitosan nanoparticles of gamma-oryzanol: Formulation, optimization, and in vivo evaluation of anti-hyperlipidemic activity. AAPS PharmSciTech. 19:1894–1907. 2018.PubMed/NCBI View Article : Google Scholar

16 

Rodsuwan U, Pithanthanakul U, Thisayakorn K, Uttapap D, Boonpisuttinant K, Vatanyoopaisarn S, Thumthanaruk B and Rungsardthong V: Preparation and characterization of gamma oryzanol loaded zein nanoparticles and its improved stability. Food Sci Nutr. 9:616–624. 2020.PubMed/NCBI View Article : Google Scholar

17 

Morris R: Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 11:47–60. 1984.PubMed/NCBI View Article : Google Scholar

18 

Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM and Paul SM: Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci. 5:452–457. 2002.PubMed/NCBI View Article : Google Scholar

19 

Liu J, Edamatsu R, Kabuto H and Mori A: Antioxidant action of guilingji in the brain of rats with FeCl3-induced epilepsy. Free Radic Biol Med. 9:451–454. 1990.PubMed/NCBI View Article : Google Scholar

20 

Marklund S and Marklund G: Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 47:469–474. 1974.PubMed/NCBI View Article : Google Scholar

21 

Beers RF Jr and Sizer IW: A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 195:133–140. 1952.PubMed/NCBI

22 

Hamezah HS, Durani LW, Ibrahim NF, Yanagisawa D, Kato T, Shiino A, Tanaka S, Damanhuri HA, Ngah WZW and Tooyama I: Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions. Exp Gerontol. 99:69–79. 2017.PubMed/NCBI View Article : Google Scholar

23 

Garg G, Singh S, Singh AK and Rizvi SI: N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Can J Physiol Pharmacol. 96:1189–1196. 2018.PubMed/NCBI View Article : Google Scholar

24 

Khairy EY and Attia MM: Protective effects of vitamin D on neurophysiologic alterations in brain aging: Role of brain-derived neurotrophic factor (BDNF). Nutr Neurosci. 24:650–659. 2021.PubMed/NCBI View Article : Google Scholar

25 

Pyo IS, Yun S, Yoon YE, Choi JW and Lee SJ: Mechanisms of aging and the preventive effects of resveratrol on age-related diseases. Molecules. 25(4649)2020.PubMed/NCBI View Article : Google Scholar

26 

Fischer R and Maier O: Interrelation of oxidative stress and inflammation in neurodegenerative disease: Role of TNF. Oxid Med Cell Longev. 2015(610813)2015.PubMed/NCBI View Article : Google Scholar

27 

Anyanwu EC: Neurochemical changes in the aging process: Implications in medication in the elderly. ScientificWorldJournal. 7:1603–1610. 2007.PubMed/NCBI View Article : Google Scholar

28 

Huang TT, Leu D and Zou Y: Oxidative stress and redox regulation on hippocampal-dependent cognitive functions. Arch Biochem Biophys. 576:2–7. 2015.PubMed/NCBI View Article : Google Scholar

29 

Tönnies E and Trushina E: Oxidative stress, synaptic dysfunction, and Alzheimer's disease. J Alzheimers Dis. 57:1105–1121. 2017.PubMed/NCBI View Article : Google Scholar

30 

Mastinu A, Bonini SA, Rungratanawanich W, Aria F, Marziano M, Maccarinelli G, Abate G, Premoli M, Memo M and Uberti D: Gamma-oryzanol prevents LPS-induced brain inflammation and cognitive impairment in adult mice. Nutrients. 11(728)2019.PubMed/NCBI View Article : Google Scholar

31 

Zhang X, Xing H, Zhao Y and Ma Z: Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs. Pharmaceutics. 10(74)2018.PubMed/NCBI View Article : Google Scholar

32 

Jara MO, Warnken ZN and Williams RO III: Amorphous solid dispersions and the contribution of nanoparticles to in vitro dissolution and in vivo testing: Niclosamide as a case study. Pharmaceutics. 13(97)2021.PubMed/NCBI View Article : Google Scholar

33 

Oliveira VDS, de Almeida AS, Albuquerque IDS, Duarte FÍC, Queiroz BCSH, Converti A and Lima ÁAND: Therapeutic applications of solid dispersions for drugs and new molecules: In vitro and in vivo activities. Pharmaceutics. 12(933)2020.PubMed/NCBI View Article : Google Scholar

34 

Rungratanawanich W, Cenini G, Mastinu A, Sylvester M, Wilkening A, Abate G, Bonini SA, Aria F, Marziano M, Maccarinelli G, et al: γ-Oryzanol improves cognitive function and modulates hippocampal proteome in mice. Nutrients. 11(753)2019.PubMed/NCBI View Article : Google Scholar

35 

Birben E, Sahiner UM, Sackesen C, Erzurum S and Kalayci O: Oxidative stress and antioxidant defense. World Allergy Organ J. 5:9–19. 2012.PubMed/NCBI View Article : Google Scholar

36 

Cui X, Song H and Su J: Curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through induction of nuclear factor erythroid-2-related factor 2 and heme oxygenase-1. Exp Ther Med. 14:1512–1518. 2017.PubMed/NCBI View Article : Google Scholar

37 

Massaad CA and Klann E: Reactive oxygen species in the regulation of synaptic plasticity and memory. Antioxid Redox Signal. 14:2013–2054. 2011.PubMed/NCBI View Article : Google Scholar

38 

Gallo FT, Katche C, Morici JF, Medina JH and Weisstaub NV: Immediate early genes, memory and psychiatric disorders: Focus on c-Fos, Egr1 and Arc. Front Behav Neurosci. 12(79)2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Phothi T, Tunsophon S, Tiyaboonchai W and Khongsombat O: Effects of curcumin and γ‑oryzanol solid dispersion on the brain of middle‑aged rats. Biomed Rep 17: 59, 2022.
APA
Phothi, T., Tunsophon, S., Tiyaboonchai, W., & Khongsombat, O. (2022). Effects of curcumin and γ‑oryzanol solid dispersion on the brain of middle‑aged rats. Biomedical Reports, 17, 59. https://doi.org/10.3892/br.2022.1542
MLA
Phothi, T., Tunsophon, S., Tiyaboonchai, W., Khongsombat, O."Effects of curcumin and γ‑oryzanol solid dispersion on the brain of middle‑aged rats". Biomedical Reports 17.1 (2022): 59.
Chicago
Phothi, T., Tunsophon, S., Tiyaboonchai, W., Khongsombat, O."Effects of curcumin and γ‑oryzanol solid dispersion on the brain of middle‑aged rats". Biomedical Reports 17, no. 1 (2022): 59. https://doi.org/10.3892/br.2022.1542
Copy and paste a formatted citation
x
Spandidos Publications style
Phothi T, Tunsophon S, Tiyaboonchai W and Khongsombat O: Effects of curcumin and γ‑oryzanol solid dispersion on the brain of middle‑aged rats. Biomed Rep 17: 59, 2022.
APA
Phothi, T., Tunsophon, S., Tiyaboonchai, W., & Khongsombat, O. (2022). Effects of curcumin and γ‑oryzanol solid dispersion on the brain of middle‑aged rats. Biomedical Reports, 17, 59. https://doi.org/10.3892/br.2022.1542
MLA
Phothi, T., Tunsophon, S., Tiyaboonchai, W., Khongsombat, O."Effects of curcumin and γ‑oryzanol solid dispersion on the brain of middle‑aged rats". Biomedical Reports 17.1 (2022): 59.
Chicago
Phothi, T., Tunsophon, S., Tiyaboonchai, W., Khongsombat, O."Effects of curcumin and γ‑oryzanol solid dispersion on the brain of middle‑aged rats". Biomedical Reports 17, no. 1 (2022): 59. https://doi.org/10.3892/br.2022.1542
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team